Nutritional Neuroscience,
Год журнала:
2023,
Номер
27(8), С. 870 - 886
Опубликована: Сен. 20, 2023
ABSTRACTParkinson's
disease
(PD)
is
a
chronic
neurodegenerative
(NDD)
due
to
the
degeneration
of
dopaminergic
neurons
(DNs)
in
substantia
nigra
(SN).
PD
characterized
by
diverse
motor
symptoms
such
as
rigidity,
resting
tremors,
and
bradykinesia,
non-motor
cognitive
dysfunction
sleep
disturbances.
Vitamin
D
(VD),
VD
receptor
(VDR),
metabolites
are
present
brain
play
role
maintaining
development,
differentiation,
functions
DNs.
VDRs
exert
protective
effects
against
neuropathology
modulating
functional
capacity
DNs
neurotransmission
SN.
In
virtue
its
anti-inflammatory
antioxidant
activities,
could
be
effective
prevention
treatment
PD.
exerts
neuroprotective
effect
reducing
oxidative
stress
mitochondrial
dysfunction,
increasing
autophagy
brain-derived
neurotrophic
factor
(BDNF).
Low
serum
level
connected
with
development
dementia
The
VD-mediated
augmenting
interrelated
safeguarding
synaptic
plasticity
modulation
neurotransmitter
release.
deficiency
linked
severity
olfactory
which
precedes
progression
symptomatic
However,
precise
remains
unidentified,
there
conflict
about
whether
can
ameliorate
or
not.KEYWORDS:
Parkinson's
diseaseVitamin
DVD
receptorBDNFsubstantia
nigraAutophagyOxidative
stressdopaminergic
AcknowledgementsNot
applicable.Authors'
contributionsAAH
conceptualized
manuscript,
wrote,
edited,
reviewed
main
text
approved
final
edition
manuscript.Disclosure
statementNo
potential
interest
was
reported
author(s).Additional
informationFundingThe
author(s)
no
funding
associated
work
featured
this
article.
Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(10)
Опубликована: Май 1, 2024
Parkinson's
disease
(PD)
is
a
neurodegenerative
disorder
of
the
brain
and
manifested
by
motor
non-motor
symptoms
because
degenerative
changes
in
dopaminergic
neurons
substantia
nigra.
PD
neuropathology
associated
with
mitochondrial
dysfunction,
oxidative
damage
apoptosis.
Thus,
modulation
apoptosis
growth
factors
could
be
novel
boulevard
management
PD.
Brain-derived
neurotrophic
factor
(BDNF)
its
receptor
tropomyosin
kinase
type
B
(TrkB)
are
chiefly
involved
neuropathology.
BDNF
promotes
survival
nigra
enhances
functional
activity
striatal
neurons.
Deficiency
TrkB
triggers
degeneration
accumulation
α-Syn
As
well,
BDNF/TrkB
signalling
reduced
early
phase
Targeting
specific
activators
may
attenuate
this
review
aimed
to
discuss
potential
role
against
In
conclusion,
decreased
linked
severity
long-term
complications.
Activation
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Март 27, 2024
Abstract
Parkinson's
disease
(PD)
is
a
progressive
neurodegenerative
as
result
of
the
degeneration
dopaminergic
neurons
in
substantia
nigra
pars
compacta
(SNpc).
The
fundamental
features
PD
are
motor
and
non-motor
symptoms.
symptoms
develop
due
to
disruption
neurotransmitters
other
such
γ-aminobutyric
acid
(GABA).
potential
role
GABA
neuropathology
concerning
was
not
precisely
discussed.
Therefore,
this
review
intended
illustrate
possible
regarding
pathway
essential
regulating
inhibitory
tone
prevent
excessive
stimulation
cerebral
cortex.
Degeneration
linked
with
reducing
GABAergic
neurotransmission.
Decreasing
activity
promotes
mitochondrial
dysfunction
oxidative
stress,
which
highly
related
neuropathology.
Hence,
restoring
by
agonists
may
attenuate
progression
dysregulation
SNpc
contributes
developing
Besides,
also
pathway,
amelioration
reduce
In
conclusion,
deregulation
might
be
intricate
Improving
novel,
beneficial
approach
control
CNS Neuroscience & Therapeutics,
Год журнала:
2023,
Номер
30(4)
Опубликована: Ноя. 12, 2023
Abstract
Depression
is
a
mood
disorder
characterized
by
abnormal
thoughts.
The
pathophysiology
of
depression
related
to
the
deficiency
serotonin
(5HT),
which
derived
from
tryptophan
(Trp).
Mitochondrial
dysfunction,
oxidative
stress,
and
neuroinflammation
are
involved
in
pathogenesis
depression.
Notably,
renin–angiotensin
system
(RAS)
depression,
different
findings
revealed
that
angiotensin‐converting
enzyme
inhibitors
(ACEIs)
angiotensin
receptor
blockers
(ARBs)
may
be
effective
However,
underlying
mechanism
for
role
dysregulated
brain
RAS‐induced
remains
speculative.
Therefore,
this
review
aimed
revise
conceivable
ACEIs
ARBs
how
these
agents
ameliorate
Dysregulation
RAS
triggers
development
progression
through
reduction
5HT
expression
brain‐derived
neurotrophic
factor
(BDNF)
induction
mitochondrial
neuroinflammation.
inhibition
central
classical
ARBS
activation
non‐classical
prevent
regulating
5HT,
BDNF,
Neuropsychopharmacology Reports,
Год журнала:
2024,
Номер
44(3), С. 639 - 649
Опубликована: Июль 29, 2024
Abstract
Neurodegenerative
diseases
(NDs)
such
as
Alzheimer
disease
(AD)
and
Parkinson
(PD)
are
group
of
affecting
the
central
nervous
system
(CNS)
characterized
by
progressive
neurodegenerations
cognitive
impairment.
Findings
from
different
studies
highlighted
beneficial
detrimental
effects
serum
uric
acid
on
development
progression
NDs.
Therefore,
this
mini‐review
aims
to
discuss
The
neuroprotective
effect
is
mainly
related
antioxidant
which
alleviates
oxidative
stress‐induced
neurodegeneration
in
AD
PD.
However,
long‐term
hyperuricemia
prompts
for
Hyperuricemia
associated
with
impairment
dementia,
gout
increases
dementia
risk.
In
addition,
can
cause
cerebral
vascular
injury
a
risk
factor
Taken
together,
relationship
between
NDs
remains
conflicting.
Hence,
preclinical
clinical
indicated
regard.
Journal of Neural Transmission,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 11, 2024
Abstract
Parkinson’s
disease
(PD)
has
been
linked
to
a
vast
array
of
vitamins
among
which
vitamin
B12
(Vit
B12)
is
the
most
relevant
and
often
investigated
specially
in
context
intrajejunal
levodopa
infusion
therapy.
Vit
deficiency,
itself,
reported
cause
acute
parkinsonism.
Nevertheless,
concrete
mechanisms
through
deficiency
interacts
with
PD
terms
pathophysiology,
clinical
manifestation
progression
remains
unclear.
Recent
studies
have
suggested
that
along
induced
hyperhomocysteinemia
are
correlated
specific
phenotypes
characterized
early
postural
instability
falls
more
rapid
motor
progression,
cognitive
impairment,
visual
hallucinations
autonomic
dysfunction.
Specific
features
such
as
polyneuropathy
also
specifically
In
this
review,
we
explore
link
between
physiopathology
regarding
dysfunctional
neural
pathways,
neuropathological
processes
well
reviewing
major
traits
Levodopa-mediated
neuropathy.
Finally,
provide
an
overview
therapeutic
effect
supplementation
posit
practical
guideline
for
testing
supplementation.
Journal of Biomedical and Sustainable Healthcare Applications,
Год журнала:
2024,
Номер
unknown, С. 10 - 21
Опубликована: Янв. 5, 2024
The
functionality
of
an
individual's
brain
is
influenced
by
the
interaction
between
various
environmental
factors,
including
diet,
and
genetic
predispositions.
objective
diet
in
maintaining
optimal
function
may
significantly
contribute
to
treatment
prevention
mental
health
illness.
Experimental
models
epidemiological
studies
have
provided
evidence
demonstrating
that
both
collective
specific
constituents
human
exert
influence
on
function.
This
narrative
review
examines
five
primary
dimensions
impact
performance.
topics
interest
include:
(1)
development
brain;
(2)
networks
neurotransmitters
involved
signaling;
(3)
memory
cognitive
processes;
(4)
symmetry
protein
synthesis
breakdown;
(5)
detrimental
consequences
resulting
from
persistent
inflammatory
processes.
