Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 8, 2024
The
death
of
cells
can
occur
through
various
pathways,
including
apoptosis,
necroptosis,
mitophagy,
pyroptosis,
endoplasmic
reticulum
stress,
oxidative
ferroptosis,
cuproptosis,
and
disulfide-driven
necrosis.
Increasing
evidence
suggests
that
mitophagy
ferroptosis
play
crucial
regulatory
roles
in
the
development
stroke.
In
recent
years,
incidence
stroke
has
been
gradually
increasing,
posing
a
significant
threat
to
human
health.
Hemorrhagic
accounts
for
only
15%
all
strokes,
while
ischemic
is
predominant
type,
representing
85%
cases.
Ischemic
refers
clinical
syndrome
characterized
by
local
ischemic-hypoxic
necrosis
brain
tissue
due
cerebrovascular
disorders,
leading
rapid
onset
corresponding
neurological
deficits.
Currently,
specific
therapeutic
approaches
targeting
pathophysiological
mechanisms
injury
mainly
include
intravenous
thrombolysis
endovascular
intervention.
Despite
some
efficacy,
these
inevitably
lead
ischemia-reperfusion
injury.
Therefore,
exploration
treatment
options
remains
challenging
task.
light
this
background,
advancements
targeted
therapy
diseases
offer
new
direction
such
diseases.
review,
we
summarize
progress
regulating
emphasize
their
potential
molecular
pathogenesis.
Importantly,
systematically
elucidate
role
medicinal
plants
active
metabolites
stroke,
providing
insights
perspectives
drugs
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 26, 2025
Background
Ferroptosis
is
a
newly
identified
type
of
iron-dependent
cell
death
that
characterized
by
an
increase
in
intracellular
iron
ions,
which
disrupt
the
balance
cellular
lipid
peroxidation
system,
causing
and
ultimately
resulting
death.
Interestingly,
ferroptosis
modulated
hypoxia
plays
role
hypoxia-related
diseases.
Therefore,
we
performed
bibliometric
review
Web
Science
Core
Collection
(WoSCC)
database
to
investigate
link
between
from
January
2013
December
2023.
Method
The
core
collection
within
bibliographic
index
was
consulted
extract
relevant
articles
reviews.
Data
on
publications,
countries,
institutions,
authors,
journals,
citations,
keywords
included
studies
were
systematically
analyzed
using
Microsoft
Excel
2019
CiteSpace
6.3.R1
software.
Result
A
comprehensive
analysis
visualization
472
research
papers
under
hypoxic
conditions
published
2023
revealed
emerging
hotspots
trends.
Initially,
scarcity
existed
this
field.
However,
succeeded
significant
interest
subsequent
years,
culminating
peak
204
publications
Research
field
focused
primarily
Asian
region.
Notably,
include
diseases
related
hypoxia,
treatment
therapy
pathogenesis.
Among
researchers
field,
Supuran
emerged
as
most
prolific
author.
Wuhan
University
leading
institution
terms
output,
China
country
area
study.
top
ten
journals
ranked
number
nine
classified
Q1,
indicating
high
level
credibility
these
studies.
conducted
Stockwell
et
al.,
featured
journal
“
Cell
,”
currently
has
citations.
Present
scholarly
pursuits
are
comprehending
mechanisms
through
interventions
affect
pathway,
well
probing
pinpointing
prospective
targets.
Conclusion
This
study
highlights
key
areas
trends
presence
conditions,
thus
providing
valuable
insights
for
future
directions
exploration
diagnosis
PLoS ONE,
Год журнала:
2025,
Номер
20(4), С. e0321751 - e0321751
Опубликована: Апрель 16, 2025
Objective
The
aim
of
this
study
is
to
use
network
pharmacology
and
data
mining
explore
the
role
traditional
Chinese
medicine
(TCM)
in
ischemic
stroke
(IS)
intervention
by
ferroptosis
regulation.
results
will
provide
reference
for
related
research
on
IS.
Methods
ferroptosis-related
targets
were
obtained
from
GeneCards,
GeneCLiP3,
FerrDdb
databases,
while
IS
sourced
GeneCards
DisGeNET
databases.
Venny
was
used
identify
associated
with
ferroptosis.
A
protein-protein
interaction
(PPI)
analysis
then
conducted,
machine
learning
screening
validate
these
potential
targets.
that
met
specific
criteria
their
compounds
allowed
us
select
TCMs.
mechanistic
conducted
using
DAVID
database.
PPI
diagrams,
target-compound
target-compound-TCM
diagrams
constructed.
Finally,
molecular
docking
technology
verify
binding
activities
TCM
core
components
identified
In
addition,
properties,
flavors,
meridian
tropism,
therapeutic
effects
candidate
TCMs
analyzed
statistically
evaluated.
Results
total
706
obtained,
14
learning.
Furthermore,
413
301
screened,
prescriptions
stable.
primarily
exhibited
cold,
warm,
bitter
taste,
pungent
liver
meridian,
heat-cleaning
medicinal,
tonify
deficiency
properties.
Conclusions
This
investigated
regulation
TCM.
We
began
investigating
ferroptosis,
we
also
relevant
mechanism
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 8, 2024
The
death
of
cells
can
occur
through
various
pathways,
including
apoptosis,
necroptosis,
mitophagy,
pyroptosis,
endoplasmic
reticulum
stress,
oxidative
ferroptosis,
cuproptosis,
and
disulfide-driven
necrosis.
Increasing
evidence
suggests
that
mitophagy
ferroptosis
play
crucial
regulatory
roles
in
the
development
stroke.
In
recent
years,
incidence
stroke
has
been
gradually
increasing,
posing
a
significant
threat
to
human
health.
Hemorrhagic
accounts
for
only
15%
all
strokes,
while
ischemic
is
predominant
type,
representing
85%
cases.
Ischemic
refers
clinical
syndrome
characterized
by
local
ischemic-hypoxic
necrosis
brain
tissue
due
cerebrovascular
disorders,
leading
rapid
onset
corresponding
neurological
deficits.
Currently,
specific
therapeutic
approaches
targeting
pathophysiological
mechanisms
injury
mainly
include
intravenous
thrombolysis
endovascular
intervention.
Despite
some
efficacy,
these
inevitably
lead
ischemia-reperfusion
injury.
Therefore,
exploration
treatment
options
remains
challenging
task.
light
this
background,
advancements
targeted
therapy
diseases
offer
new
direction
such
diseases.
review,
we
summarize
progress
regulating
emphasize
their
potential
molecular
pathogenesis.
Importantly,
systematically
elucidate
role
medicinal
plants
active
metabolites
stroke,
providing
insights
perspectives
drugs
