Expert Opinion on Therapeutic Targets,
Год журнала:
2024,
Номер
unknown, С. 1 - 27
Опубликована: Дек. 23, 2024
Introduction
Ischemic
stroke
(IS),
a
major
cause
of
mortality
and
disability
worldwide,
remains
significant
healthcare
challenge
due
to
limited
therapeutic
options.
Ferroptosis,
distinct
iron-dependent
form
regulated
cell
death
characterized
by
lipid
peroxidation
oxidative
stress,
has
emerged
as
crucial
mechanism
in
IS
pathophysiology.
This
review
explores
the
role
ferroptosis
its
potential
for
driving
innovative
strategies.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 8, 2024
Stroke
ranks
as
the
second
most
significant
contributor
to
mortality
worldwide
and
is
a
major
factor
in
disability.
Ischemic
strokes
account
for
71%
of
all
stroke
incidences
globally.
The
foremost
approach
treating
ischemic
prioritizes
quick
reperfusion,
involving
methods
such
intravenous
thrombolysis
endovascular
thrombectomy.
These
techniques
can
reduce
disability
but
necessitate
immediate
intervention.
After
cerebral
ischemia,
inflammation
rapidly
arises
vascular
system,
producing
pro-inflammatory
signals
that
activate
immune
cells,
which
turn
worsen
neuronal
injury.
Following
an
overload
intracellular
iron
triggers
Fenton
reaction,
resulting
excess
free
radicals
cause
lipid
peroxidation
damage
cellular
membranes,
ultimately
leading
ferroptosis.
relationship
between
ferroptosis
increasingly
recognized
vital
process
ischemia-reperfusion
(I/R).
Inflammatory
processes
disturb
balance
encourage
(LPO)
through
neuroglial
while
also
reducing
activity
antioxidant
systems,
contributing
Furthermore,
products
generated
during
ferroptosis,
along
with
damage-associated
molecular
patterns
(DAMPs)
released
from
ruptured
cell
incite
inflammation.
Given
complex
inflammation,
investigating
their
interaction
brain
I/R
crucial
understanding
disease
development
creating
innovative
therapeutic
options.
Consequently,
this
article
will
provide
comprehensive
introduction
mechanisms
linking
neuroinflammation,
well
evaluate
potential
treatment
modalities,
goal
presenting
various
insights
alleviating
injury
exploring
new
avenues.
Journal of Integrative Neuroscience,
Год журнала:
2024,
Номер
23(7)
Опубликована: Июль 23, 2024
Background:
Small
artery
occlusion
(SAO)
is
a
common
ischemic
stroke
subtype.
However,
its
clinical
outcome
can
be
more
severe
than
commonly
understood.
The
severity
of
SAO
vary,
ranging
from
mild
to
moderate.
Iron
deposition
has
been
associated
with
the
development
and
progression
stroke.
specific
distribution
relationship
in
remain
unclear.
study’s
purpose
investigate
differences
iron
between
(SAO-MiS)
moderate
(SAO-MoS)
through
quantitative
susceptibility
mapping
(QSM)
association
neurological
deficits.
Methods:
Sixty-eight
participants
within
24
hours
first
onset
were
enrolled
separated
into
SAO-MiS
SAO-MoS
according
National
Institutes
Health
Stroke
Scale
(NIHSS)
scores.
QSM
helped
calculate
maps,
reflecting
content
brain.
maps
analyzed
using
voxel-wise
statistical
analysis
compare
SAO-MoS.
Then,
differentially
distributed
differentiate
support
vector
machine
(SVM)
methods.
Results:
Compared
SAO-MiS,
depicted
elevated
left
pallidum,
parahippocampal
gyrus,
superior
frontal
gyrus
medial
region,
lower
right
superior/middle
bilateral
supplementary
motor
area.
Based
on
deposition,
SVM
classifier’s
revealed
high
power
discriminate
SAO-MiS.
In
addition,
fibrinogen,
triglyceride
(TG),
total
cholesterol
(TC)
linked
values
brain
regions.
Conclusions:
Our
study
after
differently
results
indicate
that
could
play
role
pathophysiology
correlation
severity.
Reviews in the Neurosciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Abstract
Stroke
is
a
severe
neurological
disease
and
major
worldwide
issue,
mostly
manifesting
as
ischemic
stroke
(IS).
In
order
to
create
effective
treatments
for
IS,
it
imperative
fully
understand
the
underlying
pathologies,
existing
therapeutic
choices
are
inadequate.
Recent
investigations
have
shown
complex
relationships
between
several
programmed
cell
death
(PCD)
pathways,
including
necroptosis,
ferroptosis,
pyroptosis,
their
correlation
with
immune
responses
during
IS.
However,
this
relationship
still
unclear.
To
address
gap,
review
study
explored
cellular
interactions
in
microenvironment
of
Then,
validate
prior
findings
uncover
biomarkers,
investigated
bioinformatics
studies.
Several
nuclear
factor
kappa-light-chain-enhancer
activated
B
cells
(NF-κB),
Toll-like
receptor
4
(TLR4),
receptor-interacting
protein
kinase
(RIPK),
were
involved
PCD-immune
interactions.
The
studies
reported
key
biomarkers
such
glutathione
peroxidase
(GPX4),
NOD-like
family
pyrin
domain
containing
3
(NLRP3),
gasdermin
D
(GSDMD),
TLR4,
which
important
implications
cuproptosis,
necroptosis
respectively.
These
associated
PCD
mechanisms
oxidative
stress
inflammatory
reactions.
infiltration
analysis
consistently
revealed
significant
pathways
detrimental
cells,
neutrophils
γδ
T
cells.
Conversely,
M2
macrophages
helper
showed
protective
effects.
conclusion,
considering
intricate
network
emphasized
necessity
paradigm
shift
approaches
injuries
that
related
network.
Expert Opinion on Therapeutic Targets,
Год журнала:
2024,
Номер
unknown, С. 1 - 27
Опубликована: Дек. 23, 2024
Introduction
Ischemic
stroke
(IS),
a
major
cause
of
mortality
and
disability
worldwide,
remains
significant
healthcare
challenge
due
to
limited
therapeutic
options.
Ferroptosis,
distinct
iron-dependent
form
regulated
cell
death
characterized
by
lipid
peroxidation
oxidative
stress,
has
emerged
as
crucial
mechanism
in
IS
pathophysiology.
This
review
explores
the
role
ferroptosis
its
potential
for
driving
innovative
strategies.
