Glial Perturbation in Metal Neurotoxicity: Implications for Brain Disorders

Neuroglia, Год журнала: 2025, Номер 6(1), С. 4 - 4

Опубликована: Янв. 6, 2025

Overexposure of humans to heavy metals and essential poses a significant risk for the development neurological neurodevelopmental disorders. The mechanisms through which these exert their effects include generation reactive oxygen species, mitochondrial dysfunction, activation inflammatory pathways, disruption cellular signaling. function glial cells in brain maintenance homeostasis cannot be overlooked. are particularly susceptible metal-induced neurotoxicity. Accumulation promotes microglial activation, triggering responses that can coincide with other neurotoxicity, inducing alteration synaptic transmission, cognitive deficit, neuronal damage. In this review, we highlighted role dysfunction some selected neurodegenerative diseases We further dive into how exposure such as nickel, manganese, methyl mercury, cadmium, iron, arsenic, lead affect functions microglia, astrocytes, oligodendrocytes they on relation Potential therapeutic interventions use new improved chelating agents antioxidant therapies might approach alleviating perturbations.

Язык: Английский

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Decoding the Role of Kinesin Superfamily Proteins in Glioma Progression

Journal of Molecular Neuroscience, Год журнала: 2025, Номер 75(1)

Опубликована: Янв. 23, 2025

Язык: Английский

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Cancer-associated fibroblasts in hepatocellular carcinoma: heterogeneity, mechanisms and therapeutic targets

Hepatology International, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

Язык: Английский

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Immunological challenges and opportunities in glioblastoma multiforme: A comprehensive view from immune system lens

Life Sciences, Год журнала: 2024, Номер 357, С. 123089 - 123089

Опубликована: Окт. 1, 2024

Язык: Английский

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