Recent developments in the chemistry and enzyme inhibitory activity of fused thiazoles and thiadiazoles

Vietnam Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Abstract The combination of cyclization reactions thiadiazoles and benzothiazoles with Pd‐catalyzed cross‐coupling provided a convenient synthesis annulated, fluorinated non‐fluorinated heterocycles, such as 1,3,4‐thiadiazolo[3,2‐ ]pyrimidin‐5‐ones, benzothiazolo[3,2‐ ]pyridimidin‐4‐ones, benzothiazolo[2,3‐ b ]quinazolin‐12‐ones thiadiazolo[2′,3′:2,3]‐imidazo[4,5‐ ]indoles. inhibitory activity the products against nucleotide pyrophosphatases (NPPs), alkaline phosphatases (APs), ectonucleoside triphosphate diphosphohydrolases (NTPDs), cervical cancer cells (HeLa), monoamine oxidases (MAO) was studied experimentally further elucidated by docking studies. As result, several heterocycles were identified privileged core structures, compounds each series lead structures for investigations.

Язык: Английский

Recent advances in the synthesis of thiazolo[4,5-b]pyridines. Part 3. Focus on biological activity (microreview)

Chemistry of Heterocyclic Compounds, Год журнала: 2025, Номер unknown

Опубликована: Июнь 3, 2025

Язык: Английский

Recent advances in the synthesis of thiazolo[4,5-b]pyridines. Part 2: Focus on thiazole annulation to pyridine ring (microreview)

Chemistry of Heterocyclic Compounds, Год журнала: 2024, Номер 60(3-4), С. 130 - 132

Опубликована: Апрель 1, 2024

Язык: Английский