Polymers,
Год журнала:
2023,
Номер
15(8), С. 1937 - 1937
Опубликована: Апрель 19, 2023
Polyhydroxyalkanoates
(PHA)
are
biodegradable
plastic.
Numerous
bacteria
produce
PHAs
under
environmental
stress
conditions,
such
as
excess
carbon-rich
organic
matter
and
limitations
of
other
nutritional
elements
potassium,
magnesium,
oxygen,
phosphorus,
nitrogen.
In
addition
to
having
physicochemical
properties
similar
fossil-fuel-based
plastics,
have
unique
features
that
make
them
ideal
for
medical
devices,
easy
sterilization
without
damaging
the
material
itself
dissolution
following
use.
can
replace
traditional
plastic
materials
used
in
biomedical
sector.
be
a
variety
applications,
including
implants,
drug
delivery
wound
dressings,
artificial
ligaments
tendons,
bone
grafts.
Unlike
not
manufactured
from
petroleum
products
or
fossil
fuels
are,
therefore,
environment-friendly.
this
review,
recent
overview
applications
with
special
emphasis
on
sectors,
delivery,
healing,
tissue
engineering,
biocontrols,
discussed.
Bioactive Materials,
Год журнала:
2020,
Номер
6(2), С. 346 - 360
Опубликована: Авг. 29, 2020
Research
and
development
of
the
ideal
artificial
bone-substitute
materials
to
replace
autologous
allogeneic
bones
for
repairing
bone
defects
is
still
a
challenge
in
clinical
orthopedics.
Recently,
poly(lactic-co-glycolic
acid)
(PLGA)-based
are
attracting
increasing
attention
as
benefit
their
suitable
biocompatibility,
degradability,
mechanical
properties,
capabilities
promote
regeneration.
In
this
article,
we
comprehensively
review
made
from
PLGA
or
composites
other
organic
inorganic
substances,
elaborate
on
applications
regeneration
with
without
bioactive
factors,
prospect
challenges
opportunities
Abstract
Synthetic
polymeric
scaffolds
are
commonly
used
in
bone
tissue
engineering
(BTE)
due
to
their
biocompatibility
and
adequate
mechanical
properties.
However,
hydrophobicity
the
lack
of
specific
cell
recognition
sites
confined
practical
application.
In
this
study,
improve
seeding
efficiency
osteoinductivity,
an
injectable
thermo-sensitive
chitosan
hydrogel
(CSG)
was
incorporated
into
a
3D-printed
poly(ε-caprolactone)
(PCL)
scaffold
form
hybrid
scaffold.
To
demonstrate
feasibility
system
for
BTE
application,
rabbit
marrow
mesenchymal
stem
cells
(BMMSCs)
morphogenetic
protein-2
(BMP-2)
were
encapsulated
CSG.
Pure
PCL
as
controls.
Cell
proliferation
viability
investigated.
Osteogenic
gene
expressions
BMMSCs
various
determined
with
reverse
transcription
polymerase
chain
reaction
(RT-PCR).
Growth
factor
releasing
profile
tests
performed.
CCK-8
assay
confirmed
greater
retention
groups.
Confocal
microscopy
showed
even
distribution
system.
After
2-week
osteogenic
culture
vitro
,
stronger
osteogenesis
bone-matrix
formation.
conclude,
chitosan/PCL
favorable
platform
its
capacity
carry
drugs,
excellent
strength.
Polymers,
Год журнала:
2022,
Номер
14(6), С. 1153 - 1153
Опубликована: Март 14, 2022
Synthetic
biopolymers
are
effective
cues
to
replace
damaged
tissue
in
the
engineering
(TE)
field,
both
for
vitro
and
vivo
application.
Among
them,
poly-l-lactic
acid
(PLLA)
has
been
highlighted
as
a
biomaterial
with
tunable
mechanical
properties
biodegradability
that
allows
fabrication
of
porous
scaffolds
different
micro/nanostructures
via
various
approaches.
In
this
review,
we
discuss
structure
PLLA,
its
main
properties,
most
recent
advances
overcoming
hydrophobic,
synthetic
nature,
which
limits
biological
signaling
protein
absorption.
With
aim,
PLLA-based
can
be
exposed
surface
modification
or
combined
other
biomaterials,
such
natural
polymers
bioceramics.
Further,
technologies,
phase
separation,
electrospinning,
3D
printing,
scrutinized
along
applications
employed
repair
strategies.
Overall,
review
focuses
on
PLLA
TE
finally
affording
an
insight
into
future
directions
challenges
address
improvement
scaffold
properties.
