AMPK agonist AICAR ameliorates maternal hepatic lipid metabolism disorder, inflammation, and fibrosis caused by PM2.5 exposure during pregnancy
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 13, 2025
Liver
is
an
important
target
organ
of
ambient
fine
particulate
matter
(PM2.5).
Numerous
studies
have
shown
that
PM2.5
exposure
can
cause
liver
lipid
metabolism
disorders
and
other
damage
in
mammals.
However,
the
impact
on
health
during
pregnancy,
a
sensitive
life
stage,
remains
understudied,
underlying
mechanisms
are
also
unknown.
Given
critical
role
adenosine
5'-monophosphate
activated
protein
kinase
(AMPK)
regulating
inflammation,
we
hypothesize
AMPK
activation
may
mitigate
maternal
hepatic
disorders,
reduce
attenuate
fibrosis
induced
by
pregnancy.
To
test
this
hypothesis,
pregnant
C57BL/6
mice
were
randomly
assigned
to
4
groups:
filtered
air
(FA)
+
NS
(normal
saline),
PM2.5+NS,
FA
AICAR
(acadesine,
activator),
PM2.5+AICAR.
PM2.5+NS
PM2.5+AICAR
groups
continuously
exposed
with
whole-body
chamber,
while
two
chamber.
Simultaneously,
received
intraperitoneal
injections
agonist
(200
mg/kg∙bw
per
day)
from
gestational
day
13
(GD13)
GD17,
administered
normal
saline
injection.
We
found
dyslipidemia
mice,
which
was
alleviated
treatment.
Histopathological
analysis
showed
pregnancy
deposition
biochemical
assays
revealed
triglyceride
cholesterol
levels
significantly
increased
after
PM2.5,
whereas
treatment
ameliorated
Furthermore,
disrupted
expression
key
genes
proteins
associated
synthesis,
fibrosis,
mitigated
these
effects.
These
findings
demonstrated
ameliorates
reduces
attenuates
caused
be
action
for
injury
Язык: Английский
The impact of PM2.5 and its constituents on gestational diabetes mellitus: a retrospective cohort study
BMC Public Health,
Год журнала:
2024,
Номер
24(1)
Опубликована: Авг. 19, 2024
There
is
increasing
evidence
that
exposure
to
PM
Язык: Английский
Non-optimum Temperatures Modified the Associations between PM2.5 and its Components and Hospitalizations for Chronic Kidney Disease in China
Global Transitions,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Does Nonsteroidal Anti-inflammatory Drug Use Modify All-Cause and Cause-Specific Mortality Associated with PM2.5 and Its Components? A Nationally Representative Cohort Study (2007–2017)
Environment & Health,
Год журнала:
2024,
Номер
3(1), С. 14 - 25
Опубликована: Окт. 22, 2024
Several
studies
reported
that
nonsteroidal
anti-inflammatory
drug
(NSAID)
use
could
alleviate
subclinical
effects
of
short-term
exposure
to
fine
particulate
matter
(PM2.5).
However,
whether
chronic
NSAID
mitigate
the
long-term
PM2.5
and
its
components
on
population
mortality
has
been
unknown.
Based
a
national
representative
survey
47,086
adults
(2007-2010)
with
follow-up
information
primary
cause
death
(until
2017),
we
investigated
associations
major
components,
including
black
carbon
(BC),
ammonium
(NH4
+),
nitrate
(NO3
-),
organic
(OM),
sulfate
(SO4
2-),
all-cause
cause-specific
using
Cox
proportional
hazards
model.
We
also
evaluated
effect
modification
by
(including
broad
NSAIDs,
aspirin,
or
ibuprofen)
interaction
models.
Long-term
exposures
were
associated
increased
risks
mortality,
where
BC,
OM,
SO4
2-
showed
stronger
associations.
Ibuprofen
risks,
while
no
significant
modifying
aspirin
observed.
For
instance,
along
per
interquartile
range
increment
in
concentration
(34.8
μg/m3),
hazard
ratios
(HRs)
1.21
(95%
CI:
1.19,
1.22)
1.10
1.01,
1.19)
nonibuprofen
ibuprofen
groups
(P
for
=
0.026),
respectively.
Cause-specific
analyses
indicated
mainly
cardiovascular
disease
(CVD)
especially
ischemic
heart
(IHD)
attributable
components.
Stratified
found
more
apparent
mitigating
among
participants
without
diseases,
≤50
years,
female
participants,
rural
residents,
those
lower
education
levels.
Our
findings
suggested
potential
implications
reducing
caused
through
personalized
interventions.
Язык: Английский