Biogenic synthesis copper oxide nanoparticle from Artemisia judaica and their evaluation of biological and photocatalytic activities

Journal of Industrial and Engineering Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Comparative Analysis of the Inhibitory Effects of Aloin on Tyrosinase Supported by Fe3o4@Rgo: Investigation of Interaction Mechanisms, Inhibitory Activity, and Conformational Changes

Опубликована: Янв. 1, 2025

Язык: Английский

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Green Synthesis and Characterization of Zinc Oxide Nanoparticles Mediated by Nyctanthes arbor-tristis Leaf Extract: Exploring Antidiabetic, Anticancer, and Antimicrobial Activities

Journal of Cluster Science, Год журнала: 2025, Номер 36(2)

Опубликована: Фев. 20, 2025

Язык: Английский

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EVALUATION OF ETHANOLIC EXTRACT OF TILIACORA ACUMINATA LEAVES FOR PANCREATIC LIPASE INHIBITION AND LIPID MODULATION: IN SILICO AND IN VITRO STUDIES

Asian Journal of Pharmaceutical and Clinical Research, Год журнала: 2025, Номер unknown, С. 175 - 183

Опубликована: Апрель 7, 2025

Objectives: Hypercholesterolemia is a significant risk factor for cardiovascular disease and dyslipidemia. In 33–58% of individuals, current medications targeting 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) low-density lipoprotein (LDL) receptor do not intend to reduce LDL cholesterol. Pancreatic lipase, responsible cholesterol absorption, can be potential target in hypercholesterolemia. The study aims conduct virtual screening molecular dynamics compounds derived from ethanolic extract Tiliacora acuminata leaves (TAL-EE) with pancreatic evaluate cell viability 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) assay, assess lipase inhibition, perform lipid accumulation assessment (Oil Red O staining) measure triglycerides (TG) HepG2 cells. Methods: Docking was carried out using AutoDock tools, interaction analysis performed PyMOL 2.0. Para-nitrophenyl butyrate porcine were used test TAL-EE inhibition. Viability (MTT test, IC50), Oil staining, measurements total (TC) triglyceride levels conducted cells treated TAL-EE. Results: 5α-Androstan-16-one cyclic ethylene mercaptole identified through have the highest docking score (−9.4 kcaL/moL) exhibiting stability dynamic studies. IC50 assay reported 20 μg/mL. After 48 h at lower doses, exhibited 67% reduction activity increased TG TC medium cells, indicating reduced intracellular levels. Conclusion: showed inhibition modulation, suggesting as an antihypercholesterolemic agent.

Язык: Английский

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Differential immobilization of cadmium and changes in soil surface charge in acidic Ultisol by chitosan and citric acid: effect of their functional groups

Environmental Geochemistry and Health, Год журнала: 2024, Номер 46(8)

Опубликована: Июль 3, 2024

Язык: Английский

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Bionanomining: bioengineered CuO nanoparticles from mining and organic waste for photo-catalytic dye degradation

Environmental Geochemistry and Health, Год журнала: 2024, Номер 46(9)

Опубликована: Июль 16, 2024

Язык: Английский

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Synthesis of reduced graphene oxide supported FeCu and its environmental applications

Environmental Science and Pollution Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

Язык: Английский

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