Efficient strategy for alleviating neuronal apoptosis and oxidative stress damage of Alzheimer's disease through dual targeting BCL-2 gene promoter i-motif and β-amyloid

Redox Biology, Год журнала: 2025, Номер unknown, С. 103600 - 103600

Опубликована: Март 1, 2025

Язык: Английский

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Metabolic Factors Mediate the Causal Effect of Physical Activity and Sedentary Behavior on Stroke and Its Subtypes: Evidence from Mendelian Randomization Study

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Язык: Английский

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The Possible Role of Metformin and Fibroblast Growth Factor‐21 in Multiple Sclerosis Neuropathology: Birds of a Feather Flock Together

European Journal of Neuroscience, Год журнала: 2025, Номер 61(7)

Опубликована: Апрель 1, 2025

Multiple sclerosis (MS) is a progressive demyelinating disease of the CNS, characterized by inflammation, formation CNS plaques, and damage to neuronal myelin sheath (Graphical abstract). Fibroblast growth factor 21 (FGF21) involved in various metabolic disorders neurodegenerative diseases. FGF21 its co-receptor β-Kloth are essential remyelination process MS. Metformin, an insulin-sensitizing drug that first-line treatment for type 2 diabetes mellitus (T2DM), may have potential neuroprotective impact up-regulating production FGF21, which prevent onset diseases including The purpose this review clarify how metformin affects MS neuropathology mechanistically via modifying FGF21. Metformin increases expression also β-Klotho, modulates oxidative stress, reduces glutamate-induced excitotoxicity, regulates platelet function coagulation cascades. In conclusion, can enhance functional activity counteracting development progression Preclinical clinical studies warranted regard.

Язык: Английский

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SARS-CoV-2 infection and dysregulation of nuclear factor erythroid-2-related factor 2 (Nrf2) pathway

Cell Stress and Chaperones, Год журнала: 2023, Номер 28(6), С. 657 - 673

Опубликована: Окт. 5, 2023

Coronavirus disease 2019 (COVID-19) is a recent pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) leading to pulmonary and extra-pulmonary manifestations due the development of oxidative stress (OS) hyperinflammation. The underlying cause for OS hyperinflammation in COVID-19 may be related inhibition nuclear factor erythroid 2-related (Nrf2), master regulator antioxidative responses cellular homeostasis. Nrf2 pathway inhibits expression pro-inflammatory cytokines cytokine storm COVID-19. activators can attenuate endothelial dysfunction (ED), renin-angiotensin system (RAS) dysregulation, immune thrombosis, coagulopathy. Hence, this review aimed reveal potential role its management As well, we tried revise mechanistic

Язык: Английский

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Citicoline and COVID-19: vis-à-vis conjectured

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2022, Номер 395(12), С. 1463 - 1475

Опубликована: Сен. 5, 2022

Язык: Английский

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