International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12701 - 12701

Опубликована: Ноя. 26, 2024

Foeniculum vulgare Mill, commonly known as fennel, is an aromatic herb traditionally used for culinary and medicinal purposes, with potential therapeutic effects on neurological disorders. However, limited research has focused its neurotrophic impact, particularly neuronal maturation synaptic development. This study investigates the of F. ethanol extracts (FVSE) rat primary hippocampal neurons. Results show that FVSE prominent component, anethole, significantly promote neurite outgrowth in a dose-dependent manner. Optimal axonal dendritic growth occurred at concentrations 40 µg/mL 20 µM respectively, without causing cytotoxicity, underscoring safety health. Additionally, enhances formation synapses, essential communication. Network pharmacology analysis revealed components influence critical pathways, including PI3K-AKT Alzheimer’s disease pathways. Specifically, modulates key proteins, tropomyosin receptor kinase (Trk), glycogen synthase 3 (GSK3βser9), phosphatidylinositol 3-kinase (PI3K), extracellular signal-regulated protein (Erk1/2). Anethole was found to play role regulating these which confirmed by immunocytochemistry experiments demonstrating effect promoting In conclusion, this highlights properties FVSE, anethole emerging bioactive compound. These findings provide valuable insights into fennel treating disorders, offering basis future interventions survival.

Язык: Английский