Targeting Lkb1-Ampk-Sirt1-Induced Autophagy and Mitophagy Pathways Improve Cerebrovascular Homeostasis in App/Ps1 Mice

Опубликована: Янв. 1, 2025

Язык: Английский

---

Dapagliflozin Improves High‐Fat Diet‐Induced Cognitive Impairment in Female Mice

Brain and Behavior, Год журнала: 2025, Номер 15(2)

Опубликована: Фев. 1, 2025

ABSTRACT Background High fat consumption is a known risk factor for the development of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). Sodium‐glucose cotransporter inhibitors (SGLT2is) have been found to possess anti‐inflammatory neuroprotective properties. However, cognitive effects mechanisms SGLT2is on female mice fed with high‐fat diet remain unknown. Objective This study aimed investigate impacts dapagliflozin metabolism, cognition, neuroinflammation, insulin resistance, microglial activation in HFD. Methods Dapagliflozin (1 mg/kg) was administered HFD‐fed 24 weeks. Body weight, glucose tolerance, resistance were assessed. Additionally, all subjected Morris water maze (MWM) one‐trial Y‐maze tests. The levels metabolic hormones cytokines analyzed using ELISA kits. phosphorylated tau (p‐tau) protein hippocampus measured. Microglia, receptors, NLRP3, IL‐1β evaluated by immunofluorescence or immunohistochemical staining. Results As anticipated, improved metabolism reduced impairment In hippocampus, alleviated yet did not reduce secretion inflammatory chemokines. Furthermore, it increased expression receptor decreased p‐tau. Conclusions Our results provide foundation clinical application as an adjuvant slow down progression central degenerative diseases related disorders, such AD.

Язык: Английский

---

Modulating Multiple Molecular Trajectories by Nutraceuticals and/or Physical Activity in Attention-Deficit/Hyperactivity Disorder (ADHD)-Like Behaviors in Rat Pups

Journal of Neuroimmune Pharmacology, Год журнала: 2025, Номер 20(1)

Опубликована: Март 18, 2025

Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition affecting cognitive and social functions all over childhood. Monosodium glutamate (MSG) common food additive associated with ADHD-like symptoms in children. Nutraceuticals, like sesamol (SE) astaxanthin (AST), or physical activity (PHA) were reported to possess beneficial effects on human health. Meanwhile, still their neuroprotective effect against ADHD has been poorly investigated. This study aimed investigate the impact of SE, AST PHA either separately combined behaviors induced by MSG rat pups. Eighty-four male Sprague Dawley pups randomly allocated into seven groups; control, MSG, (PHA + MSG), (SE (AST (COMB [PHA SE AST] MSG) treated for eight weeks. MSG-induced behavior was evaluated, via assessing behavioral outcomes; neurotransmitters' levels; five pathway biomarkers, coupled histopathological immunohistochemical studies. Rats exposed exhibited enhanced attention, locomotor, abilities, compared MSG-intoxicated group. All treatments remarkably improved abnormalities biochemical markers; along histological findings, modulating HMGB1/RAGE/JAK-2/STAT-3, PI3K/AKT/CREB/BDNF, AMPK/SIRT-1 PERK/CHOP pathways. Nevertheless, combination nutraceuticals AST) elicited more favorable measured parameters other groups. In conclusion, this revealed superiority PHA, standalone treatments, amelioration pups, fine-tuning HMGB1/RAGE,

Язык: Английский

---

Sodium-glucose cotransporter 2 inhibitor partially improves brain mitochondrial function, but does not mitigate cognitive impairment in rats with myocardial infarction

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2025, Номер unknown, С. 167809 - 167809

Опубликована: Март 1, 2025

Язык: Английский

---

Targeting LKB1–AMPK–SIRT1–induced autophagy and mitophagy pathways improves cerebrovascular homeostasis in APP/PS1 mice

Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

---