Synergism Between Essential Oils and Evaluation of Their Activities with a Focus on Malassezia furfur Control

Planta Medica, Год журнала: 2023, Номер 90(02), С. 111 - 125

Опубликована: Ноя. 7, 2023

Abstract Seborrheic dermatitis is a chronic inflammatory disease caused by Malassezia yeast species that affects the regions of body where sebaceous glands are present. The combined use different essential oils (EOs) can increase their spectrum action. Thus, present study aimed to evaluate action EOs alone and in combination with each other on M. furfur, planktonic biofilm form, anti-inflammatory mutagenic potential, addition effects viability cells lines. Of 40 evaluated EOs, 22 showed activity against furfur at 0.5 – 2.0 mg/mL concentrations. Among most active species, blend (BEOs) composed Cymbopogon martini (Roxb.) Will. Watson (MIC = mg/mL) Mentha × piperita L. 1.0 was selected, which synergistic effect when through checkerboard assay. fungicidal maintained oil from Varronia curassavica Jacq. BEOs. BEOs also inhibition formation eradication formed being superior fluconazole. Furthermore, it did not show potential interfere cell both lines (HaCaT BMDMs). TNF-α levels were reduced only C. martini; however, this property evaluating had no IL-8 levels. may be indicated for alternative treatments seborrheic dermatitis.

Язык: Английский

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Chitosan Film Loaded with Carbon Dots and Geraniol/Hydroxypropyl-Β-Cyclodextrin Inclusion Complex: Simultaneous Freshness Preservation and Quality Monitoring of Meat Products

Опубликована: Янв. 1, 2024

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Язык: Английский

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Chitosan film loaded with carbon dots and geraniol/hydroxypropyl-β-cyclodextrin inclusion complex: Simultaneous freshness preservation and quality monitoring of pork

Food Hydrocolloids, Год журнала: 2024, Номер 157, С. 110326 - 110326

Опубликована: Июнь 14, 2024

Язык: Английский

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Particle size of Cymbopogon Nardus powder affect Geraniol extracted by Novel Extraction Method using hard cap Espresso Machine

Research Journal of Pharmacy and Technology, Год журнала: 2024, Номер unknown, С. 4169 - 4176

Опубликована: Сен. 24, 2024

Espresso machine is proven to be effective extract compound from herbal plants in small scale. Particle size one of critical parameters affecting amount bioactive extracted the plants. Therefore, this study, a novel and economical pressurized liquid extraction method based on hard caps espresso has been developed. Cymbopogon nardus powder with various particle (mesh sizes 40/60, 60/80 100/120) were 40mL water for 12-40 seconds using machine. Geraniol content obtained extracts then determined by gas chromatography paired tandem mass spectrometry (GC-MS). This study showed that geraniol C. mesh 100/120 37.4; 44.7 23.5mg/g, respectively. The highest was found powder. result indeed affect concentration developed proved fast, efficient reliable. Further should performed find optimum process

Язык: Английский

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Geraniol Ameliorates Pentylenetetrazol-Induced Epilepsy, Neuroinflammation, and Oxidative Stress via Modulating the GABAergic Tract: In vitro and in vivo studies

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 5655 - 5672

Опубликована: Дек. 1, 2024

Introduction: Geraniol (Ger), a monoterpene, is common constituent of several essential oils. This study explored the anticonvulsant effect Ger in-vitro using nerve growth factor (NGF) prompted PC12 cell injured by Glutamate (Glu) and in-vivo Pentylenetetrazole (PTZ)-induced kindling through GABAergic pathway. Materials: To assess on NGF cells Glu, at concentrations 25, 50, 100, 200 400 μg/mL was used. GABA, 5-HT, IL-1β, IL-4, TNF-α levels gene expressions GABAA-Rα 1, NMDAR1, GAD 65, 67, GAT 1 3 were measured in NGF-induced treated with (100, μg/mL). Mice randomly separated into five groups. Normal PTZ groups which mice injected saline or PTZ, respectively. + SV orally administered sodium valproate (SV), respectively, then PTZ. Results: up to did not display any toxicity injury cells. (100 μg/mL) reduced induced increased expression GAD65 GAD67 decreased NMDAR1 damaged Glu. GABA TNF-α, IL-4 IL-1β As for results, GAD, lowered T. mitigated MDA, NO, IL-6, IFN-γ, GFAP, caspase-3, − 9 Bax escalated GSH, SOD, catalase, BDNF Bcl2 expression. Conclusion: oxidative stress status, neuroinflammation apoptosis activated neurotransmission, might clarify its anticonvulsant. protects animals against as established enhancement short term well long-term memory. Glu cell. Keywords: geraniol, pentylenetetrazole, GABAergic, stress, neuroinflammation,

Язык: Английский

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In Silico Docking Study of Guttiferones; Q-S from Malabar Tamarind Fruit Rind Against SARS-Cov-2 Omicron Spike Protein with Evaluation of Antioxidant Potential, Phenolic Content and HPTLC Fingerprinting of Its Total Extract

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Июль 24, 2023

Abstract (1) Background : The Omicron variant of SARS-CoV-2 has rapidly spread and is now the predominant worldwide. Its key feature its ability to evade immunity from natural infection or vaccines, owing numerous mutations in spike protein. In contrast, medicinal plants have been utilized as alternative therapies alleviate certain signs symptoms associated with COVID-19. this study; Malabar tamarind, which belongs Clusiaceae family, was studied for HPTLC fingerprint total methanolic extract, quantitative determination phenolics flavonoids, in-vitro evaluation antioxidant potential, followed by molecular docking study three reported metabolites; Guttiferones Q, R S, order measure their affinity against target site Spike Protein (2) Methods Total phenolic content evaluated Folin-Catechu assay, flavonoids aluminum chloride assay. Antioxidant potential estimated DPPH while silico processed use Azithromycin a reference drug (3) Results Tamarind exhibited free radical-scavenging activity 71.75 % inhibition. results suggested that Guttiferone highest binding affinity, alongside predicted energy -8.67 kcal/mol an RMSD value 1.07 Å compared Azithromycin, compound, -8.90 1.20 Å. (4) Conclusions strongest candidate, based on high low value, suggests it stable mode.

Язык: Английский

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Biochemical and Preclinical Evaluation with Synthesis and Docking Study of Pyridopyrimidines and Selenium Nanoparticle Drugs for Cancer Targeting

Current Nanoscience, Год журнала: 2023, Номер 21(3), С. 498 - 510

Опубликована: Дек. 30, 2023

Background: Ultrasonic irradiation has the remarkable potential to amplify reactivity by a factor of approximately one million. The effects ultrasound on chemical processes can be categorized as either homogeneous sonochemistry, which takes place in liquids, or heterogeneous occurs liquid-liquid liquid-solid systems. Objectives: Pyrimidines are vital group compounds known for their anticancer activities. This study delves into investigating application ultrasonic synthesis pyridopyrimidine derivatives. Methods: In our study, we utilized pyrimidine derivatives 1, 2a, and 2b reducing agents during creation selenium nanoparticles (Het-SeNPs). characterization these was executed through range analytical approaches, including ultraviolet-visible spectrometry, dynamic light scattering (DLS, Zeta), transmission electron microscopy (TEM). Additionally, FTIR NMR spectroscopic examinations provided proof formation within synthesized molecules 2b. Results: impact produced heterocyclic Het-SeNPs assessed various cancer cell lines, breast (MCF-7), liver (HepG2), prostate (PC-3) lines. All tested substances demonstrated reasonable level safety HFB4 line, represents normal human skin melanocytes. Noteworthy is substantial cytotoxicity exhibited compound against MCF-7 Conclusion: Moreover, 2b-SeNPs even higher line compared 2b, where 5-fluorouracil used reference standard. Detailed division analysis disclosed significant antiproliferative properties 2b-SeNPs, leading arrest cycle at pre-G1 G2/M phases.

Язык: Английский

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