Frontiers in Integrative Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Июль 12, 2024
The
SARS-CoV-2
pandemic
has
affected
771
million
people
and
caused
6.9
confirmed
deaths
as
of
November
2023.
Beyond
the
adversity,
a
crucial
less-explored
chapter
unfolds:
adaptive
sequelae.
These
have
altered
social,
mental,
emotional
conditions,
leaving
an
imprint
on
biological
systems.
While
some
cases
fully
resolve
pathological
process
post-acute
infection,
others
persist
with
symptoms,
posing
challenge
that
underscores
need
to
comprehend
pathophysiology
from
innovative
perspectives.
article
delves
into
“Long
COVID”
or
Post-Acute
COVID-19
Syndrome
(PACS),
where
symptoms
for
≥4
weeks
irrespective
initial
severity.
Risk
factors
include
history
severe
illness,
in-hospital
management,
intensive
care.
This
also
explores
theories,
derived
various
experimental
models,
demonstrated
involvement
nervous
system
in
coordination
psychoneuroimmunoendocrine
axes
expression
inflammation.
It
is
posited
PACS
involves
processes
peripheral
central
sensitization
(corticalization),
facilitating
dishomeostasis
chronicity
inflammatory
process.
In
this
context,
therapeutic
strategies
grounded
modulating
reflex
are
reviewed,
primarily
through
infiltration
local
anesthetics
via
linear
non-linear
approaches.
Neural
use
considered
stimulate
regulatory
circuits
coordinated
by
neuroimmune-endocrine
system.
Nutrients,
Год журнала:
2025,
Номер
17(5), С. 800 - 800
Опубликована: Фев. 26, 2025
During
the
COVID-19
pandemic,
dietary
habits
in
population
changed
and
sometimes
deviated
from
healthy
eating
patterns,
such
as
Mediterranean
diet.
Based
on
reports
quality
of
diet
respondents
to
studies
conducted
at
beginning
it
could
be
concluded
that
these
new
are
unfavorable
for
a
good
prognosis
course
any
disease
its
severity
symptoms.
This
study
decided
confront
assumptions
with
results
people
who
had
COVID-19.
Background/Objectives:
aimed
assess
associations
between
patterns
occurrence
hospitalization
gastrointestinal
disorders
among
patients
diagnosed
Methods:
included
550
completed
survey
up
8
months
after
being
The
62
items
FFQ-6®,
GSRS,
PAC-SYM
FACT-G7
standardized
questionnaires.
Results:
Two
(DPs)
were
identified:
'Processed
high
fat/sugar/salt/meat/dairy/potatoes'
'Semi-vegetarian'.
Higher
adherence
'Processed'
DP
was
associated
higher
odds
due
COVID-19,
more
severe
disease,
highest
intensity
'Semi-vegetarian'
lower
less
lowest
Conclusions:
showed
strong
harmful
effect
processed
pattern
an
increased
incidence
northwestern
Polish
adults
during
emphasizing
importance
Nutrients,
Год журнала:
2025,
Номер
17(7), С. 1287 - 1287
Опубликована: Апрель 7, 2025
Long
COVID,
characterized
by
persistent
symptoms
following
COVID-19
infection,
significantly
impacts
individuals'
health
and
daily
functioning
due
to
fatigue
pain.
Focusing
on
pain,
this
review
addresses
nociplastic
chronic
pain
conditions.
Interventions
designed
reduce
inflammation,
oxidative
stress,
enhance
vagal
activity
may
offer
a
promising
approach
managing
post-pandemic
This
presents
individual
components
of
food
supplements
with
demonstrated
efficacy
in
one
or
more
conditions,
focusing
their
proposed
mechanisms
clinical
including
use
post-COVID-19
when
available.
Many
these
substances
have
long
history
safe
an
alternative
long-term
analgesic
drug
treatment,
which
is
often
associated
potential
side
effects.
also
explores
the
for
synergistic
effects
combining
each
other
conventional
analgesics,
considering
advantages
both
patients
healthcare
system
using
as
adjunctive
primary
therapies
related
COVID.
While
preclinical
scientific
literature
provides
mechanistic
basis
action
several
control
signaling
pathways,
experience,
particularly
field
COVID-associated
still
limited.
However,
reviewed
strongly
suggests
that
attainable
goal,
provided
rigorous
trials
are
conducted.
The Italian Journal of Pediatrics/Italian journal of pediatrics,
Год журнала:
2025,
Номер
51(1)
Опубликована: Апрель 16, 2025
Abstract
Background
Post-COVID
Condition
(PCC),
emerging
as
a
significant
long-term
consequence
of
SARS-CoV-2
infection,
affects
not
only
adults
but
also
the
pediatric
population.
Despite
ongoing
research,
precise
pathophysiology
PCC
remains
elusive.
However,
several
putative
mechanisms
have
been
identified,
leading
to
exploration
various
therapeutic
strategies.
Notably,
in
adult
population,
there
has
substantial
interest
potential
efficacy
nutritional
supplements.
Regrettably,
information
regarding
use
such
supplements
population
is
currently
lacking.
Methods
The
present
study
was
conducted
assess
impact
on
alleviating
long
COVID
symptoms
children.
To
achieve
this,
we
retrospective
analysis
nutrient
administered
by
parents
children
with
(PCC)
between
February
2020
and
October
2022.
Statistical
analyses
were
employed
determine
associations
categorical
variables.
Results
A
total
1243
enrolled
following
documented
940
(76.2%)
diagnosed
recovered
294
(23.8%)
Long
COVID.
Among
patients
experiencing
disabling
symptoms,
treatment
oral
lactoferrin
and/or
Multi-Element
Product
(MEP)
antioxidant
anti-inflammatory
properties
initiated.
correlation
persistence
at
next
follow-up
showed
that
MEP
alone
(OR
5.7,
95%
CI
3.8–8.5),
or
combination
5.06,
3.3–7.6)
three
months
after
initial
infection
for
months,
associated
lower
risk
having
covid
six
when
compared
7.6
5.1–11.4).
Conclusions
This
proof-of-concept
revealed
lactoferrin,
new
diagnosis
covid,
may
positive
improving
during
evaluations.
trend
toward
reducing
exhibited
suggested
benefit
worthy
future
randomized
controlled
trials.
Antioxidants,
Год журнала:
2023,
Номер
12(11), С. 1942 - 1942
Опубликована: Окт. 31, 2023
Zinc
is
a
structural
component
of
proteins,
functions
as
catalytic
co-factor
in
DNA
synthesis
and
transcription
hundreds
enzymes,
has
regulatory
role
protein-DNA
interactions
zinc-finger
proteins.
For
many
years,
zinc
been
acknowledged
for
its
anti-oxidative
anti-inflammatory
functions.
Furthermore,
potent
inhibitor
caspases-3,
-7,
-8,
modulating
the
caspase-controlled
apoptosis
necroptosis.
In
recent
immunomodulatory
sepsis
COVID-19
investigated.
Both
are
related
to
various
regulated
cell
death
(RCD)
pathways,
including
Lack
may
have
negative
effect
on
immune
functions,
such
oxidative
burst,
cytokine
production,
chemotaxis,
degranulation,
phagocytosis,
RCD.
While
plasma
concentrations
decline
swiftly
during
both
COVID-19,
this
reduction
primarily
attributed
redistribution
process
associated
with
inflammatory
response.
response,
hepatic
metallothionein
production
increases
reaction
release,
which
linked
inflammation,
protein
effectively
captures
stores
liver.
Multiple
mechanisms
come
into
play,
influencing
uptake
zinc,
binding
blood
albumin
red
cells,
well
buffering
modulation
cytosolic
levels.
Decreased
levels
increasing
severity
organ
dysfunction,
prolonged
hospital
stay
increased
mortality
septic
patients.
Results
studies
focusing
these
topics
summarized
discussed
narrative
review.
Existing
evidence
currently
does
not
support
pharmacological
supplementation
patients
or
COVID-19.
Complementation
repletion
should
follow
current
guidelines
micronutrients
critically
ill
Further
research
investigating
mechanism
programmed
caused
by
invasive
infections
therapeutic
potential
could
be
worthwhile.
Clinics and Practice,
Год журнала:
2024,
Номер
14(3), С. 892 - 905
Опубликована: Май 17, 2024
Background:
Nutritional
status’s
role
in
long
COVID
is
evident
the
general
population,
yet
unexplored
patients
undergoing
hemodialysis
(HD),
posing
a
research
gap.
We
hypothesized
that
pre-infection
undernutrition
HD
might
impact
persistence
by
accelerating
oxidative
stress.
The
present
study
aimed
to
investigate
association
between
nutritional
status,
stress,
and
one-year-long
patients.
Methods:
This
prospective
observational
cohort
enrolled
115
with
confirmed
COVID-19.
status
was
assessed
using
Controlling
Status
(CONUT)
score
twice:
before
infection
three
months
post-infection.
Oxidative
markers
included
malondialdehyde
(MDAs),
ceruloplasmin,
transferrin,
sulfhydryl
groups.
endpoint
persistence.
Results:
Moderate
CONUT
scores
were
associated
heightened
severe
risk
(p
<
0.0001),
elevated
MDAs
reduced
ceruloplasmin
levels
=
0.0009)
at
post-COVID-19
compared
light
scores.
Pre-infection
independently
predicted
post-COVID
damage
[OR
2.3
(95%
CI
1.2;
4.6),
p
0.0001]
[HR
4.6
1.4;
9.9),
0.0001],
even
after
adjusting
for
potential
confounders.
Conclusion:
heightens
stress
increases
of
Long
Covid
is
a
debilitating
condition
that
has
been
well-documented
over
the
past
4
years
and
shares
many
similarities
with
other
post-viral
chronic
illnesses.
Despite
this,
clinicians
are
not
confident
in
recognising
signs
of
Covid,
or
effectively
managing
symptoms
their
patients.
This
paper
presents
single
patient
case
report
from
biomedical
researcher
who
had
for
2
years;
it
written
relatively
plain
language
to
be
accessible
both
patients
across
multiple
specialities.
The
author
ability
expertise
keep
up
research
literature,
cobbled
together
management
strategy
alleviated
her
own
symptoms,
those
people
whom
she
shared
protocol.
author’s
experience
developing
presented
here,
hopes
may
assistance
identifying
Inflammopharmacology,
Год журнала:
2024,
Номер
32(2), С. 945 - 948
Опубликована: Янв. 31, 2024
Abstract
Chronic
tinnitus
is
a
common
neurological
disorder
that
affects
millions
of
patients
globally
with
no
available
successful
pharmacotherapy.
It
can
be
extremely
bothersome
to
some
the
extent
it
occasionally
qualifies
as
disability
hinder
them
from
leading
normal
life.
In
this
short
communication,
author
discusses
how
he
suffered
idiopathic
and
managed
adopt
combined
pathophysiological
pharmacological
approach
reason
for
first
time
in
medical
literature
low-dose
metformin
might
safely
effectively
repurposed
manage
at
least
subset
while
discussing
potential
role
adenosine
receptor
agonists
future
therapeutics.
British Journal Of Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 13
Опубликована: Июнь 3, 2024
Abstract
The
epidemiological
and
burden
characteristics
of
nutritional
deficiencies
(ND)
have
been
evolving,
it
is
crucial
to
identify
geographical
disparities
emerging
trends.
This
study
aimed
analyse
the
global,
regional
national
trends
in
ND
over
past
30
years.
Data
were
obtained
from
Global
Burden
Disease
(GBD)
2019
database
for
period
1990–2019.
examined
incidence
rates
disability-adjusted
life
years
(DALY)
at
various
levels.
Globally,
rate
decreased
2226·2
per
100
000
2096·3
same
year,
indicating
a
decline
5·8
%.
average
annual
percentage
change
(AAPC)
was
−0·21
(–0·31,
−0·11).
Similarly,
DALY,
prevalence
mortality
exhibited
significant
declines
(AAPC
=
−3·21
(–3·45,
−2·96),
AAPC
−0·53
(–0·55,
−0·51)
−4·97
(–5·75,
−4·19),
respectively).
varied
based
on
age
group,
sex,
cause
area.
Moreover,
negative
association
observed
between
sociodemographic
index.
At
level,
South
Asia
sub-Saharan
Africa
regions
had
highest
ND.
In
conclusion,
global
showed
mixed
pattern,
while
DALY
consistently
declined.
Additionally,
1990
2019.
Background:
Nutritional
status
and
oxidative
stress
have
been
implicated
in
the
pathogenesis
persistence
of
long
COVID,
but
data
patients
undergoing
hemodialysis
(HD)
are
limited.
The
present
study
aimed
to
investigate
association
between
pre-infection
nutritional
status,
stress,
one-year
COVID
HD
patients.
Methods:
This
prospective
observational
cohort
enrolled
115
with
confirmed
COVID-19.
was
assessed
using
Controlling
Status
(CONUT)
score
twice:
before
infection
three
months
post-infection.
Oxidative
markers
included
malondialdehyde
(MDAs),
ceruloplasmin,
transferrin,
sulfhydryl
groups.
endpoint
persistence.
Results:
Moderate
CONUT
scores
were
associated
heightened
severe
undernutrition
risk
(p
&lt;
0.0001),
elevated
MDAs
reduced
ceruloplasmin
levels
=
0.0009)
at
post-COVID-19
compared
light
scores.
Pre-infection
independently
predicted
post-COVID
damage
[OR
2.3
(95%CI
1.2;
4.6),
p
0.0001]
[HR
4.6
1.4;
9.9),
0.0001],
even
after
adjusting
for
potential
confounders.
Conclusion:
increased
intensity
