BMC Endocrine Disorders,
Год журнала:
2024,
Номер
24(1)
Опубликована: Ноя. 25, 2024
Prior
studies
indicated
the
positive
effects
of
probiotics
on
glycemic
regulation
in
patients
with
gestational
diabetes
mellitus
(GDM).
Nonetheless,
results
remain
inconclusive.
To
address
this,
we
conducted
an
umbrella
meta-analysis
to
evaluate
impact
indicators
GDM.
A
comprehensive
search
was
PubMed
and
Scopus
databases
identify
all
relevant
meta-analyses
randomized
clinical
trials
published
until
July
2024.
The
outcomes
included
serum
hemoglobin
A1C
(HbA1c),
fasting
blood
insulin
(FBI),
sugar
(FBS),
homeostatic
model
assessment
for
resistance
(HOMA-IR),
quantitative
sensitivity
check
index
(QUICKI),
beta
cell
function
(HOMA-B),
C-peptide,
oral
glucose
tolerance
test
(OGTT).
Standardized
mean
difference
(SMD)
used
effects.
In
total,
27
studies,
comprising
33,378
participants,
were
analysis.
Probiotics
resulted
a
significant
decrease
FBS
(SMD:
-0.39,
95%
CI:
-0.56
-0.23),
especially
when
administered
≤
7
weeks.
Significant
reductions
also
observed
FBI
-1.99,
-2.41
-1.58),
HOMA-IR
-0.61,
-0.72
-0.50),
HOMA-B
-24.58,
-30.59
-18.56).
Moreover,
supplementation
significantly
improved
QUICKI
0.007,
0.004
0.01).
There
evidence
heterogeneity
publication
bias.
No
1-h
OGTT,
2-h
HbA1c,
C-peptide.
dose-specific
effect
observed.
Supplementation
could
improve
control
women
HOMA-IR,
HOMA-B,
clinically
important,
while,
their
not
important.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Сен. 11, 2024
In
recent
years,
the
lung-gut
axis
has
received
increasing
attention.
The
oxidative
stress
and
systemic
hypoxia
occurring
in
chronic
obstructive
pulmonary
disease
(COPD)
are
related
to
gut
dysfunction.
That
suggests
probiotics
have
a
potential
therapeutic
role
COPD.
this
study,
we
therefore
evaluated
ameliorative
effects
of
on
Probiotics and Antimicrobial Proteins,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 19, 2024
The
disparity
between
increased
lifespan
and
healthy
aging,
marked
by
prevalent
"inflammaging",
highlights
the
global
challenge
in
care
of
older
persons.
This
study
explored
anti-inflammatory
effects
Lactiplantibacillus
plantarum
HEAL9
(LpHEAL9),
alone
or
combined
with
berries,
on
volunteers
chronic
low-grade
inflammation
(LGI).
It
was
a
randomized,
double-blind,
placebo-controlled
trial,
total
66
(>
70
years
old),
randomly
assigned,
equally
distributed,
to
placebo,
LpHEAL9
+
Berries
group.
After
2-week
run-in
period,
participants
underwent
4-week
dietary
intervention.
Intake
showed
trend
towards
reduction
serum
CRP
but
without
reaching
statistical
significance.
However,
significantly
decreased
fecal
calprotectin
levels
compared
placebo.
LpHEAL9+Berries
did
not
show
any
effect
inflammation.
Both
probiotic
groups
improving
cognitive
function
albeit
Our
findings
suggest
that
strain
L.
has
modest
impact
LGI
population
(ClinicalTrials.gov
ID:
NCT02342496).
Current Therapeutic Research,
Год журнала:
2024,
Номер
102, С. 100772 - 100772
Опубликована: Дек. 31, 2024
Patients
with
metabolic
disorders
benefit
from
using
anthocyanins.
Nevertheless,
the
findings
drawn
extant
trials
remain
contentious.
Thus,
this
meta-analysis
evaluated
anthocyanin's
effect
on
inflammatory
biomarkers
in
patients
disorders.
We
comprehensively
searched
electronic
databases,
including
PubMed,
Scopus,
Web
of
Science,
and
CENTRAL,
their
inception
to
June
14,
2024.
A
total
11
randomized
controlled
clinical
14
arms
were
analyzed.
There
was
no
significant
anthocyanin
supplementation
interleukin
(IL)-1β
levels
(standardized
mean
difference
[SMD]
=
-0.01,
95%
CI:
-0.33,
0.31;
P
0.941,
I
2
62.4%,
0.031),
tumor
necrosis
factor-α
(TNF-α)
(SMD
-0.49,
-1.07,
0.09;
0.098,
94.0%,
<
0.001)
IL-6
-0.69,
-1.45,
0.06;
0.073,
95.2%,
0.001),
respectively.
between-study
heterogeneity
identified,
which
reduced
when
subgrouping
by
sample
size,
dosage,
study
population.
However,
subgroup
analysis
showed
that
it
might
decrease
TNF-α
hypertension,
if
intervention
lasted
less
than
12
weeks.
impact
IL-1β,
TNF-α,
IL-6;
however,
should
be
noted
has
a
decreasing
individuals
hypertension.
Our
observed
sizes
are
not
clinically
important.
Journal of Dental Research Dental Clinics Dental Prospects,
Год журнала:
2024,
Номер
18(2), С. 152 - 156
Опубликована: Июнь 24, 2024
Ulcers
caused
by
mucosal
irritation
of
fixed
orthodontic
appliances
remain
an
unsolved
problem,
and
more
research
is
needed
to
improve
the
pain
provide
comfortable
treatment
for
these
patients.
This
study
investigated
effect
probiotic
Lactogum
on
ulceration
in
patients
undergoing
treatment.
Inflammatory
processes
are
key
factors
in
pathological
events
associated
with
severe
traumatic
brain
injury
(STBI).
The
aim
of
this
trial
was
to
determine
the
effect
probiotics
on
anthropometric
measures,
disease
severity,
inflammatory
markers,
and
T
cells
patients
STBI.
BMC Endocrine Disorders,
Год журнала:
2024,
Номер
24(1)
Опубликована: Ноя. 25, 2024
Prior
studies
indicated
the
positive
effects
of
probiotics
on
glycemic
regulation
in
patients
with
gestational
diabetes
mellitus
(GDM).
Nonetheless,
results
remain
inconclusive.
To
address
this,
we
conducted
an
umbrella
meta-analysis
to
evaluate
impact
indicators
GDM.
A
comprehensive
search
was
PubMed
and
Scopus
databases
identify
all
relevant
meta-analyses
randomized
clinical
trials
published
until
July
2024.
The
outcomes
included
serum
hemoglobin
A1C
(HbA1c),
fasting
blood
insulin
(FBI),
sugar
(FBS),
homeostatic
model
assessment
for
resistance
(HOMA-IR),
quantitative
sensitivity
check
index
(QUICKI),
beta
cell
function
(HOMA-B),
C-peptide,
oral
glucose
tolerance
test
(OGTT).
Standardized
mean
difference
(SMD)
used
effects.
In
total,
27
studies,
comprising
33,378
participants,
were
analysis.
Probiotics
resulted
a
significant
decrease
FBS
(SMD:
-0.39,
95%
CI:
-0.56
-0.23),
especially
when
administered
≤
7
weeks.
Significant
reductions
also
observed
FBI
-1.99,
-2.41
-1.58),
HOMA-IR
-0.61,
-0.72
-0.50),
HOMA-B
-24.58,
-30.59
-18.56).
Moreover,
supplementation
significantly
improved
QUICKI
0.007,
0.004
0.01).
There
evidence
heterogeneity
publication
bias.
No
1-h
OGTT,
2-h
HbA1c,
C-peptide.
dose-specific
effect
observed.
Supplementation
could
improve
control
women
HOMA-IR,
HOMA-B,
clinically
important,
while,
their
not
important.
