Asian Journal of Pharmaceutical Research and Health Care,
Год журнала:
2024,
Номер
16(4), С. 344 - 351
Опубликована: Окт. 1, 2024
A
BSTRACT
Even
with
the
swift
progress
in
scientific
understanding
of
various
diseases
such
as
cancer,
cardiovascular
diseases,
and
diabetes,
there
remains
a
need
for
effective
new
treatments.
Now,
other
drug
development
strategies,
repurposing
existing
medicines
to
treat
which
will
save
time
money,
are
being
investigated.
Since
metformin
is
one
most
used
drugs
worldwide
it
investigated
uses,
therefore,
this
review
potential
uses
beyond
its
established
use
diabetes
highlighted
several
polycystic
ovary
syndrome
(PCOS),
weight
reduction,
lowering
plasma
lipids,
delaying
aging
process,
possible
role
reducing
mortality
pandemic
COVID-19.
An
extensive
literature
search
was
conducted
on
PubMed
Google
Scholar
databases
identify
relevant
literature.
Viruses,
Год журнала:
2024,
Номер
16(11), С. 1795 - 1795
Опубликована: Ноя. 19, 2024
Long
COVID
or
Post-Acute
Sequelae
of
SARS-CoV-2
infection
(PASC)
is
a
condition
characterized
by
numerous
lingering
symptoms
that
persist
for
weeks
to
months
following
the
viral
illness.
While
treatment
PASC
still
evolving,
several
therapeutic
approaches
beyond
traditional
antiviral
therapies
are
being
investigated,
such
as
immune-modulating
agents,
anti-inflammatory
drugs,
and
various
supportive
interventions
focusing
at
alleviating
enhancing
recovery.
We
aimed
summarize
breadth
available
evidence,
identify
knowledge
gaps,
highlight
promising
non-antiviral
COVID/PASC.
followed
framework
scoping
methodology
mapping
existing
evidence
from
range
studies,
including
randomized
clinical
trials,
observational
research,
case
series.
Treatments
evaluated
include
metformin,
low-dose
naltrexone
(LDN),
dexamethasone,
statins,
omega-3
fatty
acids,
L-arginine,
emerging
like
intravenous
immunoglobulin
(IVIg)
apheresis.
Early
findings
suggest
metformin
has
strongest
particularly
large
phase
3
while
LDN
dexamethasone
show
potential
based
on
studies.
However,
many
treatments
lack
robust,
large-scale
trials.
This
review
emphasizes
need
further
research
confirm
efficacy
these
guide
practice
management.
Asian Journal of Pharmaceutical Research and Health Care,
Год журнала:
2024,
Номер
16(4), С. 344 - 351
Опубликована: Окт. 1, 2024
A
BSTRACT
Even
with
the
swift
progress
in
scientific
understanding
of
various
diseases
such
as
cancer,
cardiovascular
diseases,
and
diabetes,
there
remains
a
need
for
effective
new
treatments.
Now,
other
drug
development
strategies,
repurposing
existing
medicines
to
treat
which
will
save
time
money,
are
being
investigated.
Since
metformin
is
one
most
used
drugs
worldwide
it
investigated
uses,
therefore,
this
review
potential
uses
beyond
its
established
use
diabetes
highlighted
several
polycystic
ovary
syndrome
(PCOS),
weight
reduction,
lowering
plasma
lipids,
delaying
aging
process,
possible
role
reducing
mortality
pandemic
COVID-19.
An
extensive
literature
search
was
conducted
on
PubMed
Google
Scholar
databases
identify
relevant
literature.
