Bauhinia coccinea extract prevents memory loss induced by scopolamine through activation of antiapoptotic and antioxidant pathways in mice
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 3, 2025
Alzheimer's
disease
(AD)
is
characterized
by
oxidative
stress-mediated
memory
dysfunction
and
neuronal
cell
death.
This
study
investigated
the
effects
of
an
ethanol
extract
from
Bauhinia
coccinea
(EEBC)
on
impairment
damage
in
a
deficit
mouse
model.
EEBC
was
administered
to
ICR
mice
at
doses
50,
100,
or
200
mg/kg
daily
for
3
weeks.
Cognitive
induced
via
scopolamine
(SCO)
injection.
Brain
tissues
were
analyzed
acetylcholine
(ACh)
levels,
acetylcholinesterase
(AChE)
activity,
apoptosis,
antioxidant
markers.
Behavioral
tests
showed
that
SCO
injection
loss,
whereas
significantly
ameliorated
SCO-mediated
impairment.
regulated
cholinergic
system
decreasing
ACh
levels
enhancing
AChE
activity.
Nissl
staining
immunohistochemistry
NeuN
exerted
neuroprotective
SCO-injected
brains.
Moreover,
reduced
number
terminal
deoxynucleotidyl
transferase
dUTP
nick
end
labeling-positive
apoptotic
cells
increased
treatment.
also
reversed
SCO-induced
changes
apoptosis-related
protein
expression
brain
tissues.
Furthermore,
malondialdehyde
activated
catalase
SCO-administered
Quantitative
RNA
sequencing
involvement
lipid
metabolism
function
regulation.
Thus,
promising
candidate
attenuating
AD
progression
as
it
targets
apoptosis.
Язык: Английский
Unveiling the neuroprotective potential of Ipomoea carnea ethanol extract via the modulation of tau and β-secretase pathways in AlCl3-induced memory impairment in rats in relation to its phytochemical profiling
Inflammopharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Abstract
Alzheimer’s
disease
(AD)
is
a
widespread
condition
that
affects
adults
and
the
community
considerably.
The
causes
are
yet
unknown,
except
from
advanced
age
genetic
predisposition.
Natural
products
provided
advantageous
advantages
for
managing
AD
due
to
their
efficacy,
safety,
accessibility.
memory
boosting
effects
of
chemically
characterized
Ipomoea
carnea
ethanol
extract
(IPC-EtOH)
on
behavioral,
biochemical,
histological,
molecular
levels
against
cognitive
impairment
induced
by
AlCl
3
exposure
in
rats
were
assessed
using
donepezil
as
reference
drug.
Behavioral
tests
(spontaneous
alternation
T-maze
open
field
test)
assays
GSK3β,
CREB,
FOXO1a,
β-secretase,
tau,
oxidative
stress
biomarkers,
histopathology,
immunohistochemistry
cyclooxygenase
2
(COX-2)
conducted.
chemical
profiling
IPC-EtOH
UPLC-ESI–qTOF-MS
coupled
with
networking
revealed
identification
83
bioactive
metabolites,
including
pyrrolizidine
alkaloids
cinnamic
acid
derivatives
which
previously
undescribed
this
species.
injection
significantly
elevated
β
-secretase,
GSSG,
GSK-3
,
FOXO3a
down
regulated
CAT,
SOD,
strong
COX-2
immunoexpression
cortex
hippocampus
compared
controls.
Oral
co-administration
or
-treated
restored
near-normal
function
these
brain
regions,
attenuating
spatial
learning,
memory,
locomotor
impairments.
These
results
suggest
could
be
promising
therapy
mitigating
aluminum-induced
neurotoxicity,
though
further
studies
needed
elucidate
its
precise
mechanisms
action.
outcomes
emphasize
I.
extract’s
potential
an
appealing
demonstrating
neuroprotective
memory-enhancing
properties
having
-induced
impairment.
Язык: Английский
The role of Foxo3a in neuron-mediated cognitive impairment
Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Июнь 19, 2024
Cognitive
impairment
(COI)
is
a
prevalent
complication
across
spectrum
of
brain
disorders,
underpinned
by
intricate
mechanisms
yet
to
be
fully
elucidated.
Neurons,
the
principal
cell
population
nervous
system,
orchestrate
cognitive
processes
and
govern
balance.
Extensive
inquiry
has
spotlighted
involvement
Foxo3a
in
COI.
The
regulatory
cascade
transactivation
implicates
multiple
downstream
signaling
pathways
encompassing
mitochondrial
function,
oxidative
stress,
autophagy,
apoptosis,
collectively
affecting
neuronal
activity.
Notably,
expression
activity
profile
are
subject
modulation
via
various
modalities,
including
methylation
promoter,
phosphorylation
acetylation
protein.
Furthermore,
upstream
such
as
PI3K/AKT,
SIRT
family,
diverse
micro-RNAs
intricately
interface
with
Foxo3a,
engendering
alterations
function.
Through
several
routes,
regulates
dynamics,
thereby
modulating
onset
or
amelioration
COI
Alzheimer’s
disease,
stroke,
ischemic
injury,
Parkinson’s
traumatic
injury.
potential
therapeutic
target,
clinical
drugs
small
molecules
have
been
preliminarily
shown
cognitive-enhancing
effects
that
indirectly
affect
Foxo3a.
Particularly
noteworthy
randomized,
controlled,
placebo
trials
illustrating
significant
enhancement
achievable
through
autophagy
modulation.
Here,
we
discussed
role
neuron-mediated
common
cognitively
impaired
diseases.
Язык: Английский
Myricetin-Loaded SBA-15 silica nanoparticles for enhanced management of Pyrexia, pain, and inflammation through modulation of MAPK/NF-kB and COX-2/PGE-2 pathways: Evidence from the biochemical, histological, and metabolomic analysis
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
unknown, С. 124775 - 124775
Опубликована: Сен. 1, 2024
Язык: Английский
Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats
Endocrine and Metabolic Science,
Год журнала:
2025,
Номер
unknown, С. 100235 - 100235
Опубликована: Март 1, 2025
Язык: Английский
Deregulation of Neuroinflammatory and Neurotrophic Factors as Biological Events Triggered by D-Galactose Chronic Administration in Wistar Rats
NeuroMolecular Medicine,
Год журнала:
2025,
Номер
27(1)
Опубликована: Май 21, 2025
Язык: Английский
Artificial Intelligence and Disease Signature Pathways: Driving Innovation to Elucidate Underlying Pathogenic Mechanisms
Current Neurovascular Research,
Год журнала:
2024,
Номер
21(3), С. 229 - 233
Опубликована: Июнь 24, 2024
Язык: Английский
The potency of Thymus vulgaris seed extract in alleviating obesity complications and iron overload in obese rats
Journal of Functional Foods,
Год журнала:
2024,
Номер
121, С. 106416 - 106416
Опубликована: Авг. 23, 2024
Язык: Английский
Synaptophysin and GSK-3beta activity in the prefrontal cortex may underlie the effects of REM sleep deprivation and lithium on behavioral functions and memory performance in male rats
Maryam Gholami-Zanjanbar,
Faezeh Soleimanian,
Niloufar Reyhani
и другие.
Pharmacology Biochemistry and Behavior,
Год журнала:
2024,
Номер
unknown, С. 173894 - 173894
Опубликована: Окт. 1, 2024
Язык: Английский
Cardiovascular and nonalcoholic fatty liver disease: Sharing common ground through SIRT1 pathways
World Journal of Cardiology,
Год журнала:
2024,
Номер
16(11), С. 632 - 643
Опубликована: Окт. 30, 2024
As
a
non-communicable
disease,
cardiovascular
disorders
have
become
the
leading
cause
of
death
for
men
and
women.
Of
additional
concern
is
that
disease
linked
to
chronic
comorbidity
include
nonalcoholic
fatty
liver
(NAFLD).
NAFLD,
also
termed
metabolic-dysfunction-associated
steatotic
greatest
throughout
world,
increasing
in
prevalence
concurrently
with
diabetes
mellitus
(DM),
can
progress
steatohepatitis
leads
cirrhosis
fibrosis.
Individuals
metabolic
disorders,
such
as
DM,
are
more
than
two
times
likely
experience
cardiac
stroke,
includes
NAFLD
when
compared
individuals
without
disorders.
Interestingly,
share
common
underlying
cellular
mechanism
pathology,
namely
silent
mating
type
information
regulation
2
homolog
1
(SIRT1;
Язык: Английский