Integrated network pharmacological analysis and multi-omics techniques to reveal the mechanism of polydatin in the treatment of silicosis via gut-lung axis
European Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
unknown, С. 107030 - 107030
Опубликована: Фев. 1, 2025
Silicosis
is
a
pulmonary
disease
characterized
by
inflammation
and
progressive
fibrosis.
Previous
studies
have
shown
that
polydatin
(PD)
has
potential
biological
activity
in
key
signaling
pathways
regulating
apoptosis.
To
investigate
the
effect
of
PD
on
rats
with
silicosis,
this
study
used
network
pharmacology
molecular
docking
methods
to
determine
target
treatment
for
silicosis.
The
therapeutic
silicosis
was
confirmed
measuring
lung
injury
score,
hydroxyproline
content,
mRNA
expression
levels
targets.
In
addition,
metagenomic
sequencing
gas
chromatography-mass
spectrometry
were
gut
microbiota
composition
targeted
metabolomics
analysis,
respectively.
results
showed
could
inhibit
inflammation-related
indexes
apoptosis-related
at
protein
levels.
also
regulates
diversity
intestinal
flora
content
short-chain
fatty
acids.
conclusion,
current
data
suggest
protective
against
silica-induced
plays
role
acid
through
gut-lung
axis.
Язык: Английский
Tetrandrine induces cell cycle arrest in cutaneous melanoma cells by inhibiting IL-6/CDC42 signaling
Archives of Dermatological Research,
Год журнала:
2025,
Номер
317(1)
Опубликована: Фев. 20, 2025
Язык: Английский
Tetrandrine augments melanoma cell immunogenicity via dual inhibition of autophagic flux and proteasomal activity enhancing MHC-I presentation
Lina He,
Yu-jiao Liu,
Junbo Jiang
и другие.
Acta Pharmacologica Sinica,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Abstract
MHC-I-mediated
antigen
presentation
is
pivotal
in
antitumor
immunity,
enabling
the
recognition
and
destruction
of
tumor
cells
by
CD8
+
T
cells.
Both
proteasome
autophagy
serve
as
essential
cellular
degradation
mechanisms
that
regulate
stability
functionality
MHC-I
molecules.
In
melanoma,
modulating
pathways
affect
can
profoundly
influence
therapeutic
outcomes
immunotherapy.
Our
initial
effort
this
study
was
a
screening
process
to
identify
natural
compounds
capable
amplifying
surface
expression
on
B16
melanoma
Utilizing
flow
cytometry
with
fluorescently
tagged
antibodies,
we
identified
tetrandrine
(Tet),
bisbenzylisoquinoline
alkaloid
derived
from
root
Stephania
tetrandra
,
potent
enhancer
We
demonstrate
(2.5,
5,
7.5
μM)
dose-dependently
upregulates
both
total
protein
levels
or
A375
simultaneously
inhibiting
proteasomal
activity,
two
key
involved
degradation.
This
dual
inhibition
stabilizes
molecules,
leading
enhanced
improved
co-culture
systems,
treatment
increased
cell
activation
cytotoxicity
against
cells,
evidenced
elevated
IFN-γ
secretion
apoptosis.
Administration
(50
mg·kg
-1
·d
i.g.,
for
15
days)
significantly
suppressed
growth
mouse
models
accompanied
infiltration
within
microenvironment.
Notably,
synergized
anti-PD-1
immune
checkpoint
therapy,
compared
either
alone.
revealed
(7.5
blocked
lysosomal
calcium
efflux
channel
TPC2,
disrupting
homeostasis,
thus
impairing
acidification
thereby
stabilizing
molecules
promoting
presentation.
These
results
highlight
tetrandrine’s
unique
mechanism
action
enhancing
through
autophagic
flux
underscores
potential
novel
immunomodulatory
agent
boost
cell-mediated
eradication
enhance
efficacy
therapies.
Язык: Английский
Neuroinflammation and energy metabolism: a dual perspective on ischemic stroke
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 10, 2025
Ischemic
stroke
is
a
prevalent
form
of
cerebrovascular
accident,
with
its
pathogenesis
involving
the
intricate
interplay
between
neuroinflammation
and
energy
metabolism.
Cerebral
ischemia
disrupts
oxygen
supply,
triggering
metabolic
dysregulation
activating
neuroinflammatory
responses,
ultimately
resulting
in
cellular
damage.
This
review
provides
an
exhaustive
analysis
complex
mechanisms
ischemic
stroke,
particular
focus
on
interaction
The
interruption
supply
due
to
cerebral
initiates
activates
including
release
inflammatory
cytokines
activation
immune
cells,
contributing
damage
further
disturbances.
Studies
indicate
that
metabolism
significantly
impairs
neural
cell
function
interacts
neuroinflammation,
exacerbating
brain
injury.
Therapeutic
strategies
primarily
concentrate
modulating
suppressing
emphasizing
importance
in-depth
research
into
their
provide
theoretical
foundation
for
new
treatment
stroke.
Future
should
how
balance
anti-inflammatory
regulation
minimize
promote
recovery.
Язык: Английский
Tetrandrine and adriamycin reverse multidrug resistance by regulating NLRP3/Caspase-1/GSDMD signaling in human breast cancer cells
European Journal of Pharmacology,
Год журнала:
2025,
Номер
998, С. 177635 - 177635
Опубликована: Апрель 17, 2025
Язык: Английский
Tetrandrine ameliorated atherosclerosis in vitamin D3/high cholesterol diet-challenged rats via modulation of miR-34a and Wnt5a/Ror2/ABCA1/NF-kB trajectory
Yasmin El Zouka,
Eman Sheta,
Mona Abdelrazek Salama
и другие.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Сен. 12, 2024
Язык: Английский
Microgel-Encapsulated Tetrandrine Nanoparticles Promote Spinal Cord Repair by Sustaining Neuroinflammation Inhibition
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
13(2), С. 683 - 694
Опубликована: Ноя. 22, 2024
By
embedding
Tet
nanoparticles
in
microgels,
we
developed
a
dual-drug
system
for
controlled
drug
delivery
to
restrain
neuroinflammation
SCI.
Язык: Английский
Advances in nano‐preparations for improving tetrandrine solubility and bioavailability
Archiv der Pharmazie,
Год журнала:
2024,
Номер
357(10)
Опубликована: Июнь 20, 2024
Abstract
Tetrandrine
(TET)
is
a
natural
bis‐benzylisoquinoline
alkaloid
isolated
from
Stephania
species
with
wide
range
of
biological
and
pharmacologic
activities;
it
mainly
serves
as
an
anti‐inflammatory
agent
or
antitumor
adjuvant
in
clinical
applications.
However,
limitations
such
prominent
hydrophobicity,
severe
off‐target
toxicity,
low
absorption
result
suboptimal
therapeutic
outcomes
preventing
its
widespread
adoption.
Nanoparticles
have
proven
to
be
efficient
devices
for
targeted
drug
delivery
since
drug‐carrying
nanoparticles
can
passively
transported
the
tumor
site
by
enhanced
permeability
retention
(EPR)
effects,
thus
securing
niche
cancer
therapies.
Great
progress
has
been
made
nanocarrier
construction
TET
due
their
outstanding
advantages
increased
water‐solubility,
improved
biodistribution
blood
circulation,
reduced
irritation,
combinational
therapy.
Herein,
we
systematically
reviewed
latest
advancements
TET‐loaded
respective
features
expectation
providing
perspective
guidelines
future
research
potential
applications
TET.
Язык: Английский
Acoustic resonance technology and quality by design approach facilitate the development of the robust tetrandrine nano-delivery system
European Journal of Pharmaceutics and Biopharmaceutics,
Год журнала:
2024,
Номер
unknown, С. 114522 - 114522
Опубликована: Окт. 1, 2024
Язык: Английский
Insights on exploring the therapeutic potential and structural modification of Tetrandrine
Future Medicinal Chemistry,
Год журнала:
2024,
Номер
16(24), С. 2687 - 2700
Опубликована: Ноя. 28, 2024
Tetrandrine
(Tet),
a
bisbenzylisoquinoline
alkaloid
from
Stephania
tetrandra,
is
noted
for
its
diverse
pharmacological
effects
but
faces
limitations
in
clinical
use
due
to
toxicity,
poor
solubility,
and
low
bioavailability.
Researchers
are
working
address
these
issues
by
developing
Tet
derivatives
with
greater
therapeutic
potential
through
structural
modification.
Generally,
key
modifications
include:
1)
introducing
an
aromatic
heterocycle
or
hydrophobic
alkyne
unit
at
the
C-5
position
can
enhance
antitumor
activity;
2)
adding
amide,
sulfonamide,
electron-withdrawing
group
C-14
3)
changing
structure
quaternary
ammonium
salt
alter
solubility
greatly
boost
antibacterial
4)
modification
of
C-12-methoxybenzyl
motif
metabolic
stability
thus
change
activity
analogs;
5)
simplification
may
result
identification
anticancer
lead
compounds
novel
mechanisms
action.
This
review
systematically
summarizes
strategies
evaluates
biological
activities
derivatives,
aiming
guide
further
optimization
facilitate
discovery
analogs
improved
efficacy.
The
future
direction
possibility
also
considered.
Язык: Английский