Coumarins: Chemical Synthesis, Properties and Applications
Düzce Üniversitesi Bilim ve Teknoloji Dergisi,
Год журнала:
2025,
Номер
13(1), С. 131 - 170
Опубликована: Янв. 30, 2025
Coumarins
are
compounds
characterized
by
a
benzopyrone
structure
resulting
from
the
condensation
of
pyrone
and
benzene
ring.
They
commonly
found
as
secondary
metabolites
in
various
plants,
microorganisms,
sponges.
These
play
crucial
role
defence
mechanisms,
extensive
research
has
revealed
numerous
biological
activities
associated
with
these
compounds.
Coumarin
its
derivatives
show
significant
potential
candidates
for
new
drugs
due
to
their
exceptional
biocompatibility
wide
range
activities,
including
antimicrobial,
anticancer,
antimitotic,
antioxidant,
anti-inflammatory,
anticoagulant
properties.
Beyond
medicinal
applications,
simple
versatile
scaffold
structures
coumarins
have
use
fields
such
food
production,
agriculture,
cosmetics,
textiles.
This
review
covers
classification
coumarin
derivatives,
well
chemical
synthesis
methods.
Furthermore,
it
delves
into
properties,
diverse
application
areas
coumarins.
Язык: Английский
Withania somnifera (Ashwagandha) Improves Spatial Memory, Anxiety and Depressive-like Behavior in the 5xFAD Mouse Model of Alzheimer’s Disease
Antioxidants,
Год журнала:
2024,
Номер
13(10), С. 1164 - 1164
Опубликована: Сен. 25, 2024
(WS),
also
known
as
ashwagandha,
is
a
popular
botanical
supplement
used
to
treat
various
conditions
including
memory
loss,
anxiety
and
depression.
Previous
studies
from
our
group
showed
an
aqueous
extract
of
WS
root
(WSAq)
enhances
cognition
alleviates
markers
for
depression
in
Язык: Английский
Effect of Withania somnifera on Expression of Selected Genes in Hippocampus of Male Wistar Rats Subjected to Chronic Unpredictable Mild Stress
International Journal of Applied and Basic Medical Research,
Год журнала:
2025,
Номер
15(1), С. 25 - 31
Опубликована: Янв. 1, 2025
Depression
affects
millions
globally,
with
existing
treatments
having
many
side
effects.
Withania
somnifera
(WS)
shows
potential
as
an
antidepressant
and
neuroprotective
agent,
possibly
by
influencing
brain-derived
neurotrophic
factor
(BDNF)-related
pathways.
This
study
evaluated
the
effect
of
WS
alone
in
combination
fluoxetine
on
neuritin,
NARP,
BDNF
Exon-III
gene
expression
hippocampus
male
Wistar
rats
subjected
to
chronic
unpredictable
mild
stress
(CUMS).
Thirty
were
divided
into
five
groups
(n
=
6
each):
normal
group
(NG),
disease
control
(DC),
standard
treatment
(ST),
WS,
(FW).
was
induced
using
CUMS,
except
NG.
The
sucrose
preference
test
confirmed
depression
at
end
3rd
week
assessed
effects
7th
week.
Gene
analyzed
through
real-time
PCR
After
7
weeks,
ST,
FW
showed
a
significant
increase
compared
DC
group.
ST
upregulation
all
three
genes
selected
present
study.
Comparison
between
NG
no
difference
expression.
highlights
demonstrating
its
BDNF-associated
Fluoxetine
combined
demonstrated
additive
which
proves
adjuvant
role
depression.
Further
studies
involving
human
subjects
are
essential
validate
fluoxetine.
Язык: Английский
Exploring Withanolides from Withania somnifera: A Promising Avenue for Alzheimer’s Disease Treatment
Current Pharmacology Reports,
Год журнала:
2025,
Номер
11(1)
Опубликована: Фев. 7, 2025
Язык: Английский
Maral Root Extract and Its Main Constituent 20-Hydroxyecdysone Enhance Stress Resilience in Caenorhabditis elegans
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3739 - 3739
Опубликована: Апрель 15, 2025
As
human
life
expectancy
continues
to
rise,
managing
age-related
diseases
and
preserving
health
in
later
years
remain
significant
challenges.
Consequently,
there
is
a
growing
demand
for
strategies
that
enhance
both
the
quality
duration
of
life.
Interventions
promote
longevity,
particularly
those
derived
from
natural
sources,
are
popular
their
potential
address
concerns.
Adaptogens—herbs,
roots,
mushrooms—are
valued
food
science
nutrition
ability
resilience
overall
well-being.
Among
these,
Rhaponticum
carthamoides
(Willd.)
Iljin,
known
as
maral
root
(Russian
leuzea),
holds
prominent
place
Siberian
traditional
medicine.
The
extract,
abundant
bioactive
compounds
such
flavonoids
phytoecdysteroids,
reputed
reducing
fatigue,
boosting
strength,
offering
immunomodulatory
benefits.
However,
effects
plant
extract
on
lifespan
decline
remains
poorly
studied.
This
study
investigates
effect
phytoecdysteroids—ecdysterone,
ponasterone,
turkesterone—on
aging
using
Caenorhabditis
elegans
model
organism.
A
sensitive
liquid
chromatography
method
with
photodiode
array
detection
was
developed
validated
quantify
phytoecdysteroids
extract.
Behavioural
stress-response
assays
revealed
not
only
extends
but
also
significantly
enhanced
healthspan,
stress
resilience,
fitness
nematodes.
Additionally,
treatment
ecdysterone,
most
compound
improved
healthspan
by
enhancing
response.
These
findings
underscore
adaptogen
mitigate
decline,
providing
valuable
insights
into
longevity
interventions.
Язык: Английский