Herbal and Dietary Supplements as Adjunctive Treatment for Mild SARS-CoV-2 Infection in Italy
Nutrients,
Год журнала:
2025,
Номер
17(2), С. 230 - 230
Опубликована: Янв. 9, 2025
During
the
COVID-19
pandemic,
several
observational
studies
proved
a
certain
efficacy
of
nutraceuticals,
herbal
products,
and
other
dietary
supplements
as
adjuvant
therapies
used
alongside
antiviral
drugs.
Although
their
use
has
not
been
widespread
in
Italy,
according
to
preliminary
evidence,
many
with
demonstrated
immunomodulatory
effects,
such
vitamins
C
D,
medicines
essential
oils,
might
relieve
respiratory
symptoms
COVID-19,
since
SARS-CoV-2
can
activate
inflammasome-mediated
inflammatory
signaling
pathways.
Other
have
shown
that
treatments,
Echinacea
purpurea
ginseng,
help
alleviate
reduce
serum
levels
cytokines,
which
are
typically
overexpressed
both
adult
pediatric
patients.
Further,
D
attenuate
immune
response
thanks
cytokine
suppression
ability
known
antimicrobial
activity
potential
modulate
T
helper
cell
response.
The
strong
triggered
by
infection
is
responsible
for
severity
disease.
Preliminary
data
also
L-arginine,
an
endothelial-derived
relaxing
factor,
able
endothelial
damage,
appears
be
one
main
targets
this
systemic
Finally,
some
oils
isolated
compounds,
eucalyptol,
may
helpful
reducing
although
others,
menthol,
recommended,
it
lead
undervaluation
clinical
status
patient.
In
narrative
review,
despite
lack
evidence
field,
we
aimed
give
overview
current
available
literature
(mainly
cross-sectional
studies)
regarding
products
treatment
mild
disease
from
infection.
Obviously,
do
constitute
standardized
disease,
but
they
could
represent
adjunctive
useful
when
together
antivirals.
Язык: Английский
Vitamin D supplementation for managing COVID-19 in patients with vitamin D deficiency: a systematic review and meta-analysis of randomised controlled trials
BMJ Open,
Год журнала:
2025,
Номер
15(3), С. e091903 - e091903
Опубликована: Март 1, 2025
Objectives
Vitamin
D
deficiency
is
prevalent
among
the
population.
Previous
studies
have
shown
that
vitamin
supplementation
might
be
useful
for
treating
COVID-19
infection.
Therefore,
we
performed
a
meta-analysis
to
explore
efficacy
in
patients
with
deficiency.
Design
Systematic
review
and
Data
sources
PubMed,
Cochrane
Library,
Embase
Web
of
Science.
Eligibility
criteria
Randomised
controlled
trials
exploring
extraction
synthesis
Two
independent
reviewers
employed
standardised
methods
search,
screen
code
included
studies.
The
primary
outcomes
mortality
during
follow-up,
28-day
mortality,
need
mechanical
ventilation
intensive
care
unit
(ICU).
secondary
outcome
length
stay
hospital
ICU.
risk
bias
was
assessed
using
Risk
Bias
2
tool.
Depending
on
level
heterogeneity,
either
random-effects
model
or
fixed-effects
applied.
findings
were
summarised
Grading
Recommendations
Assessment,
Development
Evaluation
(GRADE)
evidence
profiles
synthesised
qualitatively.
Results
A
total
nine
studies,
comprising
870
participants,
analysis.
pooled
results
indicated
associated
lower
(risk
ratio
0.76;
95%
CI
0.60
0.97).
However,
this
apparent
benefit
not
robust
when
examined
through
leave-one-out
method
trial
sequential
Regarding
other
outcomes,
there
no
statistically
significant
difference
between
terms
ICU
admission.
0.41
day
shorter
(mean
−0.41;
−1.09
0.28)
0.07
−0.07;
−0.61
0.46)
compared
supplementation;
however,
neither
significant.
Conclusion
Based
low
moderate
quality,
reduced
rate
follow-up
it
did
improve
nor
reduce
admission,
hospital.
PROSPERO
registration
number
CRD42024573791.
Язык: Английский
The Effect of Vitamin D Supplementation Post COVID-19 Infection and Related Outcomes: A Systematic Review and Meta-Analysis
Nutrients,
Год журнала:
2024,
Номер
16(22), С. 3794 - 3794
Опубликована: Ноя. 5, 2024
Vitamin
D's
role
in
COVID-19
management
remains
controversial.
This
meta-analysis
aimed
to
evaluate
the
efficacy
of
vitamin
D
supplementation
patients
with
SARS-CoV-2
infection,
focusing
on
mortality,
intensive
care
unit
(ICU)
admissions,
intubation
rates,
and
hospital
length
stay
(LOS).
Язык: Английский
The Challenge of Misleading Information: Does the Interaction between Zinc and Vitamin D Influence the Immune Response against SARS-CoV-2 in the Elderly Population?
Life,
Год журнала:
2024,
Номер
14(10), С. 1277 - 1277
Опубликована: Окт. 8, 2024
Immunization
is
a
challenge
for
the
elderly
population
and
can
leave
this
group
more
vulnerable
to
opportunistic
pathogens
such
as
SARS-CoV-2.
Due
situation,
while
vaccines
were
in
development
phase,
hypotheses
raised
about
role
of
vitamins
minerals
immunization.
In
Brazil,
there
was
controversy
regarding
well-known
COVID-19
Kit,
standardized
prescription
positive
cases
that
contained
zinc,
vitamin
D,
anti-parasitic
drugs.
There
great
scientific
circles,
since
brought
major
health
professionals
public
authorities:
misleading
information.
study,
we
evaluated
D
zinc
production
anti-SARS-CoV-2
neutralizing
antibodies
(NAbs)
residents
nursing
home
northeastern
Brazil.
Serum
levels
NAbs
assessed,
along
with
two
phases.
The
first
(T1)
August
2022
26
people,
second
(T2)
March
2023
21,
due
death
five
participants.
Overall,
observed
satisfactory
no
participants
showing
deficiency
either
test,
only
having
negative
result
at
T1
three
T2.
However,
drop
average
number
observed,
especially
women
(T1
=
89
±
19
vs.
T2
57
44),
highlighting
importance
monitoring
immunological
parameter
studied.
Based
on
results,
suggest
synergism
between
micronutrients
studied
(
Язык: Английский