The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progression

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Март 27, 2025

Alzheimer’s disease (AD) is a widespread neurodegenerative disorder and one of the major challenges for public health. Despite extensive research, role microglia in AD remains complex dual. The aim this review to summarize most recent advances research regarding dual concerning both immunomodulation pathological progression by considering mechanisms activation microglia, effects on Aβ clearance, tau pathology, impacts due genetic variations microglial functions. Among these findings are status M1 M2 phenotypes, crucial that variants like TREM2 have modulating response microglia. This describes how modulation signaling pathway might be exploited therapeutically treatment underlines relevance personalized medicine approach.

Язык: Английский

Exploring Retinal Neurodegeneration in Alzheimer’s Disease: A Molecular and Cellular Perspective

Neurotoxicity Research, Год журнала: 2025, Номер 43(2)

Опубликована: Апрель 1, 2025

Язык: Английский

Unraveling the Immune Puzzle: Role of Immunomodulation in Alzheimer’s Disease

Journal of Neuroimmune Pharmacology, Год журнала: 2025, Номер 20(1)

Опубликована: Апрель 29, 2025

Язык: Английский