Osteoprotective Activity of Sambucus javanica Reinw Ex Blume subsp. javanica Leaf Extracts by Suppressing ROS Production
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 252 - 252
Опубликована: Фев. 21, 2025
Sambucus
javanica
subsp.
(SJ)
has
been
used
in
traditional
medicine
the
northern
region
of
Thailand
for
healing
bone
fractures;
however,
studies
on
how
this
plant
stimulates
formation
are
still
scarce.
The
present
study
aimed
to
investigate
potential
crude
extracts
and
fractions
obtained
from
SJ
leaves
osteoporotic
protection.
All
samples
were
investigated
murine
preosteoblast
MC3T3-E1
cells
resorption
biomarkers,
namely
alkaline
phosphatase
(ALP),
osteocalcin
(OC),
osteoprotegerin
(OPG),
receptor
activator
nuclear
factor-κB
ligand
(RANKL),
OPG/RANKL
ratio.
Additionally,
calcium
deposits
determined
using
alizarin
red
S
staining
technique.
results
indicated
that
water
ethanol
contained
gallic
acid,
rutin,
chlorogenic
acid
as
major
compounds.
stimulated
osteoblastic
cell
differentiation
enhanced
osteoprotective
activity,
measured
by
a
significant
increase
ALP
OC,
OPG,
ratio,
degree
calcification.
they
exhibited
negative
impact
significantly
reducing
RANKL
reactive
oxygen
species
(ROS)
production.
Therefore,
our
findings
add
novel
evidence
indicating
extraction
could
be
further
utilized
natural
active
pharmaceutical
ingredient
(NAPI)
development
health
products.
Язык: Английский
Dual Targeting of FSP1 and xCT: Potential Mechanism of Anthocyanins in Alleviating Neuronal Ferroptosis in Vascular Dementia
Phytomedicine,
Год журнала:
2025,
Номер
142, С. 156608 - 156608
Опубликована: Март 4, 2025
Язык: Английский
Nutritional and Chemical Characterization of Red and Purple Potatoes Peels: A Polyphenol-Rich By-Product
Foods,
Год журнала:
2025,
Номер
14(10), С. 1740 - 1740
Опубликована: Май 14, 2025
Potato
peel
represents
a
major
by-product
of
the
potato-processing
industry
and
promising
source
bioactive
compounds
with
potential
health
benefits.
This
study
investigates
biochemical
nutritional
composition
peels
from
five
purple
two
red
potato
cultivars,
particular
attention
to
their
phytochemical
profiles
antioxidant
properties.
Total
phenolic
content,
carbohydrates,
proteins,
lipids
were
quantified
using
UV-visible
spectrophotometry.
The
was
further
characterized
via
High-Performance
Liquid
Chromatography
coupled
Diode-Array
Detector
(HPLC-DAD).
Antioxidant
radical-scavenging
capacities
extracts
assessed
through
Ferric
Reducing
Power
(FRAP)
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
assays.
Significant
variability
observed
across
cultivars
for
all
measured
parameters.
While
samples
rich
in
carbohydrates
they
shared
common
profile
dominated
by
chlorogenic
acid
its
derivatives,
as
well
caffeic
acid.
Anthocyanin
composition,
however,
highly
cultivar-specific.
Notably,
demonstrated
strong
antiradical
activities,
agreement
high
total
content.
These
findings
highlight
valuable
sources
functional
ingredients
food
nutraceutical
applications.
Язык: Английский