The expression of insulin signaling and N-methyl-D-aspartate receptor genes in areas of gray matter atrophy is associated with cognitive function in type 2 diabetes.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Type 2 diabetes (T2DM) is associated with brain abnormalities and cognitive dysfunction, including increased risk for Alzheimer's disease. However, the mechanisms of T2DM-related dementia remain poorly understood. We obtained retrospective data from Mayo Clinic Study Aging 271 individuals T2DM 542 demographically matched non-diabetic controls (age 51-89, 62% male). identified regions significant gray matter atrophy in group then determined which genes were significantly expressed these using imaging transcriptomics. selected 15 candidate involved insulin signaling, lipid metabolism, amyloid processing, N-methyl-D-aspartate-mediated neurotransmission, calcium signaling. The demonstrated default mode, frontal-parietal, sensorimotor networks (p < 0.05 cluster threshold corrected false discovery rate, FDR). IRS1, AKT1, PPARG, PRKAG2 , GRIN2B same (R > 0.10, p 0.03, FDR corrected). Bayesian network analysis indicated directional paths among all 5 as well Clinical Dementia Rating score. Directional altered (Structural Hamming Distance = 12, 0.004), PPARG expression becoming more important context pathophysiology. Alterations transcriptome patterns occurred absence deficit or accumulation, potentially representing an early biomarker dementia.

Язык: Английский

IGF-1 signaling pathway activation promotes axonal regeneration and repair: a mechanism study on catalpol-induced functional recovery after ischemic stroke

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119808 - 119808

Опубликована: Апрель 1, 2025

Язык: Английский