Progress in Retinal and Eye Research, Год журнала: 2024, Номер unknown, С. 101325 - 101325
Опубликована: Дек. 1, 2024
Язык: Английский
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 8, 2025
Abstract Fuchs Endothelial Corneal Dystrophy (FECD) is the most frequent indication for corneal transplantation, with Descemet membrane endothelial keratoplasty (DMEK), stripping automated (DSAEK), and penetrating (PK) being viable options. This retrospective study compared 10-year outcomes of these techniques in a large cohort 2956 first-time eyes treated FECD at high-volume transplant center Germany. While DMEK DSAEK provided faster visual recovery (median time to BSCVA ≥ 6/12 Snellen: 7.8 months, 12.4 PK 37.9 months; cumulative probability Snellen within 5 years: 93%, 83%, 63%), surprisingly exhibited superior long-term graft survival (92% vs. 75% 73% 10 years). cell density (ECD) decreased significantly after DSAEK, potentially contributing their lower (10-year ECD > 1000 cells/mm 2 probability: 3%, 8%, 18%). demonstrated lowest rejection rate (10% years 13% 19% DSAEK). These findings challenge perceived superiority highlight need further investigation into implications accelerated loss DSAEK.
Язык: Английский
Процитировано
1
Biomaterials Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Biomaterial-based strategies, including ECM coatings and functionalized polymers, enable efficient expansion of primary human corneal endothelial cells, addressing donor shortages advancing cell therapy for transplantation.
Язык: Английский
Процитировано
0
Highlights of ophthalmology., Год журнала: 2025, Номер 53(1S), С. 14 - 20
Опубликована: Фев. 13, 2025
Процитировано
0
Highlights of ophthalmology., Год журнала: 2025, Номер 53(1E), С. 14 - 20
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
0
Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(3), С. 135 - 135
Опубликована: Фев. 20, 2025
Fuchs’ endothelial corneal dystrophy (FECD) is a progressive eye disease characterized by accelerated loss of cells and the development focal excrescence (guttae) on Descemet’s membrane, resulting in cornea opacity vision deterioration. The FECD assumed to be due interplay between genetic environmental factor risks, causing abnormal extracellular-matrix organization, increased oxidative stress, apoptosis unfolded protein response. However, molecular knowledge limited. genome-wide platforms bioinformatics approaches has enabled us identify numerous loci that are associated with FECD. In this review, we gathered studies (n = 31) sorted them according genomics 9), epigenomics 3), transcriptomics 15), proteomics 3) metabolomics 1) levels characterize progress understanding We also extracted validated differentially expressed/spliced genes proteins identified through comparisons case control groups. addition, highlighted from each omics layer were combined comparison similar study groups original for downstream gene-set enrichment analysis, which provided most significant biological pathways related organization. future, multiomics needed increase sample size statistical power strong candidate functional animal models cell lines better
Язык: Английский
Процитировано
0
Cornea, Год журнала: 2025, Номер unknown
Опубликована: Март 7, 2025
Dorado Cortez, Oliver MD; Gain, Philippe MD, PhD; Thuret, Gilles PhD Author Information
Язык: Английский
Процитировано
0
International Ophthalmology, Год журнала: 2025, Номер 45(1)
Опубликована: Март 30, 2025
Язык: Английский
Процитировано
0
Nano Today, Год журнала: 2025, Номер 63, С. 102740 - 102740
Опубликована: Апрель 4, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3343 - 3343
Опубликована: Апрель 3, 2025
Fuchs' endothelial corneal dystrophy (FECD) is a genetically complex eye disease associated with multiple genes. A recent systematic review has raised concerns about the causal role of variants in LOXHD1 and AGBL1 genes development FECD. Conflicting data have been reported on expression endothelium. Furthermore, only partial segregation was observed familial cases. An analysis published datasets conducted to examine normal FECD-affected endothelia progenitor cells. Neither nor were expressed or FECD In-house cohorts screened for carriers previously variants. Carriers their first-degree relatives invited an ophthalmological examination reassess relationship these phenotype. Three (one carrier rs200242497 two rs192376005) (rs181958589 rs185919705) recruited. None over 50 years exhibited phenotypic signs via ophthalmic examination. The found not confirmed. Taken together, our findings do support
Язык: Английский
Процитировано
0
Bioengineering, Год журнала: 2024, Номер 11(3), С. 271 - 271
Опубликована: Март 11, 2024
Fuchs endothelial corneal dystrophy (FECD) is a complex genetic disorder characterized by the slow and progressive degeneration of cells. Thus, it may result in decompensation irreversible edema. Moreover, FECD associated with alterations all layers, such as thickening Descemet membrane, stromal scarring, subepithelial fibrosis, formation epithelial bullae. Hence, anterior segment imaging devices that enable precise measurement functional anatomical changes cornea are essential for management FECD. In this review, authors will introduce studies on application various modalities, optical coherence tomography, Scheimpflug specular microscopy, vitro confocal retroillumination photography, diagnosis monitoring discuss results these studies. The novel technologies, including image processing technology artificial intelligence, expected to further enhance accuracy, precision, speed technologies also be discussed.
Язык: Английский
Процитировано
0