Chronic Endometritis in Infertile Women: Impact of Untreated Disease, Plasma Cell Count and Antibiotic Therapy on IVF Outcome—A Systematic Review and Meta-Analysis

Diagnostics, Год журнала: 2022, Номер 12(9), С. 2250 - 2250

Опубликована: Сен. 18, 2022

This systematic review and meta-analysis aims to evaluate the impact of chronic endometritis (CE) its therapy on in vitro fertilization (IVF) outcome. Additionally, we aim investigate whether various degrees CE severity may exert a different effect IVF Ongoing-pregnancy rate/live-birth-rate (OPR/LBR), clinical-pregnancy rate (CPR), miscarriage (MR) were calculated. A total number 4145 patients (from ten studies) included. Women with had lower OPR/LBR (OR 1.97, p = 0.02) CPR 2.28, 0.002) compared those without CE. cure increased 5.33, < 0.0001) 3.64, 0.0001). outcome was comparable between women cured (OPR/LBR, MR: ns). severe 0.43, 0.003) 0.40, 0.0007) mild Mild showed no influence as Based this data analysis, significantly reduces undergoing IVF. Importantly, resolution after antibiotic improves outcome, leading similar unaffected patients. The negative effects be restricted disease, whereas have success.

Язык: Английский

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Challenges in Clinical Diagnosis and Management of Chronic Endometritis

Diagnostics, Год журнала: 2022, Номер 12(11), С. 2711 - 2711

Опубликована: Ноя. 5, 2022

Chronic endometritis (CE) is a local mucosal infectious and inflammatory disorder characterized by unusual filtration of CD138(+) endometrial stromal plasmacytes. CE attracting attention due to its potential association with infertility unknown etiology, repeated implantation failure, recurrent pregnancy loss, several maternal/neonatal complications. Due the variance in study design among researchers, universal diagnostic criteria remain be established for clinical diagnosis management CE. This review article aims summarize current knowledge provide insights into unsolved questions on establish guidelines disease from viewpoint human reproduction.

Язык: Английский

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The Role of Plasma Cells as a Marker of Chronic Endometritis: A Systematic Review and Meta-Analysis

Biomedicines, Год журнала: 2023, Номер 11(6), С. 1714 - 1714

Опубликована: Июнь 15, 2023

Chronic endometritis (CE) is the persistent inflammation of endometrial lining associated with infertility and various forms reproductive failures. The diagnosis CE based on histological evidence stromal plasma cells; however, standardized methods to assess cells are still lacking. In present paper, we aimed determine most appropriate cell threshold diagnose pregnancy outcomes. Three electronic databases were searched from their inception February 2022 for all studies comparing outcomes between patients without CE. relative risk (RR) pregnancy, miscarriage, and/or live birth rates calculated pooled adopted. A p-value < 0.05 was considered significant. Nine adopting different thresholds (1 50 cells/10 HPF) included. meta-analysis, only found a significant association miscarriage rate count ≥ 5/10 HPF (RR = 2.4; p 0.007). Among not suitable showed an worsened when high (10 50/10 conclusion, our study suggests that presence at low levels (<5/10 may predict Based these findings, ≥5 be more

Язык: Английский

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Isthmocele, not cesarean section per se, reduces in vitro fertilization success: a systematic review and meta-analysis of over 10,000 embryo transfer cycles

Fertility and Sterility, Год журнала: 2023, Номер 121(2), С. 299 - 313

Опубликована: Ноя. 10, 2023

ImportancePrevious reviews have shown that a history of cesarean section (CS) is associated with worse in vitro fertilization (IVF) prognosis. To date, whether the decline IVF chances success should be attributed to CS procedure itself or presence isthmocele remains clarified.ObjectiveTo summarize available evidence regarding impact on outcomes.Data SourcesElectronic databases and clinical registers were searched until May 30, 2023.Study Selection SynthesisObservational studies included if they assessed effect outcomes. Comparators women without previous vaginal delivery. Study quality was using modified Newcastle-Ottawa Scale.Main OutcomesThe primary outcome live birth rate (LBR). The measures expressed as adjusted odds ratios (aORs) unadjusted (uORs) 95% confidence intervals (95% CIs). body Grading Recommendations Assessment, Development Evaluation working group methodology.ResultsEight (n = 10,873 patients) analysis. Women showed lower LBR than both (aOR, 0.62; CI, 0.53–0.72) those delivery 0.55; 0.42–0.71). LBRs similar 0.74; 0.47–1.15). Subgroup analysis suggested negative intracavitary fluid (ICF) (uOR, 0.36; 0.18–0.75), whereas ICF 0.94; 0.61–1.45).Conclusion RelevanceWe found moderate (Grading grade 3/4) supporting isthmocele, but not per se, undergoing IVF. adverse outcomes appears worsened by accumulation before embryo transfer.Clinical Trial Registration NumberCRD42023418266. Previous clarified. Electronic 2023. Observational Scale. methodology. Eight 0.61–1.45). We transfer.

Язык: Английский

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Chronic endometritis increases the recurrence of endometrial polyps in premenopausal women after hysteroscopic polypectomy

BMC Women s Health, Год журнала: 2023, Номер 23(1)

Опубликована: Фев. 25, 2023

Abstract Background The reported recurrence rate of endometrial polyps (EPs) after hysteroscopic polypectomy varied widely, and the factors influencing EPs are still controversial. Furthermore, known definite independent risk almost unchangeable, such as number previous history. aim this study was to evaluate impact chronic endometritis (CE) on in premenopausal women who underwent polypectomy. Methods A retrospective conducted at a university-affiliated hospital. Premenopausal were enrolled, those with confounding for polyp excluded, including endometriosis total 233 enrolled study, 64 (27.5%) cases CE 169 (72.5%) without CE. diagnosed via immunohistochemical detection CD138 specimen. Comparison performed or each monitoring stage (i.e., 3, 6, 9 12 months) Results rates one year patients 26.6% (95% confidence interval [CI] 15.8–37.4%) 9.5% CI 5.0–14.0%), respectively, an overall 14.2% 9.7–18.7%). hazard ratio (HR) cohort versus 3.08 1.56–6.09) ( P = 0.001). Similarly, significantly higher than 6 months). multiple recurrence. HR compared 3.06, adjustment EPs. Conclusions harmful factor Thus, routine screening during needed. Frequent needed also contributed

Язык: Английский

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Uterus didelphys: the first case report on molecular profiling of endometrial tissue from both uterine cavities

Reproductive Biology and Endocrinology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 4, 2025

Язык: Английский

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Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion

Microorganisms, Год журнала: 2025, Номер 13(1), С. 197 - 197

Опубликована: Янв. 17, 2025

Chronic endometritis (CE) is a persistent inflammatory condition of the endometrium characterized by abnormal infiltration plasma cells into endometrial stroma. Frequently associated with repeated implantation failure, recurrent pregnancy loss, and infertility, CE significantly impacts women's health, contributing to conditions such as uterine bleeding endometriosis. Treatment typically involves antibiotic therapy; however, efficacy these treatments increasingly compromised rise antimicrobial resistance (AMR). This paper examines critical links between AMR CE, proposing strategies enhance clinical management optimize treatment outcomes.

Язык: Английский

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Precision Medicine for Chronic Endometritis: Computer-Aided Diagnosis Using Deep Learning Model

Diagnostics, Год журнала: 2023, Номер 13(5), С. 936 - 936

Опубликована: Март 1, 2023

Chronic endometritis (CE) is a localized mucosal infectious and inflammatory disorder marked by infiltration of CD138(+) endometrial stromal plasmacytes (ESPC). CE drawing interest in the field reproductive medicine because its association with female infertility unknown etiology, endometriosis, repeated implantation failure, recurrent pregnancy loss, multiple maternal/newborn complications. The diagnosis has long relied on somewhat painful biopsy histopathologic examinations combined immunohistochemistry for CD138 (IHC-CD138). With IHC-CD138 only, may be potentially over-diagnosed misidentification epithelial cells, which constitutively express CD138, as ESPCs. Fluid hysteroscopy emerging an alternative, less-invasive diagnostic tool that can visualize whole uterine cavity real-time enables detection several unique findings associated CE. biases hysteroscopic CE; however, are inter-observer intra-observer disagreements interpretation endoscopic findings. Additionally, due to variances study designs adopted criteria, there exists some dissociation among researchers. To address these questions, novel dual another plasmacyte marker myeloma oncogene 1 currently being tested. Furthermore, computer-aided using deep learning model developed more accurate These approaches have potential contribute reduction human errors biases, improvement performance CE, establishment unified criteria standardized clinical guidelines disease.

Язык: Английский

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In women with endometriosis, effective treatment of chronic endometritis with antibiotics lowers serum CA-125 levels

Fertility and Sterility, Год журнала: 2024, Номер 121(6), С. 1066 - 1068

Опубликована: Фев. 23, 2024

Язык: Английский

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Construction of deep learning-based convolutional neural network model for automatic detection of fluid hysteroscopic endometrial micropolyps in infertile women with chronic endometritis

European Journal of Obstetrics & Gynecology and Reproductive Biology, Год журнала: 2024, Номер 297, С. 249 - 253

Опубликована: Апрель 21, 2024

Язык: Английский

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