Pure and Doped Brushite Cements Loaded with Piroxicam for Prolonged and Constant Drug Release DOI Open Access
Marcella Bini, Giovanna Bruni, Michela Sturini

и другие.

Materials, Год журнала: 2025, Номер 18(5), С. 1065 - 1065

Опубликована: Фев. 27, 2025

The increase in life expectancy has led to a rise of musculoskeletal disorders. Calcium phosphate cements (CPCs), thanks some amazing features such as the ability harden vivo, bioactivity, and resorbability, are promising candidates treat these diseases, notwithstanding their poor mechanical properties. We aimed synthesise pure barium- or silicon-doped brushite-based CPCs loaded with piroxicam study effects substitution on physical-chemical pharmaceutical properties before after cement immersion buffer for different time periods. Our results demonstrated that became amorphous hardened cements. dopants did not change brushite structure its lamellar morphology, while both Ba Si additions improved initial Young's modulus compared cement, opposite trend was observed compressive strength. Both strength elastic decreased samples immersed solution non-immersed samples, stabilisation number days increased. After 7 days, whole drug amount released, slower constant kinetic Ba-doped Si-doped ones.

Язык: Английский

Pure and Doped Brushite Cements Loaded with Piroxicam for Prolonged and Constant Drug Release DOI Open Access
Marcella Bini, Giovanna Bruni, Michela Sturini

и другие.

Materials, Год журнала: 2025, Номер 18(5), С. 1065 - 1065

Опубликована: Фев. 27, 2025

The increase in life expectancy has led to a rise of musculoskeletal disorders. Calcium phosphate cements (CPCs), thanks some amazing features such as the ability harden vivo, bioactivity, and resorbability, are promising candidates treat these diseases, notwithstanding their poor mechanical properties. We aimed synthesise pure barium- or silicon-doped brushite-based CPCs loaded with piroxicam study effects substitution on physical-chemical pharmaceutical properties before after cement immersion buffer for different time periods. Our results demonstrated that became amorphous hardened cements. dopants did not change brushite structure its lamellar morphology, while both Ba Si additions improved initial Young's modulus compared cement, opposite trend was observed compressive strength. Both strength elastic decreased samples immersed solution non-immersed samples, stabilisation number days increased. After 7 days, whole drug amount released, slower constant kinetic Ba-doped Si-doped ones.

Язык: Английский

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