Is adding an Oral Antibiotic with the Topical Antibiotic-Steroid Useful in Treatment of Uncomplicated Acute Otitis Externa in Immunocompetent Patients? DOI Open Access
Ahmed Muhei Rasheed,

Shamil Abbood Hilal,

Azzam Muhsin Abbas

и другие.

Journal of Population Therapeutics and Clinical Pharmacology, Год журнала: 2022, Номер 29(2)

Опубликована: Янв. 1, 2022

Acute otitis externa (AOE) is a common disease encountered in otolaryngology practice, it mainly bacterial origin. AOE can cause severe otalgia and interrupt the daily activities; however, bed rest required about 20% of patients.To evaluate usefulness adding an oral antibiotic with topical steroid treatment uncomplicated which limited to ear canal immunocompetent patients.A prospective comparative clinical study was conducted department at Al-Jerrahat Teaching Hospital Private Clinic, Baghdad, Iraq, during period from April 2020 October 2021. A total 68 patients (39 females 29 males), diagnosed as cases canal, were included this study. The categorized into two groups. Patients group treated tobramycin 0.3%-dexamethasone 0.1% drops, while B received same plus Ciprofloxacin tablets 500 mg twice daily. followed up on day-to-day basis until complete resolution pain edema. severity assessed by visual analogue scale (VAS) scores, edema graded dividing imaginary horizontal vertical lines four quarters. post-treatment VAS scores grades both groups compared. Statistical analysis using t-test done calculate P-value order find if there significant difference regarding between B.During whole follow-up no (P-value more than 0.05).There benefit patients.

Язык: Английский

Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives DOI Open Access
Rubiya Khursheed, Kamal Dua, Sukriti Vishwas

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 150, С. 112951 - 112951

Опубликована: Апрель 18, 2022

The current advancements in nanotechnology are as an outcome of the development engineered nanoparticles. Various metallic nanoparticles have been extensively explored for various biomedical applications. They attract lot attention field due to their significant inert nature, and nanoscale structures, with size similar many biological molecules. Their intrinsic characteristics which include electronic, optical, physicochemical and, surface plasmon resonance, that can be changed by altering certain particle such size, shape, environment, aspect ratio, ease synthesis functionalization properties led numerous applications fields biomedicine. These targeted drug delivery, sensing, photothermal photodynamic therapy, imaging, well modulation two or three article also discusses about cancer imaging therapeutics. associated bottlenecks related clinical translation discussed.

Язык: Английский

Процитировано

176
Green synthesis of iron nanoparticles: Sources and multifarious biotechnological applications DOI
Vinod Kumar, Naveen Kumar Kaushik, Santosh Kumar Tiwari

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 127017 - 127017

Опубликована: Сен. 23, 2023

Язык: Английский

Процитировано

47
Significance of Capping Agents of Colloidal Nanoparticles from the Perspective of Drug and Gene Delivery, Bioimaging, and Biosensing: An Insight DOI Open Access
Rabia Javed, Anila Sajjad, Sania Naz

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(18), С. 10521 - 10521

Опубликована: Сен. 10, 2022

The over-growth and coagulation of nanoparticles is prevented using capping agents by the production stearic effect that plays a pivotal role in stabilizing interface. This strategy coating nanoparticles’ surface with an emerging trend assembling multipurpose beneficial for improving their physicochemical biological behavior. enhancement reactivity negligible toxicity outcome. In this review article, attempt has been made to introduce significance different preparation nanoparticles. Most importantly, we have highlighted recent progress, existing roadblocks, upcoming opportunities modified nanomedicine from drug gene delivery, bioimaging, biosensing perspectives.

Язык: Английский

Процитировано

46
Effect of Shape and Size on Synthesized Triple (Co/Ni/Zn)-Doped α-Fe2O3 Nanoparticles on their Photocatalytic and Scavenging Properties DOI
Naveen Thakur, Pankaj Kumar

International Journal of Nanoscience, Год журнала: 2024, Номер unknown

Опубликована: Фев. 14, 2024

Co/Ni/Zn triple doped [Formula: see text]-Fe 2 O 3 nanoparticles (NPs) have been synthesized via polyvinylpyrrolidone (PVP)/Azadirachta indica (A. Indica) leaf extract coating. XRD, UV–Vis, SEM, TEM, EDS, Raman spectroscopy, FTIR, VSM were used to characterize the NPs. XRD pattern revealed that crystallite size of NPs ranges from 14[Formula: text]nm 21[Formula: text]nm. Spherical found by SEM/TEM examination ranging 16[Formula: 26[Formula: Analysis magnetic properties antiferromagnetic characteristics, convergence between magnetization curves (MS), and switching field distribution dM/dh below an irreversible temperature text][Formula: text]K. Produced catalyst was for degradation anionic azo dye Malachite green (MG) Rhodamine blue (RhB) dyes under influence UV radiation. RhB MG reduced as a result catalyzing conversion dissolved hydroxyl radicals (OH) when exposed visible light. This shows main active radical specifically engaged in photo-catalytic breakdown is OH. The most effective photo-catalyst determined investigating proposed reusability over three cycles. retrieved utilized times after reaction without suffering substantial loss catalytic activity. plant-mediated significant antioxidant activity due their higher phenolic content. These promising future with potential applications health, aging, food preservation, cosmetics, agriculture environmental protection.

Язык: Английский

Процитировано

10
Biosynthesis of ZnO.Ag2O3 using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells DOI Creative Commons
M. Halimi, Mohabat Nadaf, Mohammad Ehsan Taghavizadeh Yazdi

и другие.

Micro & Nano Letters, Год журнала: 2023, Номер 18(6)

Опубликована: Июнь 1, 2023

Abstract The zinc oxide‐silver oxide nanocomposite (ZnO.Ag 2 O 3 particles) was prepared by using an aqueous plant extract of Haplophyllum obtusifolium for the first time. Powder X‐ray diffraction (PXRD), Fourier transforms spectroscopy (FTIR), field emission microscopy (FESEM), energy dispersive analysis (EDX), and transmission electron (TEM) were applied to analyze structure, functional groups, morphology, purity nanocomposite. PXRD revealed formulation ZnO.Ag particles. investigation groups has demonstrated presence some carbonated impurities along with absorbed water in composition Morphologically, particles have formed a petal‐like shape different sizes. EDX also confirmed sample 4.78% silver formula. Additionally, TEM spherical rectangular shapes particle size 80.43 ± 46.73 nm. Moreover, used against cancer cells, which shown synthesized NCs toxic effect liver cells concentration time‐dependent manner.

Язык: Английский

Процитировано

20
Biocompatible polymer functionalized magnetic nanoparticles for antimicrobial and anticancer activities DOI
Tariq Munir, Arslan Mahmood, Azhar Rasul

и другие.

Materials Chemistry and Physics, Год журнала: 2023, Номер 301, С. 127677 - 127677

Опубликована: Март 28, 2023

Язык: Английский

Процитировано

18
Advanced nanoscale drug delivery systems for bone cancer therapy DOI Creative Commons
Nazanin Amiryaghoubi, Marziyeh Fathi, Jaleh Barar

и другие.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2023, Номер 1869(6), С. 166739 - 166739

Опубликована: Май 3, 2023

Язык: Английский

Процитировано

14
Novel targeted delivery of quercetin for human hepatocellular carcinoma using starch/polyvinyl alcohol nanocarriers based hydrogel containing Fe2O3 nanoparticles DOI

Afsaneh Mojtahedzadeh Asl,

Mohammadreza Kalaee, Majid Abdouss

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 257, С. 128626 - 128626

Опубликована: Дек. 5, 2023

Язык: Английский

Процитировано

14
A narrative review on the use of Green synthesized metallic nanoparticles for targeted cancer therapy DOI
Prashant Kumar, Sumel Ashique, Himanshu Sharma

и другие.

Bioorganic Chemistry, Год журнала: 2025, Номер 157, С. 108305 - 108305

Опубликована: Фев. 23, 2025

Язык: Английский

Процитировано

0
Drug delivery and anticancer activity of biosynthesised mesoporous Fe2O3nanoparticles DOI
Firoozeh Abolhasani Zadeh, Saade Abdalkareem Jasim,

N. E. Atakhanova

и другие.

IET Nanobiotechnology, Год журнала: 2022, Номер 16(3), С. 85 - 91

Опубликована: Март 16, 2022

Mesoporous magnetic nanoparticles of haematite were synthesised using plant extracts according to bioethics principles. The structural, physical and chemical properties mesoporous Fe2 O3 with the green chemistry approach evaluated by XRD, SEM, EDAX, BET, VSM HRTEM analysis. Then, their toxicity against normal HUVECs MCF7 cancer cells was MTT assay for 48 h. These biogenic have over 71% doxorubicin loading efficiency, resulting in a 50% reduction at 0.5 μg.ml-1 concentration. Therefore, it is suggested that be used as multifunctional agent medicine (therapeutic-diagnostic). produced its inherent structural such polygonal structure (increasing surface area particle volume) porosity large pore volume became suitable substrate anti-cancer drug doxorubicin.

Язык: Английский

Процитировано

18