Mosquito-Borne Diseases and Their Control Strategies: An Overview Focused on Green Synthesized Plant-Based Metallic Nanoparticles

Insects, Год журнала: 2023, Номер 14(3), С. 221 - 221

Опубликована: Фев. 23, 2023

Mosquitoes act as vectors of pathogens that cause most life-threatening diseases, such malaria, Dengue, Chikungunya, Yellow fever, Zika, West Nile, Lymphatic filariasis, etc. To reduce the transmission these mosquito-borne diseases in humans, several chemical, biological, mechanical, and pharmaceutical methods control are used. However, different strategies facing important timely challenges include rapid spread highly invasive mosquitoes worldwide, development resistance mosquito species, recent outbreaks novel arthropod-borne viruses (e.g., Rift Valley tick-borne encephalitis, yellow etc.). Therefore, effective is urgently needed to manage vectors. Adapting principles nanobiotechnology vector one current approaches. As a single-step, eco-friendly, biodegradable method does not require use toxic chemicals, green synthesis nanoparticles using active agents from plant extracts available since ancient times exhibits antagonistic responses broad-spectrum target-specific activities against species mosquitoes. In this article, state knowledge on general, repellent mosquitocidal plant-mediated particular, has been reviewed. By doing so, review may open new doors for research diseases.

Язык: Английский

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Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions

Natural Product Reports, Год журнала: 2023, Номер 40(12), С. 1901 - 1937

Опубликована: Янв. 1, 2023

Major advances have recently been made in understanding the biosynthesis and emission of floral volatiles, how their is shaped by abiotic biotic factors, which volatiles are involved communicating with mutualists parasites.

Язык: Английский

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Traveling across Life Sciences with Acetophenone—A Simple Ketone That Has Special Multipurpose Missions

Molecules, Год журнала: 2023, Номер 28(1), С. 370 - 370

Опубликована: Янв. 2, 2023

Each metabolite, regardless of its molecular simplicity or complexity, has a mission function in the organism biosynthesizing it. In this review, biological, allelochemical, and chemical properties acetophenone, as metabolite involved multiple interactions with various (mi-cro)organisms, are discussed. Further, details biogenesis synthesis provided, possibility application different areas life sciences, i.e., status quo acetophenone simple substituted analogs, is examined. particular, natural synthetic derivatives analyzed promising agrochemicals useful scaffolds for drug research development.

Язык: Английский

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Current evidences of the efficacy of mosquito mass-trapping interventions to reduce Aedes aegypti and Aedes albopictus populations and Aedes-borne virus transmission

PLoS neglected tropical diseases, Год журнала: 2023, Номер 17(3), С. e0011153 - e0011153

Опубликована: Март 6, 2023

Background Over the past decades, several viral diseases transmitted by Aedes mosquitoes—dengue, chikungunya, Zika—have spread outside of tropical areas. To limit transmission these viruses and preserve human health, use mosquito traps has been developed as a complement or alternative to other vector control techniques. The objective this work was perform systematic review existing scientific literature assess efficacy interventions based on adult trap population densities they transmit worldwide. Methods findings Following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines, conducted using PubMed Scopus databases. Among 19 selected papers, lethal ovitraps were used in 16 studies, host-seeking female 3 studies. Furthermore, studies focused Ae . aegypti Our showed great heterogeneity indicators efficacy: e.g., number females, gravid proportion positive containers, infection rate mosquitoes serological residents. Regardless type studied traps, results various support mass trapping combination with classical integrated reducing density. More standardized methodology, are urgently needed provide more accurate estimates their efficacy. Conclusions This highlights gaps demonstration disease. Thus, further large-scale cluster randomized controlled trials endemic areas including epidemiological outcomes establish evidence reduction risk targeting and/or mosquitoes.

Язык: Английский

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Development and laboratory validation of a plant-derived repellent blend, effective against Aedes aegypti [Diptera: Culicidae], Anopheles gambiae [Diptera: Culicidae] and Culex quinquefasciatus [Diptera: Culicidae]

PLoS ONE, Год журнала: 2024, Номер 19(3), С. e0299144 - e0299144

Опубликована: Март 21, 2024

Mosquitoes of the genera Aedes , Anopheles and Culex vector a wide range pathogens seriously affecting humans livestock on global scale. Over-reliance insecticides repellents has driven research into alternative, naturally-derived compounds to fulfil same objectives. Steam distilled extracts four plants with strong, yet attractive, volatile profiles were initially assessed for repellency in dual-port olfactometer using aegypti as model species. Picea sitchensis was found be most repellent, proving comparable leading products when applied at 100% (p = 1.000). Key components conifer-derived then screened via electroantennography before those eliciting an electrophysiological response assayed individually olfactometer; according WHO protocol. The promising 5 selected reductive analyses produce optimised semiochemical blend. This combination, further two variations blend, progressed multi-species analysis BG-test whereby bite-attempt frequency hands under different repellent treatments; assays compared between gambiae quinquefasciatus . Efficacy against all three species, although it that Ae. susceptible An. being least. Here, novel, blend is presented weak spatial repellency, confirmed laboratory assays. Further work will required assess full extent potential products, both terms field application species screening; however, success developed demonstrate plant metabolites have great capacity use sector; improve upon known reduce usage toxic currently market.

Язык: Английский

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Smelly interactions: host-borne volatile organic compounds triggering behavioural responses in mosquitoes, sand flies, and ticks

Parasites & Vectors, Год журнала: 2024, Номер 17(1)

Опубликована: Май 16, 2024

Volatile organic compounds (VOCs) are chemicals emitted as products of cell metabolism, which reflects the physiological and pathological conditions any living organisms. These play a key role olfactory cues for arthropod vectors such mosquitoes, sand flies, ticks, act in transmission pathogens to many animal species, including humans. Some VOCs may influence behaviour, e.g., host preference oviposition site selection gravid females. Furthermore, deadly vector-borne Plasmodium falciparum Leishmania infantum suggested manipulate profile make them more attractive mosquitoes fly vectors, respectively. Under above circumstances, studies on these have demonstrated their potential usefulness investigating behavioural response ticks toward vertebrate hosts, well tools diagnosis diseases (VBDs). Herein, we provide an account scientific data available study seeking behaviour attractants, repellents, or early VBDs.

Язык: Английский

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Sebaceous origins of human odor

Current Biology, Год журнала: 2025, Номер 35(8), С. R303 - R313

Опубликована: Апрель 1, 2025

Язык: Английский

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Variability in human attractiveness to mosquitoes

Current Research in Parasitology and Vector-Borne Diseases, Год журнала: 2021, Номер 1, С. 100058 - 100058

Опубликована: Янв. 1, 2021

Blood-feeding mosquitoes locate humans spatially by detecting a combination of human-derived chemical signals, including carbon dioxide, lactic acid, and other volatile organic compounds. Mosquitoes use these signals to differentiate from animals. Spatial abiotic factors (e.g. humidity, heat) are also used find host. cause discomfort harm humans, being vectors many pathogens. However, not all suffer mosquito bites with the same frequency or intensity. Some individuals more attractive than others, this has an important impact on risk infection pathogens transmitted vectors, such as arboviruses malaria parasites. Variability in human attractiveness is partially due individual characteristics composition intensity release attractants. The that determine particularities diverse, modestly understood still quite controversial. Thus, review discusses role pregnancy, parasites (Plasmodium spp.), skin microbiota, diet, genetics mosquitoes. In brief, pregnancy Plasmodium increase host Skin microbiota (especially HLA alleles) modulate production attractants therefore influence susceptibility insects. There evidence pointing diet mosquitoes, some dietary components having bigger others. last part review, affecting human-mosquito interactions debated, special focus genetics, environmental wind, disturbances). This work highlights composed different human-associated components, factors, characteristics. Understanding importance how they interact each other, essential for development better control strategies studies focused infectious disease dynamics.

Язык: Английский

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Recent Advancements in Pathogenic Mechanisms, Applications and Strategies for Entomopathogenic Fungi in Mosquito Biocontrol

Journal of Fungi, Год журнала: 2023, Номер 9(7), С. 746 - 746

Опубликована: Июль 13, 2023

Fungal diseases are widespread among insects and play a crucial role in naturally regulating insect populations. Mosquitoes, known as vectors for numerous infectious diseases, pose significant threat to human health. Entomopathogenic fungi (EPF) have emerged highly promising alternative agents chemical mosquitocides controlling mosquitoes at all stages of their life cycle due unique infection pathway through direct contact with the insect’s cuticle. In recent years, advancements been made understanding pathways pathogenic mechanisms EPF against mosquitoes. Various strategies involving use alone or combinations other approaches employed target various developmental stages. Moreover, application genetic technologies has opened up new avenues enhancing mosquitocidal efficacy EPF. This review presents comprehensive summary our EPF, applications mosquito management, combination employment transgenic technologies. The biosafety concerns associated corresponding also discussed. progress suggests that potential serve future biorational tool vectors.

Язык: Английский

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Skin bacterial volatiles: propelling the future of vector control

Trends in Parasitology, Год журнала: 2021, Номер 38(1), С. 15 - 22

Опубликована: Сен. 18, 2021

Язык: Английский

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