Aggregation-Induced Luminescent 3-Phenylpyrano[4,3-b]quinolizine Derivatives as Photosensitizers with Anti-Cancer Properties

Molecules, Год журнала: 2025, Номер 30(7), С. 1422 - 1422

Опубликована: Март 23, 2025

Photodynamic therapy (PDT) has garnered significant attention as an effective and safe method for cancer therapy, with ongoing efforts to develop new photosensitizers enhance its efficacy. This study aimed novel aggregation-induced emission enhancement (AIEE) properties. A series of 3-phenyl pyrano[4,3-b]quinolizine compounds (3–10) were synthesized by reacting pyrones (1a–e) 2-pyridylacetate (2a) or 2-pyridylacetonitrile (2b) then evaluated their potential photosensitizers. Spectroscopic analyses revealed that all emitted blue green fluorescence in ethanol, wavelengths ranging from 446 nm 515 nm. Compounds 5 6, lacking a substituent at position pyrano[4,3-b]quinolizine, exhibited AIEE behavior aqueous solution. Furthermore, produced reactive oxygen species upon exposure LED light. Notably, 6 demonstrate high singlet (1O2) generation efficiency water-rich solvents, where they tend aggregate, contributing destroy cells. In vitro studies using human colon cells (Colo205) demonstrated potent anti-tumor activity These findings suggest based on possessing properties, are PDT.

Язык: Английский

A Novel Ethylenediamine Bridged Indole-BODIPY Schiff Base Applied for Selective Response to Fe, Cu and Al Detection

Journal of Fluorescence, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Язык: Английский