Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 19, 2025

Abstract Exosomes (Exos), also known as small extracellular vesicles, are naturally occurring nanoparticles (NPs), which characterized by their nanometer size and negative charged in physiological environments. While it is widely accepted that proteins biological compounds adhere to different nanomaterials (NMs), forming an outer layer the biomolecule corona (BC), detailed understanding of factors contributing BC formation well its effects remains limited. Studies have shown can affect physicochemical properties synthetic natural NPs once contacting fluids. Here, we present a study investigating novel concept exosomal formation, contrast well-documented mainly consists Exos/exosomal components. For this purpose, peptide-based Fmoc-Lysine (Fmoc-Lys) NMs were synthesized characterized, interaction studies with (cancer) cell-derived Exos performed. Measurements size, zeta potential, colloidal stability indicate formation. Furthermore, cell viability experiments showed Exo-NM resulted reduced nanotoxicity profile indicating practical relevance for applications these NMs. In summary, here provide first evidence supporting around should become part evaluating interactions at nano-bio-interfaces.

Язык: Английский