medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Abstract
Diagnostic
models
using
primary
care
routine
clinical
variables
have
been
limited
in
their
ability
to
identify
Alzheimer’s
disease
(AD)
patients.
In
this
study
we
sought
better
understand
the
effect
of
mild
cognitive
impairment
(MCI)
on
predictive
performance
AD
diagnostic
models.
We
sourced
data
from
Disease
Neuroimaging
Initiative
(ADNI)
cohort.
CatBoost
was
used
assess
utility
that
are
accessible
physicians,
such
as
hematological
and
blood
tests
medical
history,
multiclass
classification
between
healthy
controls,
MCI,
AD.
Our
results
indicated
MCI
indeed
affected
Of
three
subgroups
found,
finding
driven
by
a
subgroup
patients
likely
prodromal
Future
research
should
focus
distinguishing
utmost
priority
for
improving
translational
physicians.
Mathematics,
Год журнала:
2024,
Номер
12(14), С. 2204 - 2204
Опубликована: Июль 13, 2024
Alzheimer’s
disease
(AD)
is
a
growing
public
health
crisis,
very
global
concern,
and
an
irreversible
progressive
neurodegenerative
disorder
of
the
brain
for
which
there
still
no
cure.
Globally,
it
accounts
60–80%
dementia
cases,
thereby
raising
need
accurate
effective
early
classification.
The
proposed
work
used
healthy
aging
dataset
from
USA
focused
on
three
transfer
learning
approaches:
VGG16,
VGG19,
Alex
Net.
This
leveraged
how
convolutional
model
pooling
layers
to
improve
reduce
overfitting,
despite
challenges
in
training
numerical
dataset.
VGG
was
preferably
chosen
as
hidden
layer
has
more
diverse,
deeper,
simpler
architecture
with
better
performance
when
dealing
larger
datasets.
It
consumes
less
memory
time.
A
comparative
analysis
performed
using
machine
neural
network
algorithm
techniques.
Performance
metrics
such
accuracy,
error
rate,
precision,
recall,
F1
score,
sensitivity,
specificity,
kappa
statistics,
ROC,
RMSE
were
experimented
compared.
accuracy
100%
VGG16
VGG19
98.20%
precision
99.9%
96.6%
Net;
recall
values
all
cases
sensitivity
metric
96.8%
97.9%
98.7%
Net,
outperformed
compared
existing
approaches
classification
disease.
research
contributes
advancement
predictive
knowledge,
leading
future
empirical
evaluation,
experimentation,
testing
biomedical
field.
Epilepsy & Behavior,
Год журнала:
2024,
Номер
154, С. 109735 - 109735
Опубликована: Март 23, 2024
Seizure
events
can
manifest
as
transient
disruptions
in
the
control
of
movements
which
may
be
organized
distinct
behavioral
sequences,
accompanied
or
not
by
other
observable
features
such
altered
facial
expressions.
The
analysis
these
clinical
signs,
referred
to
semiology,
is
subject
observer
variations
when
specialists
evaluate
video-recorded
setting.
To
enhance
accuracy
and
consistency
evaluations,
computer-aided
video
seizures
has
emerged
a
natural
avenue.
In
field
medical
applications,
deep
learning
computer
vision
approaches
have
driven
substantial
advancements.
Historically,
been
used
for
disease
detection,
classification,
prediction
using
diagnostic
data;
however,
there
limited
exploration
their
application
evaluating
video-based
motion
detection
epileptology
While
vision-based
technologies
do
aim
replace
expertise,
they
significantly
contribute
decision-making
patient
care
providing
quantitative
evidence
decision
support.
Behavior
monitoring
tools
offer
several
advantages
objective
information,
detecting
challenging-to-observe
events,
reducing
documentation
efforts,
extending
assessment
capabilities
areas
with
expertise.
main
applications
could
(1)
improved
seizure
methods;
(2)
refined
semiology
predicting
type
cerebral
localization.
this
paper,
we
detail
foundation
systems
videos,
highlighting
success
analysis,
focusing
on
work
published
last
7
years.
We
systematically
present
methods
indicate
how
adoption
recordings
approached.
Additionally,
illustrate
existing
interconnected
through
an
integrated
system
analysis.
Each
module
customized
adapting
more
accurate
robust
evolve.
Finally,
discuss
challenges
research
directions
future
studies.
Neuroimaging
experts
in
biotech
industries
can
benefit
from
using
cutting-edge
artificial
intelligence
techniques
for
Alzheimer’s
disease
(AD)-
and
dementia-stage
prediction,
even
though
it
is
difficult
to
anticipate
the
precise
stage
of
dementia
AD.
Therefore,
we
propose
a
cutting-edge,
computer-assisted
method
based
on
an
advanced
deep
learning
algorithm
differentiate
between
people
with
varying
degrees
dementia,
including
healthy,
very
mild
moderate
classes.
In
this
paper,
four
separate
models
were
developed
classifying
different
stages:
convolutional
neural
networks
(CNNs)
built
scratch,
pre-trained
VGG16
additional
layers,
graph
(GCNs),
CNN-GCN
models.
The
CNNs
implemented,
then
flattened
layer
output
was
fed
GCN
classifier,
resulting
proposed
architecture.
A
total
6400
whole-brain
magnetic
resonance
imaging
scans
obtained
Disease
Initiative
database
train
evaluate
methods.
We
applied
5-fold
cross-validation
(CV)
technique
all
presented
results
best
fold
out
five
folds
assessing
performance
study.
Hence,
CV,
above-mentioned
achieved
overall
accuracy
43.83%,
71.17%,
99.06%,
100%,
respectively.
model,
particular,
demonstrates
excellent
stages
dementia.
Understanding
assist
industry
researchers
uncovering
molecular
markers
pathways
connected
each
stage.
Biomedicines,
Год журнала:
2023,
Номер
11(2), С. 439 - 439
Опубликована: Фев. 2, 2023
Dementia
is
a
cognitive
disorder
that
mainly
targets
older
adults.
At
present,
dementia
has
no
cure
or
prevention
available.
Scientists
found
symptoms
might
emerge
as
early
ten
years
before
the
onset
of
real
disease.
As
result,
machine
learning
(ML)
scientists
developed
various
techniques
for
prediction
using
symptoms.
However,
these
methods
have
fundamental
limitations,
such
low
accuracy
and
bias
in
models.
To
resolve
issue
proposed
ML
model,
we
deployed
adaptive
synthetic
sampling
(ADASYN)
technique,
to
improve
accuracy,
novel
feature
extraction
techniques,
namely,
battery
(FEB)
optimized
support
vector
(SVM)
radical
basis
function
(rbf)
classification
The
hyperparameters
SVM
are
calibrated
by
employing
grid
search
approach.
It
evident
from
experimental
results
newly
pr
oposed
model
(FEB-SVM)
improves
conventional
6%.
obtained
98.28%
on
training
data
testing
93.92%.
Along
with
precision
91.80%,
recall
86.59,
F1-score
89.12%,
Matthew's
correlation
coefficient
(MCC)
0.4987.
Moreover,
outperforms
12
state-of-the-art
models
researchers
recently
presented
prediction.
Artificial
intelligence
(AI)
in
healthcare
describes
algorithm-based
computational
techniques
which
manage
and
analyse
large
datasets
to
make
inferences
predictions.
There
are
many
potential
applications
of
AI
the
care
older
people,
from
clinical
decision
support
systems
that
can
identification
delirium
records
wearable
devices
predict
risk
a
fall.
We
held
four
meetings
clinicians
researchers.
Three
priority
areas
were
identified
for
application
people.
These
included:
monitoring
early
diagnosis
disease,
stratified
coordination
between
providers.
However,
also
highlighted
concerns
may
exacerbate
health
inequity
people
through
bias
within
models,
lack
external
validation
amongst
infringements
on
privacy
autonomy,
insufficient
transparency
models
safeguarding
errors.
Creating
effective
interventions
requires
person-centred
approach
account
needs
as
well
sufficient
technological
governance
meet
standards
generalisability,
effectiveness.
Education
patients
is
needed
ensure
appropriate
use
technologies,
with
investment
infrastructure
required
equity
access.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 8, 2024
Dementia
is
a
condition
(a
collection
of
related
signs
and
symptoms)
that
causes
continuing
deterioration
in
cognitive
function,
millions
people
are
impacted
by
dementia
every
year
as
the
world
population
continues
to
rise.
Conventional
approaches
for
determining
rely
primarily
on
clinical
examinations,
analyzing
medical
records,
administering
neuropsychological
testing.
However,
these
methods
time-consuming
costly
terms
treatment.
Therefore,
this
study
aims
present
noninvasive
method
early
prediction
so
preventive
steps
should
be
taken
avoid
dementia.
Buildings,
Год журнала:
2025,
Номер
15(2), С. 288 - 288
Опубликована: Янв. 19, 2025
Soils
may
not
always
be
suitable
to
fulfill
their
intended
function.
Soil
improvement
can
achieved
by
mechanical
or
chemical
methods,
especially
in
transportation
facilities.
L
and
FA
additives
are
frequently
used
as
additives.
In
this
study,
two
natural
clay
samples
with
extreme
very
high
plasticity
were
improved
using
admixtures,
properties
under
static
repeated
loads
investigated
ML
methods.
Two
soil
from
different
sites
analyzed.
eight
datasets
used.
There
14
inputs,
including
specific
gravity
(Gs),
void
ratio
(eo),
sieve
analysis
(+No.4,
−No.200),
size,
LL,
plastic
limit
(PL),
index
(PI),
linear
shrinkage
(Ls),
(SL),
cure
day,
agent,
type,
agent
percentage.
The
outputs
swelling
(compressive,
percent),
compressive
strengths,
modulus
of
elasticity,
compressibility
soaked
non-soaked
conditions.
Prediction
is
attempted
(ML)
techniques.
techniques
for
regression
(such
Decision
Tree
Regression
(DTR)
K-nearest
neighbors
(KNN)).
SHapley
Additive
Explanations
(SHAP),
the
impact
inputs
on
observed,
it
was
generally
found
that
PL
LL
had
highest
outputs.
Different
performance
metrics
evaluation.
results
showed
these
predict
cyclic
extremely
clays
(R2
>
0.99).
These
highlight
general
applicability
models
containing
properties.