Design of Highly Porous Materials Based on Chitosan/Pectin Interpolyelectrolyte Complex for Wound Healing Application

Advances in Polymer Technology, Год журнала: 2024, Номер 2024, С. 1 - 14

Опубликована: Май 9, 2024

Interpolyelectrolyte complexes (IPECs) of polysaccharides are multifunctional polymer materials that improve the mechanical and physicochemical properties individual polysaccharides. In this study, highly porous (>90%) based on IPECs versatile natural polysaccharides, chitosan (30 1,200 kDa) pectin, obtained by freeze-drying technique. To enhance interaction between pectin macromolecules, latter chemically functionalized with dialdehyde groups. The chitosan-/aldehyde-functionalized (Chit/AF-Pect) polyelectrolyte complex sponges characterized using SEM, FTIR spectroscopy, TGA. swelling capacity study reveals a higher ratio IPEC an increase in both molecular weight content chitosan: for Chit30/AF-Pect, rises from 327% to 480%, while Chit1200/AF-Pect, 681% 1,066%. Additionally, vitro degradation test demonstrates stability Chit1200/AF-Pect comparison those Chit30/AF-Pect: after 4 days incubation, losses found be 9%–16% 18%–41%, respectively. cytotoxicity shows Chit30/AF-Pect noncytotoxic, cell viability values >70%. Furthermore, sponges, at chitosan:pectin 5:1, exhibit bactericidal activity against Escherichia coli BIM B-984 G, Pseudomonas aeruginosa B-807 Staphylococcus aureus B-1841, slightly inhibit growth Enterococcus faecalis B-1530 G. These findings indicate can used create wound dressings healing applications.

Язык: Английский

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Antimicrobial materials based on photothermal action and their application in wound treatment

Burns & Trauma, Год журнала: 2024, Номер 12

Опубликована: Янв. 1, 2024

Considering the increasing abundance of antibiotic-resistant bacteria, novel antimicrobial approaches need to be investigated. Photothermal therapy (PTT), an innovative noninvasive therapeutic technique, has demonstrated significant potential in addressing drug-resistant bacteria and bacterial biofilms. However, when used isolation, PTT requires higher-temperature conditions effectively eradicate thereby potentially harming healthy tissues inducing new inflammation. This study aims present a comprehensive review nanomaterials with intrinsic properties, materials relying on photothermal action, using drug delivery along their applications antimicrobials. Additionally, synergistic mechanisms these are elucidated. The provides reference for developing multifunctional nanoplatforms treating bacterially infected wounds.

Язык: Английский

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Invasive bacteriophages between a bell and a hammer: a comprehensive review of pharmacokinetics and bacterial defense systems

Discover Life, Год журнала: 2025, Номер 55(1)

Опубликована: Апрель 3, 2025

Язык: Английский

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Bacteriophage entrapment strategies for the treatment of chronic wound infections: a comprehensive review

Archives of Microbiology, Год журнала: 2024, Номер 206(11)

Опубликована: Окт. 23, 2024

Язык: Английский

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