Molecules, Год журнала: 2025, Номер 30(7), С. 1572 - 1572

Опубликована: Март 31, 2025

Peptide-functionalized nanomedicine has emerged as a transformative approach in precision therapeutics and diagnostics, leveraging the specificity of peptides to enhance performance nanocarriers, including gold nanoparticles, polymeric liposomes, mesoporous silica quantum dots. These systems enable targeted drug delivery, molecular imaging, biosensing, regenerative medicine, offering unparalleled advantages bioavailability, cellular uptake, therapeutic selectivity. This review provides comprehensive analysis peptide-functionalization strategies, nanocarrier design, their applications across oncology, neurodegenerative disorders, inflammatory diseases, infectious tissue engineering. We further discuss critical role physicochemical characterization, vitro vivo validation, regulatory considerations translating these technologies into clinical practice. Despite rapid progress peptide-functionalized platforms, challenges related stability, immune response, off-target effects, large-scale reproducibility remain key obstacles widespread adoption. Addressing through advanced peptide engineering, optimized synthesis methodologies, harmonization will be essential for integration. By bridging fundamental research with translational advancements, this an interdisciplinary roadmap next generation nanomedicines poised revolutionize therapy diagnostics.

Язык: Английский