3D-Printed Hydrogel Scaffolds Loaded with Flavanone@ZIF-8 Nanoparticles for Promoting Bacteria-Infected Wound Healing DOI Creative Commons
Jian Yu, Xin Huang, Fang‐Ying Wu

и другие.

Gels, Год журнала: 2024, Номер 10(12), С. 835 - 835

Опубликована: Дек. 18, 2024

Bacterial-infected skin wounds caused by trauma remain a significant challenge in modern medicine. Clinically, there is growing demand for wound dressings with exceptional antibacterial activity and robust regenerative properties. To address the need, this study proposes novel multifunctional dressing designed to combine efficient gas exchange, effective microbial barriers, precise drug delivery capabilities, thereby promoting cell proliferation accelerating healing. This work reports development of 3D-printed hydrogel scaffold incorporating flavanone (FLA)-loaded ZIF-8 nanoparticles (FLA@ZIF-8 NPs) within composite matrix κ-carrageenan (KC) konjac glucomannan (KGM). The forms stable dual-network structure through chelation KC potassium ions intermolecular hydrogen bonding between KGM. not only enhances mechanical stability but also improves its adaptability complex environments. In mildly acidic conditions, FLA@ZIF-8 NPs release Zn2+ controlled manner, providing sustained effects vivo studies using rat full-thickness infected model demonstrated that FLA@ZIF-8/KC@KGM significantly accelerated healing, showcasing superior performance treatment wounds.

Язык: Английский

Enhanced Osteogenic Differentiation of hMSCs Using BMP@ZIF-8-Loaded GelMA Nanocomposite Hydrogels with Controlled BMP-2 Release DOI Creative Commons
Weihao Yuan, Luiza de Almeida Queiroz Ferreira,

Ronit Khade

и другие.

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Hydrogels are highly versatile materials with immense potential for tissue engineering and regenerative medicine owing to their biocompatibility, tunable mechanical properties, ability mimic the natural extracellular matrix. Their 3D porous structure allows encapsulation delivery of bioactive molecules, making them ideal candidates drug systems. In repair, particularly bone regeneration, hydrogels can serve as carriers that release therapeutic agents in a controlled manner, thus enhancing healing process. Zeolitic Imidazolate Framework-8 (ZIF-8) nanoparticles recombinant human Bone Morphogenetic Protein (rhBMP-2) molecules were incorporated solely (ZIF@GelMA) or association (BMP@ZIF@GelMA) into gelatin modified by methacryloyl hydrogel (GelMA) investigate its physical osteogenic properties. characterized Scanning Electron Microscopy rheological tests. We analyzed degradation BSA profile BMP@ZIF@GelMA samples throughout 0, 1, 3, 7, 14, 28 days. Cell adhesion formation markers hydrogel-encapsulated dental pulp cells using immunocytochemistry molecular analysis. ZIF@GelMA exhibited viscoelastic increased storage modulus when rhBMP2 was present. BSA@ZIF@GelMA showed balanced rate BSA. The upregulated expression cell genes, BMP-2 introduced, levels remarkably elevated. presents several favorable factors promote cellular encouraging further prospects advanced applications repair.

Язык: Английский

Процитировано

0
Recent development of ZiF-8 incorporated dressings for wound healing application: Current Insight and Future Perspective DOI

Muhammad Shahzad Zafar,

Muhammad Umar Aslam Khan, Mohd Faizal Abdullah

и другие.

Materials Today Communications, Год журнала: 2025, Номер unknown, С. 112652 - 112652

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
3D-Printed Hydrogel Scaffolds Loaded with Flavanone@ZIF-8 Nanoparticles for Promoting Bacteria-Infected Wound Healing DOI Creative Commons
Jian Yu, Xin Huang, Fang‐Ying Wu

и другие.

Gels, Год журнала: 2024, Номер 10(12), С. 835 - 835

Опубликована: Дек. 18, 2024

Bacterial-infected skin wounds caused by trauma remain a significant challenge in modern medicine. Clinically, there is growing demand for wound dressings with exceptional antibacterial activity and robust regenerative properties. To address the need, this study proposes novel multifunctional dressing designed to combine efficient gas exchange, effective microbial barriers, precise drug delivery capabilities, thereby promoting cell proliferation accelerating healing. This work reports development of 3D-printed hydrogel scaffold incorporating flavanone (FLA)-loaded ZIF-8 nanoparticles (FLA@ZIF-8 NPs) within composite matrix κ-carrageenan (KC) konjac glucomannan (KGM). The forms stable dual-network structure through chelation KC potassium ions intermolecular hydrogen bonding between KGM. not only enhances mechanical stability but also improves its adaptability complex environments. In mildly acidic conditions, FLA@ZIF-8 NPs release Zn2+ controlled manner, providing sustained effects vivo studies using rat full-thickness infected model demonstrated that FLA@ZIF-8/KC@KGM significantly accelerated healing, showcasing superior performance treatment wounds.

Язык: Английский

Процитировано

0