Association of FTO protein with hyperandrogenism metabolic disturbances in women with polycystic ovary syndrome DOI Creative Commons

Sadaf Parveen,

Saba Khan, Shagufta Moin

и другие.

Endocrine Regulations, Год журнала: 2025, Номер 59(1), С. 33 - 41

Опубликована: Янв. 1, 2025

Abstract Objective. Polycystic ovary syndrome (PCOS) is one of the commonest endocrinopathies in women characterized by hyperandrogenism, ovulatory dysfunction, and insulin resistance affecting 5–20% reproductive-aged worldwide. Recent studies have emphasized role fat mass obesity-associated (FTO) gene development PCOS, specifically rs9939609 A/T polymorphism, which linked to an increased risk PCOS. The study aimed investigate levels FTO protein its association with luteinizing hormone (LH), follicle-stimulating (FSH) anthropometric parameters patients PCOS compared healthy controls. Materials. A total 298 women, comprising 149 controls, enrolled study. Anthropometric (body index, BMI; waist circumference, WC; hip HC; waist-to-hip ratio, WHR), hormonal assays (LH, FSH, LH/FSH ratio) were performed. measured ELISA kit their these was analyzed. receiver operator characteristic (ROC) curve analysis performed evaluate discriminatory power distinguishing cases value p<0.05 considered statistically significant. Results. significantly elevated BMI, WC, HC, WHR (p=<0.05). mean BMI showed a positive correlation both WC (r=0.367, p<0.001) HC (r=0.395, p<0.001). strongly correlated (r=0.780, (r=0.465, LH FSH (r=0.543, p<.001), (r=0.553, p<.001). (r=0.364, p<0.001), (r=0.166, Additionally, negative (r=–0.190, p<0.05), (r=–0.277, (r=–0.408 observed. higher Significant correlations also found between or parameters. AUC for 0.624 (p=0.550), indicating moderate power, but lacking statistical significance. Conclusion. that are correlating (increased LH, decreased FSH). This highlights potential involvement metabolic disturbances characteristics biomarker character condition.

Язык: Английский

Association of FTO protein with hyperandrogenism metabolic disturbances in women with polycystic ovary syndrome DOI Creative Commons

Sadaf Parveen,

Saba Khan, Shagufta Moin

и другие.

Endocrine Regulations, Год журнала: 2025, Номер 59(1), С. 33 - 41

Опубликована: Янв. 1, 2025

Abstract Objective. Polycystic ovary syndrome (PCOS) is one of the commonest endocrinopathies in women characterized by hyperandrogenism, ovulatory dysfunction, and insulin resistance affecting 5–20% reproductive-aged worldwide. Recent studies have emphasized role fat mass obesity-associated (FTO) gene development PCOS, specifically rs9939609 A/T polymorphism, which linked to an increased risk PCOS. The study aimed investigate levels FTO protein its association with luteinizing hormone (LH), follicle-stimulating (FSH) anthropometric parameters patients PCOS compared healthy controls. Materials. A total 298 women, comprising 149 controls, enrolled study. Anthropometric (body index, BMI; waist circumference, WC; hip HC; waist-to-hip ratio, WHR), hormonal assays (LH, FSH, LH/FSH ratio) were performed. measured ELISA kit their these was analyzed. receiver operator characteristic (ROC) curve analysis performed evaluate discriminatory power distinguishing cases value p<0.05 considered statistically significant. Results. significantly elevated BMI, WC, HC, WHR (p=<0.05). mean BMI showed a positive correlation both WC (r=0.367, p<0.001) HC (r=0.395, p<0.001). strongly correlated (r=0.780, (r=0.465, LH FSH (r=0.543, p<.001), (r=0.553, p<.001). (r=0.364, p<0.001), (r=0.166, Additionally, negative (r=–0.190, p<0.05), (r=–0.277, (r=–0.408 observed. higher Significant correlations also found between or parameters. AUC for 0.624 (p=0.550), indicating moderate power, but lacking statistical significance. Conclusion. that are correlating (increased LH, decreased FSH). This highlights potential involvement metabolic disturbances characteristics biomarker character condition.

Язык: Английский

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