PACAP inhibits sepsis-associated acute lung injury by inhibiting the Sp1/AQP1 pathway DOI
Z. Xiong, Xiaoqin Zhou,

Yufeng Li

и другие.

Peptides, Год журнала: 2025, Номер unknown, С. 171411 - 171411

Опубликована: Май 1, 2025

Язык: Английский

Glutathione Attenuates Diesel Exhaust-Induced Lung Epithelial Injury via NF-κB/Nrf2/GPX4-Mediated Ferroptosis DOI

Ekta Nagar,

Naresh Singh, Neeru Saini

и другие.

Toxicology, Год журнала: 2025, Номер unknown, С. 154154 - 154154

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Multi-omics integration reveals YWHAE as a key mediator of ferroptosis in ARDS DOI
Heng Cui, Xia Huang

Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 22, 2025

Язык: Английский

Процитировано

0
Has_circRNA_0122683 (circ-PRKCI) relieves ferroptosis of HPAEpiCs in sepsis-induced acute lung injury by sponging miR-382-5p DOI Creative Commons

Limei Yan,

Xiajun Lu,

Ning Wang

и другие.

PeerJ, Год журнала: 2025, Номер 13, С. e19404 - e19404

Опубликована: Май 13, 2025

Circular ribonucleic acid (RNA) protein kinase C iota (circ-PRKCI, hsa_circRNA_0122683) has been previously reported to be involved in the development of sepsis. However, knowledge regarding potential role and mechanism circ-PRKCI sepsis-induced acute lung injury (ALI) is unclear. An vitro cellular model sepsis-ALI was simulated by treatment lipopolysaccharide (LPS) human pulmonary alveolar epithelial cells (HPAEpiCs). The expression plasma samples from sepsis patients with or without ALI as well cell determined quantitative real-time PCR (qRT-PCR). diagnostic utility analyzed using receiver operating characteristic (ROC) curves. levels iron content (Fe2+), glutathione (GSH), malondialdehyde (MDA), reactive oxygen species (ROS) were detected corresponding commercial kits. assessment viability production pro-infammatory cytokines (IL-6, IL-1β TNF-α) measured Cell Counting Kit-8 (CCK-8) enzyme-linked immunosorbent assay (ELISA). targeting relationship between miR-382-5p predicted bioinformatics analysis, subsequently confirmed luciferase reporter RNA immunoprecipitation (RIP) assays. Results shows that decreased but increased observed model. area under curve values ROC curves for differentiating septic healthy individuals non-ALI 0.996 0.999, respectively. Functional assays revealed enforced alleviated LPS-induced ferroptosis inflammatory response HPAEpiCs, which reversed Erastin FIN56 administration. Mechanistically, identified a sponge negatively regulated expression. Further rescue experiments showed overexpression could compromise anti-ferroptosis anti-inflammatory effects on HPAEpiCs. Our study demonstrated may promising biomarker diagnosis. inhibits sponging miR-382-5p, indicating circ-PRKCI/miR-382-5p axis might novel therapeutic target ALI.

Язык: Английский

Процитировано

0
Zinc finger transcription factor ZNF384 mitigates LPS-induced ferroptosis and inflammation in lung epithelial cells by activating SESN2-mediated autophagy DOI

Lu Shi,

Hongxue Fu,

Yingting Hao

и другие.

Toxicology in Vitro, Год журнала: 2025, Номер unknown, С. 106073 - 106073

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
PACAP inhibits sepsis-associated acute lung injury by inhibiting the Sp1/AQP1 pathway DOI
Z. Xiong, Xiaoqin Zhou,

Yufeng Li

и другие.

Peptides, Год журнала: 2025, Номер unknown, С. 171411 - 171411

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0