Physical activity and exercise health benefits: cancer prevention, interception, and survival
European Journal of Cancer Prevention,
Год журнала:
2024,
Номер
34(1), С. 24 - 39
Опубликована: Май 29, 2024
Physical
activity
(PA)
has
an
established
role
in
the
promotion
of
health
and
fitness
prevention
disease.
Expected
overall
benefits
include
reduction
all-cause
morbidity
death,
weight
control,
improved
quality
life,
bone
decreased
falls
elderly
subjects,
,
deeper
cognition,
reduced
risk
depression,
anxiety,
sleeplessness.
Currently,
PA
is
a
mainstay
management
cardiovascular
diseases,
metabolic
syndrome,
diabetes,
health.
Recently,
perception
its
primary
secondary
prevention,
interception,
treatment
cancer,
however,
also
gaining
importance.
Regular
walking,
simplest
type
PA,
associated
with
disease
mortality,
cancer
increasing
interest.
Furthermore,
improves
life
patients,
attenuating
side
effects
chemotherapy,
decreasing
sarcopenia,
fitness,
inhibiting
recurrence
progression
some
types.
It
promotes
emotional
psychological
inducing
positive
changes.
While
mechanisms,
effective
levels
useful
amount
practice
are
well
cardiology,
they
yet
to
be
fully
determined
oncology.
Nevertheless,
recommended
reduce
general
population,
it
been
introduced
programs
for
second
cancers.
In
perspective,
will
help
as
integrative
therapy
patients
survivors.
The
number
beneficial
continuum
highlighted
this
review.
Язык: Английский
Exercise-driven cellular autophagy: A bridge to systematic wellness
Journal of Advanced Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Exercise
enhances
health
by
supporting
homeostasis,
bolstering
defenses,
and
aiding
disease
recovery.
It
activates
autophagy,
a
conserved
cellular
process
essential
for
maintaining
balance,
while
dysregulated
autophagy
contributes
to
progression.
Despite
extensive
research
on
exercise
independently,
their
interplay
remains
insufficiently
understood.
This
review
explores
the
molecular
mechanisms
of
exercise-induced
in
various
tissues,
focusing
key
transduction
pathways.
examines
how
different
types
trigger
specific
autophagic
responses,
balance
addressing
systemic
dysfunctions.
The
also
highlights
signaling
pathways
involved,
roles
protecting
organ
function,
reducing
risk,
promoting
longevity,
offering
clear
understanding
link
between
autophagy.
Exercise-induced
is
governed
highly
coordinated
dynamic
integrating
direct
indirect
mechanical
forces
biochemical
signals,
linking
physical
activity
across
multiple
systems.
Its
activation
influenced
modality,
intensity,
duration,
individual
biological
characteristics,
including
age,
sex,
muscle
fiber
composition.
Aerobic
exercises
primarily
engage
AMPK
mTOR
pathways,
mitochondrial
quality
homeostasis.
Anaerobic
training
PI3K/Akt
signaling,
modulating
molecules
like
FOXO3a
Beclin1
drive
repair.
In
pathological
contexts,
proteostasis,
tissue
regeneration,
benefiting
conditions
sarcopenia,
neurodegeneration,
myocardial
ischemia,
metabolic
disorders,
cancer.
However,
excessive
may
lead
overactivation,
leading
atrophy
or
cardiac
remodeling.
underscores
critical
need
balanced
regimens
maximize
therapeutic
efficacy
minimizing
risks.
Future
should
prioritize
identifying
reliable
biomarkers,
optimizing
protocols,
with
pharmacological
strategies
enhance
outcomes.
Язык: Английский
Exercise, exerkines and exercise mimetic drugs: Molecular mechanisms and therapeutics
Life Sciences,
Год журнала:
2024,
Номер
359, С. 123225 - 123225
Опубликована: Ноя. 9, 2024
Язык: Английский
Exploring Potential Diagnostic Biomarkers for Mechanical Asphyxia in the Heart Based on Proteomics Technology
Yuebing Huang,
Hai Qiu,
Qianling Chen
и другие.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12710 - 12710
Опубликована: Ноя. 26, 2024
Mechanical
asphyxia
presents
a
challenging
diagnostic
issue
in
forensic
medicine
due
to
its
often
covert
nature,
and
the
signs
visible
during
an
autopsy
are
usually
not
specific.
Despite
some
progress
understanding
hypoxia's
effects,
traditional
methods'
inherent
limitations
might
overlook
new
biomarkers
mechanical
asphyxia.
This
study
employed
4D-DIA
proteomics
explore
protein
expression
profiles
of
cardiac
samples
under
conditions
Proteomic
analysis
identified
271
371
differentially
expressed
proteins
strangulation
suffocation
groups,
respectively,
compared
control
group.
Seventy-eight
were
across
different
groups
GO
KEGG
showed
enrichment
pathways,
including
complement
coagulation
cascades,
cAMP
cGMP-PKG
signaling
inflammatory
mediator
regulation
TRP
channels,
phagosomes.
Through
stringent
selection
based
on
interactions,
ALKBH5,
NAA10,
CLPB
as
potential
biomarkers.
ALKBH5
increased
models,
while
NAA10
downregulated;
these
biomarker
changes
validated
both
animal
models
human
samples.
highlights
discovering
reliable
biomarkers,
which
can
enhance
specificity
diagnosis
practice,
provide
insights
into
pathophysiological
mechanisms
asphyxia,
offer
perspectives
for
diagnosing
Язык: Английский