Advances in Conductive Biomaterials for Cardiac Tissue Engineering: Design, Fabrication, and Functional Integration

Polymers, Год журнала: 2025, Номер 17(5), С. 620 - 620

Опубликована: Фев. 26, 2025

Heart failure functions as one of the leading global causes death because it falls under cardiovascular disease categories. Cardiac tissue engineering advances by developing new tissues to rebuild heart in individuals with damaged structures gives medical treatment possibilities patients reaching their final stage. Most consists cardiomyocytes which make up between 80 90 percent total organ space. The retain specialized cell structure includes elongation, but they align produce contractions span into length. After myocardial infarction, doctors need elastic soft platforms heal mimic its natural attributes. Special consideration must be paid material selection for appropriate mechanical properties, given that different substances have separate qualities. Stem survival becomes higher, and differentiation develops more efficiently when a proper scaffold design is implemented, thus enabling repair. Conductive biomaterials demonstrate best candidate status cardiac due ability both convey electrical signals boost biological actions well promote cellular communication. Scientists conduct life science research on stem cells present unique characteristics. Biomaterials conductive properties within help body recover while improving functionality myocardium. This article analyzes various used biomedical practices healing applications.

Язык: Английский

Formulation and Characterization of Teicoplanin Niosomal Gel for Healing Chronic Wounds Infected with Methicillin-Resistant Staphylococcus Aureus (MRSA)

Gels, Год журнала: 2025, Номер 11(4), С. 230 - 230

Опубликована: Март 22, 2025

Methicillin-resistant Staphylococcus aureus (MRSA) is recognized as a significant pathogen playing crucial role in causing bacterial infections of skin and soft tissues due to its high capacity for biofilm formation. Niosome-based gel systems offer potential enhancing transdermal drug delivery increasing the effectiveness loaded drugs. The current research investigates feasibility niosomal formulating topical administration teicoplanin (TEC). thin film hydration method was used niosome formulation composed nonionic surfactant, cholesterol, mPEG 2000. TEC prepared with adding hydroxypropyl methylcellulose (HPMC) Poloxamer 407 polymers system. physiochemical characteristics formulation, such particle morphology, size, zeta surface charge, homogeneity, encapsulation efficiency, vitro release, were evaluated. Also, antibacterial system analyzed. Further, we examined vivo activity synthesized on infected wounds Wister rats. We found that had anti-biofilm capabilities against MRSA isolates, could be an effective wound material preventing therapeutic problems related this superbug.

Язык: Английский

Biodegradable Natural Hydrogels: Design, Crosslinking, and Medical Applications

Materials Today Communications, Год журнала: 2025, Номер unknown, С. 112929 - 112929

Опубликована: Май 1, 2025

Язык: Английский