NK cellular derived nanovesicles in tumor immunity
Molecular Immunology,
Год журнала:
2025,
Номер
182, С. 54 - 61
Опубликована: Апрель 4, 2025
Natural
Killer
(NK)
cells
are
a
vital
element
of
the
innate
immune
system,
and
NK
cell-based
therapies
have
demonstrated
efficacy
against
various
malignancies.
However,
targeting
solid
tumors
has
been
challenging
due
to
low
infiltration
into
effective
evasion
strategies
employed
by
tumors.
Recent
studies
shown
that
cell
derived
nanovesicles
(NK-NV)
can
not
only
replicate
functions
but
also
offer
more
advantages
in
clinical
applications.
They
capable
transporting
cellular
components
such
as
proteins,
nucleic
acids,
lipids
across
distances,
thereby
facilitating
intercellular
communication
among
within
tumor
microenvironment
(TME).
With
progress
nanomedical
technology,
these
vesicles
be
engineered
carry
range
functional
elements
therapeutic
agents
enhance
their
antitumoral
capabilities.
In
this
review,
we
summarize
current
available
literature
on
NK-NVs,
discuss
potential
biological
role
non-coding
RNAs
(ncRNAs),
explore
application
treatment
Язык: Английский
The relationship of miR-155 host gene polymorphism in the susceptibility of cancer: a systematic review and meta-analysis
Frontiers in Genetics,
Год журнала:
2025,
Номер
16
Опубликована: Март 6, 2025
miR-155
is
overexpressed
in
many
cancers,
highlighting
its
potential
as
a
biomarker
for
cancer
diagnosis,
treatment,
and
therapeutic
evaluation.
processed
from
the
host
gene
(MIR155HG).
Genetic
variations
MIR155HG
may
influence
susceptibility,
but
existing
evidence
inconclusive.
This
study
aimed
to
evaluate
association
of
polymorphisms
with
risk.
A
systematic
literature
search
identified
15
case-control
studies
on
three
single
nucleotide
(SNPs):
rs767649
(T
>
A),
rs928883
(G
rs1893650
C).
Meta-analysis
was
performed
using
RevMan
5.4,
odds
ratios
(ORs)
95%
confidence
intervals
(CIs)
effect
measures.
No
significant
observed
overall
analysis.
However,
subgroup
analysis
revealed
increased
susceptibility
respiratory,
digestive,
reproductive
while
reducing
risk
after
excluding
cancers.
showed
protective
digestive
not
significantly
associated
specific
subtypes,
particularly
respiratory
These
findings
underscore
importance
genetic
environmental
factors
warrant
further
investigation.
Язык: Английский
M2 macrophage-derived exosomes reverse TGF-β1-induced epithelial mesenchymal transformation in BEAS-2B cells via the TGF-βRI/Smad2/3 signaling pathway
European journal of medical research,
Год журнала:
2025,
Номер
30(1)
Опубликована: Апрель 11, 2025
Airway
remodeling
in
bronchial
asthma
can
be
inhibited
by
disrupting
the
epithelial
mesenchymal
transition
(EMT)
of
activated
airway
cells.
Exosomes,
as
key
mediators
intercellular
communication,
have
been
implicated
pathophysiology
asthma-related
inflammation,
remodeling,
and
hyperresponsiveness.
This
study
aimed
to
investigate
role
M2
macrophage-derived
exosomes
(M2φ-exos)
modulating
TGF-β1-induced
EMT
(BEAS-2B)
cells
elucidate
underlying
molecular
mechanism,
if
any.
THP-1
were
induced
differentiate
into
macrophages
via
phorbol
12-myristate
13-acetate
(PMA)
IL-4.
Exosomes
subsequently
isolated
purified
ultracentrifugation.
M2φ-exos
expression
was
characterized
protein
marker
levels,
transmission
electron
microscopy
imaging,
nanoparticle
tracking
analysis.
BEAS-2B
exposed
determine
latter's
effects.
successfully
differentiated
macrophages,
confirmed
vitro
flow
cytometry.
The
presented
typical
cup-shaped
structures
expressed
CD81
TSG101.
TGF-β1
induction
altered
morphological
characteristics
TGF-βRI/Smad2/3
signaling
pathway,
leading
increased
Snail,
Vimentin
Collagen
1
decreased
E-cadherin.
After
exosome
or
SB431542
induction,
reversed.
GW4869,
an
release
inhibitor,
exhibited
ability
block
beneficial
effects
exosomes.
M2Φ-exos
through
pathway.
novel
insight
may
important
implications
for
asthma,
particularly
addressing
remodeling.
Язык: Английский