Immunological dimensions of neuroinflammation and microglial activation: exploring innovative immunomodulatory approaches to mitigate neuroinflammatory progression
Frontiers in Immunology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 8, 2024
The
increasing
life
expectancy
has
led
to
a
higher
incidence
of
age-related
neurodegenerative
conditions.
Within
this
framework,
neuroinflammation
emerges
as
significant
contributing
factor.
It
involves
the
activation
microglia
and
astrocytes,
leading
release
pro-inflammatory
cytokines
chemokines
infiltration
peripheral
leukocytes
into
central
nervous
system
(CNS).
These
instances
result
in
neuronal
damage
neurodegeneration
through
activated
nucleotide-binding
domain
leucine-rich
repeat
containing
(NLR)
family
pyrin
protein
3
(NLRP3)
nuclear
factor
kappa
B
(NF-kB)
pathways
decreased
erythroid
2-related
2
(Nrf2)
activity.
Due
limited
effectiveness
regarding
inhibition
neuroinflammatory
targets
using
conventional
drugs,
there
is
challenging
growth
search
for
innovative
therapies
alleviating
CNS
diseases
or
even
before
their
onset.
Our
results
indicate
that
interventions
focusing
on
Interleukin-Driven
Immunomodulation,
Chemokine
(CXC)
Receptor
Signaling
Expression,
Cold
Exposure,
Fibrin-Targeted
strategies
significantly
promise
mitigate
processes.
approaches
demonstrate
potential
anti-neuroinflammatory
effects,
addressing
conditions
such
Multiple
Sclerosis,
Experimental
autoimmune
encephalomyelitis,
Parkinson’s
Disease,
Alzheimer’s
Disease.
While
findings
are
promising,
immunomodulatory
often
face
limitations
due
Immune-Related
Adverse
Events.
Therefore,
conduction
randomized
clinical
trials
matter
mandatory,
will
pave
way
promising
future
development
new
medicines
with
specific
therapeutic
targets.
Язык: Английский
Design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti-inflammatory activities
Frontiers in Chemistry,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 21, 2025
Tumours
and
inflammation
are
serious
risks
to
human
health
importantly
regulated
by
the
gas
signalling
molecule
hydrogen
sulphide.
In
this
work,
we
report
rational
design
synthesis
of
H
2
S
donor
molecules
based
on
phenylthiophosphoryl
dichloride
nuclei
assess
their
efficacy
against
tumours
inflammation.
We
predicted
its
potential
anticancer
targets
network
pharmacology
then
verified
inhibitory
effect
active
compound
S11
pathway
PI3K/AKT
enzyme
inhibition
molecular
docking
assay.
addition,
exhibited
a
potent
anti-inflammatory
macrophages,
effectively
reducing
levels
inflammatory
mediators
TNF-α,
IL-10
HO-1.
Compound
can
be
used
as
new
chemical
entity
for
discovery
anti-cancer
drugs
or
drugs.
Язык: Английский
Schisandra chinensis (Turcz.) Baill neutral polysaccharides alleviate Parkinson's disease via effectively activating MCL-1 expression regulation of autophagy signaling
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
279, С. 134952 - 134952
Опубликована: Авг. 26, 2024
Язык: Английский
Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature
Pharmaceuticals,
Год журнала:
2025,
Номер
18(1), С. 133 - 133
Опубликована: Янв. 20, 2025
Neuroinflammation
is
a
key
factor
in
the
progression
of
neurodegenerative
diseases,
driven
by
dysregulation
molecular
pathways
and
activation
brain’s
immune
system,
resulting
release
pro-inflammatory
oxidative
molecules.
This
chronic
inflammation
exacerbated
peripheral
leukocyte
infiltration
into
central
nervous
system.
Medicinal
plants,
with
their
historical
use
traditional
medicine,
have
emerged
as
promising
candidates
to
mitigate
neuroinflammation
offer
sustainable
alternative
for
addressing
conditions
green
healthcare
framework.
review
evaluates
effects
medicinal
plants
on
neuroinflammation,
emphasizing
mechanisms
action,
effective
dosages,
clinical
implications,
based
systematic
search
databases
such
PubMed,
SCOPUS,
Web
Science.
The
findings
highlight
that
like
Cleistocalyx
nervosum
var.
paniala,
Curcuma
longa,
Cannabis
sativa,
Dioscorea
nipponica
reduce
cytokines
(TNF-α,
IL-6,
IL-1β),
inhibit
enzymes
(COX-2
iNOS),
activate
antioxidant
pathways,
particularly
Nrf2.
NF-κB
primary
pathway
inhibited
across
studies.
While
anti-inflammatory
potential
these
significant,
variability
dosages
phytochemical
compositions
limits
translation.
Here,
we
are
modulators
underscoring
therapeutic
potential.
Future
research
should
focus
animal
models,
standardized
protocols,
safety
assessments,
integrating
advanced
methodologies,
genetic
studies
nanotechnology,
enhance
applicability
disease
management.
Язык: Английский
Differentiation and regulation of CD4+ T cell subsets in Parkinson’s disease
Cellular and Molecular Life Sciences,
Год журнала:
2024,
Номер
81(1)
Опубликована: Авг. 17, 2024
Parkinson's
disease
(PD)
is
the
second
most
common
neurodegenerative
disease,
and
its
hallmark
pathological
features
are
loss
of
dopaminergic
(DA)
neurons
in
midbrain
substantia
nigra
pars
compacta
(SNpc)
accumulation
alpha-synuclein
(α-syn).
It
has
been
shown
that
integrity
blood-brain
barrier
(BBB)
damaged
PD
patients,
a
large
number
infiltrating
T
cells
inflammatory
cytokines
have
detected
cerebrospinal
fluid
(CSF)
brain
parenchyma
patients
animal
models,
including
significant
change
proportion
different
CD4
Язык: Английский
Clinical efficacy of integrated traditional Chinese and western medicine in the treatment of oligoasthenospermia in male infertility of kidney-yang deficiency type
Journal of Men s Health,
Год журнала:
2023,
Номер
19(12), С. 99 - 99
Опубликована: Янв. 1, 2023
This
study
examines
the
clinically
comprehensive
effects
of
Wuzi
Shenqi
Decoction,
an
acupoint
application
that
combines
traditional
Chinese
medicine
with
western
on
male
infertility
oligoasthenospermia
kidney-yang
deficiency
type.A
total
184
infertiles
who
came
to
our
hospital
from
April
2022
June
2023
were
randomly
assigned
a
group
(n
=
92)
and
experimental
92).The
was
treated
L-carnitine
oral
solution,
while
Decoction
combined
based
group.Before
after
treatment,
clinical
efficacy,
semen
parameters
(semen
volume,
sperm
density,
survival
rate,
motility),
sexual
hormone
(follicle
stimulating
(FSH),
luteinizing
(LH),
testosterone
(T),
prolactin
(PRL),
estradiol),
TCM
(Traditional
Medicine)
syndrome
scores
observed
compared
between
both
groups.Before
there
no
significant
difference
in
parameter
index,
index
score
groups
(p
>
0.05);
higher
than
before
diminished
<
0.05).The
overall
response
rate
92.39%,
which
significantly
(72.83%)
0.05).For
patients
type,
use
plus
solution
can
effectively
improve
symptoms
patients,
quality,
regulate
sex
levels,
is
worthy
application.
Язык: Английский