Adenocarpine, Marmesin, and Lycocernuine from Ficus benjamina as Promising Inhibitors of Aldose Reductase in Diabetes: A Bioinformatics-Guided Approach

Applied Biochemistry and Biotechnology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Язык: Английский

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Computational Insights into the Inhibition of Cell Division in Staphylococcus aureus: Towards Novel Therapeutics

Computational Biology and Chemistry, Год журнала: 2025, Номер 117, С. 108391 - 108391

Опубликована: Фев. 26, 2025

Язык: Английский

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Identification of Potential Anticancer Phytochemicals of Piper chaba by Comprehensive Molecular Docking, Molecular Dynamics Simulation and In‐Vitro Studies

Chemistry & Biodiversity, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

ABSTRACT Human colon cancer and prostate are the most common malignancy globally. Despite availability of many treatments, resistance to traditional medicines, such as chemotherapy radiotherapy, remains a severe obstacle in treatment. Hence, searching for new therapeutic options is utmost priority. The present investigation evaluates in‐silico in‐vitro anticancer potential phytochemicals Piper chaba . cytotoxicity results demonstrated that plant extract exhibited significant activity, with IC 50 values 12.66 ± 0.25 µg/mL HCT‐116 19.49 0.37 DU‐145. Molecular docking molecular dynamics simulations were performed explore interaction drug targets phytochemicals. Subsequently, pharmacokinetic parameters calculations evaluate drug‐likeness. Piperine exhibits highest binding affinity vascular endothelial growth factor receptor‐2 (VEGFR2) protein score −9.71 kcal/mol. Sylvatine had greater human epidermal receptor 3 (HER3) than other Isopiperine, chabamide, Piperlonguminine, Santamarine Versalide only ligand activity IKK beta (inhibitor kappa B kinase). Additionally, principal component analysis was strengthen investigation's scope. These proposed reported possess VEGFR2, HER2 inhibition. best phytochemical hits have excellent hold massive potential, opening up avenues prospective future investigations

Язык: Английский

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Carvacrol Effectively Inhibits Pseudomonas tolaasii In Vitro and Induces Resistance to Brown Blotch Disease in Postharvest Agaricus bisporus

Foods, Год журнала: 2024, Номер 13(22), С. 3689 - 3689

Опубликована: Ноя. 19, 2024

Carvacrol (CAR), a naturally occurring phenolic monoterpene compound, has recently received attention for its potential use in food preservation. However, whether it is effective controlling brown blotch disease caused by

Язык: Английский

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