Novel furazanoazepines derivatives as SDH inhibitors: Design, synthesis and their fungicidal activities

Bioorganic Chemistry, Год журнала: 2025, Номер 157, С. 108244 - 108244

Опубликована: Фев. 4, 2025

Язык: Английский

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Evaluation of Novel Pyridine-Based Compounds Integrating Bioactive Amide and Hydrazide Groups as a Potential Fungicide Agent

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

A series of novel pyridine-based compounds integrating bioactive amide and hydrazide groups were designed synthesized through an active group splicing strategy. The fungicidal bioassays indicated that several showed remarkable broad-spectrum inhibitory activity. Notably, compound A5 displayed satisfactory in vitro activity against Fusarium graminearum, Magnaporthe oryzae, Rhizoctonia solani, Colletotrichum gloeosporioides, Botrytis cinerea, Sclerotinia sclerotiorum, Alternaria sp., Physalospora piricola, with EC50 values 2.53, 2.84, 1.64, 7.59, 4.67, 5.50, 2.84 μg mL-1, respectively. Additionally, also promising vivo preventive efficiency F. graminearum R. solani at 100 mL-1. Preliminary investigation the mechanism demonstrated differentially expressed genes differential metabolites treated 10 mL-1 exhibited notable enrichment pathways associated lipid metabolism, potentially linking to plasma membrane contraction observed by TEM. Furthermore, assess environmental compatibility A5, its toxicity zebrafish, hydrolysis rates different pH buffers, effects on growth wheat seedlings evaluated. These findings will provide substantial theoretical guidance for development new environmentally friendly fungicides.

Язык: Английский

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Design, Synthesis, and Antifungal activity of N'-Phenylnicotinohydrazide Derivatives as Promising Fungicide Candidates against Phytopathogenic Fungi

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141982 - 141982

Опубликована: Март 1, 2025

Язык: Английский

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Design, Synthesis, and Antimicrobial Activity of Amide Derivatives Containing Cyclopropane

Molecules, Год журнала: 2024, Номер 29(17), С. 4124 - 4124

Опубликована: Авг. 30, 2024

As an important small organic molecule, cyclopropane is widely used in drug design. In this paper, fifty-three amide derivatives containing were designed and synthesized by introducing groups aryl into through the active splicing method, their antibacterial antifungal activities evaluated vitro. Among them, thirty-five compounds new compounds, eighteen known (F14, F15, F18, F20–F26, F36, F38–F44). Bioassay results disclosed that four, three, nine of showed moderate activity against Staphylococcus aureus, Escherichia coli, Candida albicans, respectively. Three sensitive to with excellent (MIC80 = 16 μg/mL). The molecular docking show F8, F24, F42 have good affinity potential target CYP51 protein.

Язык: Английский

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Interface-driven structural evolution on diltiazem as novel uPAR inhibitors: from in silico design to in vitro evaluation

Molecular Diversity, Год журнала: 2024, Номер unknown

Опубликована: Июнь 27, 2024

Язык: Английский

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Design, synthesis, antifungal, and antibacterial evaluation of ferulic acid derivatives bearing amide moiety

Molecular Diversity, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

Язык: Английский

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Design, synthesis, bioactivity and action mechanism of N-substituted N′-phenylpicolinohydrazides against phytopathogenic fungi

Molecular Diversity, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

Язык: Английский

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