Applied Sciences,
Год журнала:
2023,
Номер
13(22), С. 12348 - 12348
Опубликована: Ноя. 15, 2023
Food,
not
nutrients,
is
the
fundamental
unit
in
nutrition,
and
edible
mushrooms
are
fungi
that
supply
unique
biological
bioactive
compounds,
different
from
plant
or
animal
origin,
which
significantly
impact
human
health
status.
However,
to
date
all
these
concepts
interpreted
ways,
with
rapidly
increasing
knowledge
on
medicine,
molecular
biology,
biotechnology
changing
of
food,
health,
agriculture.
The
elements
conveyed
by
foodstuffs
as
nutrients
non-nutrients
interfere
metabolism
have
influence
aging,
well-being.
medicinal
interventions
has
been
known
studied
for
many
years
their
latest
role
neurodegenerative
disorders
recently
investigated,
while
significance
other
diseases
well
demonstrated.
Despite
considerable
research,
etiology
pathogenesis
Ménière’s
disease
remains
controversial
undefined,
although
usually
associated
allergic,
genetic,
trauma
sources,
viral
infections
and/or
immune
system-mediated
mechanisms.
With
treatment
still
unknown,
our
attention
towards
eventual
complementary
dietary
interventions,
synthesizing
recent
some
preparations
disease,
a
lifelong
condition
can
develop
at
any
age,
but
most
commonly
emerges
between
40
60
age.
It
demonstrated
oral
administration
biomass
preparation,
3
g/day
mushroom
Coriolus
versicolor
2
6
months,
patients
reduced
systemic
oxidative
stress
cellular
response,
decreased
number
crises
duration,
frequency
symptoms,
improving
clinical
grading
tinnitus
severity.
Nutraceuticals
comprise
dietary
supplements,
functional
foods,
medicinal
and
pharmaceuticals.
However,
to
date
all
these
concepts
are
interpreted
in
different
ways
with
the
rapid
increasing
knowledge
on
nutrition,
medicine,
plant
biotechnology
changing
about
food,
health
agriculture.
What
matters
bioactive
elements
conveyed
by
foodstuffs
as
nutrients
or
non-nutrients,
which
interfere
human
metabolism
have
impact
health,
aging
well-being.
Food,
not
nutrients,
is
fundamental
unit
nutrition
edible
mushrooms,
fungi
that
supply
unique
biological
compounds,
from
animal
origin,
significantly
status.
Their
influence
interventions
has
been
known
studied
for
many
years.
The
role
neurodegenerative
disorders
recently
investigated
their
significance
other
diseases
well
demonstrated.
On
this
note
it
synthesized
more
recent
of
some
mushrooms
preparations
Ménière’s
disease,
a
lifelong
condition
can
develop
at
any
age,
but
most
commonly
appearing
between
40
60
years
age.
Research Results in Pharmacology,
Год журнала:
2023,
Номер
9(3), С. 27 - 39
Опубликована: Сен. 20, 2023
Introduction:
The
therapeutic
effect
of
commercially
available
domestic
and
foreign
drugs
for
the
treatment
various
skin
injuries
is
far
from
optimal.
These
have
no
universal
effects,
but
cause
pronounced
side
reactions.
There
a
clear
demand
development
innovative
wound-healing
with
antimicrobial
properties,
which
increase
natural
protective
function
skin.
Pharmaceutical
compounds
zinc
nanoparticles
been
increasingly
recognized
as
promising
direction.
can
easily
penetrate
into
damaged
tissues
stimulate
metabolic
processes.
Zinc
complexes
imidazole
derivatives
are
particular
interest.
Imidazole
acts
structural
fragment
many
physiologically
active
compounds,
thus
providing
targeted
delivery
this
essential
trace
element
wound
inclusion
in
multicascade
mechanism
healing.
aim
study:
to
provide
experimental
evidence
effects
recently
developed
N-alkenylimidazole
healing
agents.
Materials
Methods:
Wound-healing
six
1%
gels
containing
distinct
complexe
based
on
Na-carboxymethylcellulose
(Na-CMC)
were
comparatively
studied
128
outbred
white
rats
both
genders.
Na-CMC-based
Sulfate
gel,
Methyluracil
Solcoseryl
served
reference
drugs.
After
performing
local
tolerance
study
complexes,
linear
planar
sterile
wounds
comparable
size
inflicted
anesthetized
animals.
degree
was
evaluated
day
8
28
after
start
by
sizes
histological
examination
inflammatory
response,
epithelization,
granulation
tissue,
angiogenesis,
necrosis.
microcirculation
system
using
laser
Doppler
Flowmetry
(LDF),
whereby
blood
flow
indicators
recorded
30
60
minutes
intraperitoneal
administration
trial
compound.
activity
determined
vitro
means
their
minimum
inhibitory
concentration
suppressing
bacteria
fungi
growth
double
serial
dilution
method
liquid
culture
media.
statistical
data
processing
performed
Statistica
12
software
package.
Results
Discussion:
In
model,
all
animals
treated
either
showed
almost
complete
reduction
(92-100%,
p<0.05)
8,
significantly
exceeding
control
(reduction
67-88
%,
83-86%,
p<0.05).
most
significant
reached
gel
N-isopropenylimidazole
diacetate
(encoded
Pilim-1).
respective
signs
epithelialization,
absence
destructive
changes
epidermis,
restoration
appendages
presence
mature
tissue.
Intraperitoneal
Pilim-1
at
dose
20
mg/kg
improved
rat
skin,
judged
perfusion
amplitudes
isolated
rhythms
LDF-gram.
addition,
exerted
moderate
bacteriostatic
fungistatic
activity,
2
times
greater
than
Metronidazole.
Conclusion:
Topical
application
complex
accelerates
uninfected
comparison
established
compound
exhibited
effect.
observed
action
further
interest
potential
implications
infected
wounds.
regenerative
substance
opens
prospects
new
properties.
Applied Sciences,
Год журнала:
2023,
Номер
13(22), С. 12348 - 12348
Опубликована: Ноя. 15, 2023
Food,
not
nutrients,
is
the
fundamental
unit
in
nutrition,
and
edible
mushrooms
are
fungi
that
supply
unique
biological
bioactive
compounds,
different
from
plant
or
animal
origin,
which
significantly
impact
human
health
status.
However,
to
date
all
these
concepts
interpreted
ways,
with
rapidly
increasing
knowledge
on
medicine,
molecular
biology,
biotechnology
changing
of
food,
health,
agriculture.
The
elements
conveyed
by
foodstuffs
as
nutrients
non-nutrients
interfere
metabolism
have
influence
aging,
well-being.
medicinal
interventions
has
been
known
studied
for
many
years
their
latest
role
neurodegenerative
disorders
recently
investigated,
while
significance
other
diseases
well
demonstrated.
Despite
considerable
research,
etiology
pathogenesis
Ménière’s
disease
remains
controversial
undefined,
although
usually
associated
allergic,
genetic,
trauma
sources,
viral
infections
and/or
immune
system-mediated
mechanisms.
With
treatment
still
unknown,
our
attention
towards
eventual
complementary
dietary
interventions,
synthesizing
recent
some
preparations
disease,
a
lifelong
condition
can
develop
at
any
age,
but
most
commonly
emerges
between
40
60
age.
It
demonstrated
oral
administration
biomass
preparation,
3
g/day
mushroom
Coriolus
versicolor
2
6
months,
patients
reduced
systemic
oxidative
stress
cellular
response,
decreased
number
crises
duration,
frequency
symptoms,
improving
clinical
grading
tinnitus
severity.
