Immune Cell Migration to Cancer

Cells, Год журнала: 2024, Номер 13(10), С. 844 - 844

Опубликована: Май 16, 2024

Immune cell migration is required for the development of an effective and robust immune response. This elegant process regulated by both cellular environmental factors, with variables such as state, anatomical location, disease state that govern differences in patterns. In all cases, a major factor expression surface receptors their cognate ligands. Rapid adaptation to conditions partly depends on intrinsic factors affect cell’s ability adjust new environment. this review, we discuss myeloid lymphoid cells outline key determinants migration, including molecules adhesion, modes chemotaxis, specific chemokine signaling. Furthermore, summarize tumor-specific elements contribute trafficking cancer, while also exploring microenvironment can alter these dynamics within tumor pro antitumor fashion. Specifically, highlight importance secretome later aspects. review considers myriad impact trajectory cancer. We aim immunotherapeutic targets be harnessed achieve controlled tumors.

Язык: Английский

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Outside-in engineering of cadherin endocytosis using a conformation strengthening antibody

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 29, 2025

Abstract P-cadherin, a crucial cell-cell adhesion protein which is overexpressed in numerous malignant cancers, popular target for drug delivery antibodies. However, molecular guidelines engineering antibodies that can be internalized upon binding to P-cadherin are unknown. Here, we use combination of biophysical, biochemical, and cell biological methods demonstrate trapping the extracellular region an X-dimer adhesive conformation triggers cadherin endocytosis via outside-in signaling mechanism. We show anti-cancer monoclonal antibody CQY684, traps strengthens this structure. Formation stable X-dimers results phosphorylation p120-catenin, suppressor endocytosis. This dissociation p120-catenin from cytoplasmic region, increases turnover targets cadherin-antibody complex lysosome. Our establish mechanism provides fundamental insights into how cells regulate exploited by anti-cadherin intracellular delivery.

Язык: Английский

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Peptide-driven strategies against lung cancer

Life Sciences, Год журнала: 2025, Номер unknown, С. 123453 - 123453

Опубликована: Фев. 1, 2025

Язык: Английский

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Brazil nut (Bertholletia excelsa Bonpl.) in health and disease: A narrative review

Food Chemistry, Год журнала: 2025, Номер unknown, С. 143425 - 143425

Опубликована: Фев. 1, 2025

Язык: Английский

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Exploring the therapeutic promise of fisetin: molecular mechanisms and clinical aspects in lung cancer

Journal of Complementary and Integrative Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Abstract Fisetin, a flavonol belonging to the flavonoid subclass, is ubiquitous dietary present in fruits and vegetables, including fruit peels, has proven potential for anticancer activity, especially lung cancer – leading cause of cancer-related deaths globally. The current paper provides most detailed elaborate list various roles fisetin experimentally induced cells, these include promotion apoptosis, inhibition cell proliferation, migration, invasion, as well regulation autophagy. Among molecular targets, some identified pathways, such PI3K/Akt, MAPK, NF-κB, that affects are crucial tumor formation, so it can be considered chemopreventive agent. Moreover, improves effectiveness conventional treatments chemo- radiosensitizer minimizes side effects. However, overall utility clinical use now somewhat restricted by its poor solubility short half-life. It predicted future development nanotechnologies drug delivery, nanoparticle encapsulation, might help solve difficulties. Further Preclinical investigations required uniformly determine safety, efficacy, standard dosage consumption therapy.

Язык: Английский

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Editorial: Molecular mechanisms and therapeutic targets of cancer metastasis and therapy resistance

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Март 5, 2025

from the primary tumor site to distant organs, where they form secondary foci.The occurrence of metastasis involves complex cellular signaling pathways and changes in microenvironment (1). Tumor resistance, especially chemotherapy, targeted therapy, immunotherapy, significantly impacts treatment efficacy, resulting recurrence cancer progression. To improve survival quality life patients, it is urgent understand molecular mechanisms drug resistance identify new therapeutic targets.Tumor a multi-step process, involving detachment cells, invasion, dissemination through blood or lymphatic systems, growth organs. Epithelial-Mesenchymal Transition (EMT) critical process which cells acquire invasive metastatic potential (2,3). The (e.g. cancer-associated fibroblasts, etc.) immune tumor-associated macrophages, also participate (4).Additionally, angiogenesis an important condition for metastasis. Deregulation Cuproptosis has been linked metastasis, recent review by Wang et al., unbalanced levels copper promote angiogenesis, enabling cell spread (Frontiers oncology. 2023;13:1288504.). Moreover, could degrade extracellular matrix secretion metalloproteinases other enzymes, creating conditions crossing tissue barriers (5). Some molecules are involved cells. Adhesion integrins, cadherins, etc.), factors cytokines epidermal factor, platelet-derived Wnt/βcatenin pathway, PI3K/Akt/mTOR pathway play key roles (6,7). Min al. recently reviewed impact adhesion-associated molecule Desmoglein-2 (DSG2) on adhesion, migration, vasculogenic mimicry. More importantly, proposed that pro-tumorigenic anti-tumorigenic function DSG2 context dependent 2023;13:1327478.).Tumor significant challenge treatment, as employ various render drugs ineffective reduce their efficacy. P-glycoprotein, multidrug resistance-associated proteins family, breast protein examples efflux pumps expel chemotherapy (8). Gene mutations including PIK3CA, KRAS, EGFR, p53 OCT4 have related phenotype (9). undergo metabolic reprogramming increasing antioxidant enhance (10,11). DNA methylation, histone modification noncoding RNAs regulation alter gene expression leading escaping drug-induced death (12). repair capabilities resist damage induced drugs. Kaljunen found inactivation Fanconi anemia reverse prostate during DNA-damaging line-specific manner 2023;13:1260826.). apoptotic would ability lead (13). stem small population within possess self-renewal multi-lineage differentiation capabilities, (14). High heterogeneity makes vary sensitivity with some potentially harboring genetic phenotypic features (15). Immune checkpoint inhibitors PD-1/PD-L1 nivolumab, pembrolizumab, system attack tumors, intensively investigated several cancers (17). Immunotherapy targeting specific antigens (e.g., HPV vaccines) boosts memory prevent (18). Taking into consideration, combining multiple approaches (such immunotherapy chemotherapy) become strategy. target different provide comprehensive against strategy.Tumor two major challenges treatment. Currently, progress made research targets resistance. In future, further needed discover more effective develop precise, efficient, low-toxicity strategies outcomes rates patients. Combination therapies, such therapies radiotherapy, may be direction overcome deserve in-depth exploration. Additionally, continuous development technologies CRISPR editing, single-cell sequencing), we expect obtain precise strategies. By continuously delving open up avenues, improving

Язык: Английский

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Bioactive bacterial cellulose/chitosan/sodium alginate composite film functionalized with Moringa oleifera seed extract: Antimicrobial, anticancer, and molecular docking studies

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141958 - 141958

Опубликована: Март 1, 2025

Язык: Английский

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Single cell analysis reveals that SPP1+ macrophages enhance tumor progression by triggering fibroblast extracellular vesicles

Translational Oncology, Год журнала: 2025, Номер 55, С. 102347 - 102347

Опубликована: Март 13, 2025

Язык: Английский

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Association between TGF-β1 and β-catenin expression in the vaginal wall of patients with pelvic organ prolapse

Open Life Sciences, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 1, 2025

Abstract The aim of this study is to investigate the mechanism action and correlation between transforming growth factor beta 1 (TGF-β1) β-catenin in pelvic organ prolapse (POP). compared vaginal wall tissues from two groups: 20 patients with POP (POP group) who had hysterectomies for benign conditions (control group). Hematoxylin Eosin Masson staining visualized collagen, while TUNEL detected apoptosis. Protein mRNA expression levels TGF-β1, β-catenin, matrix metallopeptidase 2 (MMP2), tissue inhibitor metalloproteinases (TIMP2), type I, alpha (COL1A1) were assessed using immunohistochemistry, quantitative real-time polymerase chain reaction, western blot techniques. Relationships protein expressions TGF-β1 COL1A1, COL1A1 analyzed. In group, collagen fibers sparse, disorganized, fragmented, fewer more apoptotic cells control group. TIMP2, significantly lower, MMP2 was higher ( p < 0.05). Positive correlations found COL1A1. Reduced may trigger by affecting floor metabolism.

Язык: Английский

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The Role of Connections Between Cellular and Tissue Mechanical Elements and the Importance of Applied Energy in Mechanotransduction in Cancerous Tissue

Biomolecules, Год журнала: 2025, Номер 15(4), С. 457 - 457

Опубликована: Март 21, 2025

In the presence of cellular mutations and impaired mechanisms energy transmission to attached cells tissues, excess is available upregulate some mechanotransduction pathways that maintain cell tissue structure function. The ability transfer applied through integrin-mediated pathways, ion channels, membrane, cytoskeleton–nucleoskeleton connections, junctions, cell–extracellular matrix attachments provides an equilibrium for storage, transmission, dissipation in tissues. Disruption or via genetic blocks mechanical communication between tissues impairs exists This results local structural changes altered regulatory which produce clustering, collagen encapsulation, epithelial–mesenchymal transition (EMT), leading increased motility along newly reorganized fibers (fibrosis). goal this review postulate how extracellular may alter pathways. with lead ECM reported cancer, postulated modify equilibria their ECM. leads uncontrolled cancer proliferation remodeling.

Язык: Английский

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