Pharmacological Research,
Год журнала:
2024,
Номер
210, С. 107502 - 107502
Опубликована: Ноя. 7, 2024
Cancer
continues
to
be
a
leading
cause
of
death
worldwide,
highlighting
the
urgent
need
for
development
new
therapeutic
strategies.
Chrysophanol,
naturally
occurring
anthraquinone
compound,
has
demonstrated
significant
potential
in
cancer
treatment
due
its
diverse
biological
activities.
This
review
delves
into
mechanisms
through
which
chrysophanol
exerts
anti-cancer
effects,
including
induction
cell
cycle
arrest,
promotion
apoptosis,
regulation
autophagy,
and
initiation
necrosis
across
various
lines.
Additionally,
discusses
chrysophanol's
impact
on
inhibiting
invasion
metastasis
role
modulating
chemotherapy
sensitivity.
Despite
promising
chrysophanol,
challenges
such
as
poor
water
solubility,
low
bioavailability,
safety
concerns
remain.
Comprehensive
clinical
trials
are
essential
validate
efficacy
safety.
emphasizes
candidate
therapy
underscores
necessity
further
research
fully
harness
potential.
Frontiers in Materials,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 9, 2025
Cancer
is
one
of
the
deadliest
diseases
despite
aggressive
therapeutics.
This
due
in
part
to
evolving
tumor
microenvironment
(TME),
which
provide
supportive
cues
that
promote
adaptation
and
progression.
Emerging
studies
highlight
significant
role
biophysical
characteristics
TME
modulating
all
aspects
cancer
spread.
With
advance
bioengineering
platforms,
deeper
investigations
into
impact
these
features
on
progression
are
being
conducted
with
a
growing
appreciation
intratumoral
compression
underlie
many
changes.
Intratumoral
emerges
early
development
increases
magnitude
as
rapidly
expands
against
itself
its
surrounding
tissue.
stress
has
effects
both
cells
TME,
including
hypoxia,
shear
stress,
extracellular
matrix
(ECM)
remodeling,
substrate
stiffness.
creates
physically
dense,
pro-malignant
environment
can
metastatic
phenotypes
spread
but
also
present
barriers
for
immune
cell
infiltration.
review
will
analyze
effect
compressive
cells,
confined
migration
populations.
Current Drug Targets,
Год журнала:
2024,
Номер
25(11), С. 740 - 751
Опубликована: Июль 11, 2024
Quercetin
is
a
natural
flavonoid
with
various
pharmacological
actions
such
as
anti-inflammatory,
antioxidant,
antimicrobial,
anticancer,
antiviral,
antidiabetic,
cardioprotective,
neuroprotective,
and
antiviral
activities.
Looking
at
these
enormous
potentials,
researchers
have
explored
how
they
can
be
used
to
manage
numerous
cancers.
It's
been
studied
for
cancer
management
due
its
anti-angiogenesis,
anti-metastatic,
antiproliferative
mechanisms.
Despite
having
proven
activities,
the
clinical
use
of
quercetin
limited
first--
pass
metabolism,
poor
solubility,
bioavailability.
To
address
shortcomings,
fabricated
nanocarriers-based
formulations
fight
cancer.
The
present
review
overshadows
potential,
mechanisms,
application
nanoformulations
against
different
Teaser:
Explore
potential
Quercetin,
diverse
in
managing
Translational Lung Cancer Research,
Год журнала:
2024,
Номер
13(7), С. 1450 - 1462
Опубликована: Июль 1, 2024
Spread
through
air
spaces
(STAS)
is
one
of
the
multiple
modes
lung
cancer
dissemination,
yet
its
molecular
and
clinicopathological
characterization
remains
poorly
studied.
This
study
aimed
to
investigate
effect
adhesion
molecule
expression
levels
on
incidence
STAS
postoperative
recurrence
in
stage
I
patients
undergoing
radical
resection.
Journal of Cell Science,
Год журнала:
2024,
Номер
137(10)
Опубликована: Май 15, 2024
ABSTRACT
Membrane
trafficking,
a
fundamental
cellular
process
encompassing
the
transport
of
molecules
to
specific
organelles,
endocytosis
at
plasma
membrane
and
protein
secretion,
is
crucial
for
homeostasis
signalling.
Cancer
cells
adapt
trafficking
enhance
their
survival
metabolism,
understanding
these
adaptations
vital
improving
patient
responses
therapy
identifying
therapeutic
targets.
In
this
Review,
we
provide
concise
overview
major
pathways
detail
in
pathways,
including
COPII-dependent
endoplasmic
reticulum
(ER)-to-Golgi
vesicle
COPI-dependent
retrograde
Golgi-to-ER
endocytosis,
that
have
been
found
cancer.
We
explore
how
confer
growth
advantages
or
resistance
cell
death
conclude
by
discussing
potential
utilising
knowledge
developing
new
treatment
strategies
overcoming
drug
cancer
patients.
Pharmaceutical Science Advances,
Год журнала:
2024,
Номер
2, С. 100046 - 100046
Опубликована: Июль 2, 2024
Patients
with
advanced
hepatocellular
carcinoma
(HCC)
are
not
sensitive
to
sorafenib
(SOR),
therefore,
combination
therapy
is
required.
In
this
study,
an
improved
thin-film
dispersion
and
post-insertion
anchoring
technique
was
utilized
construct
a
dual-targeted
co-delivery
SOR
docetaxel
(DTX)
liposome
drug
delivery
system,
folate/chondroitin
sulfate
SOR/DTX-modified
liposomes
(FA/CS@SDLP),
jointly
enhance
the
anti-recurrence
metastasis
of
HCC.
FA/CS@SDLP
can
establish
gradual
release
two
drugs
because
successful
lysosomal
escape
in
condensed
hyaluronidase
environment.
The
results
indicated
that
modification
folate
(FA)
chondroitin
(CS)
significantly
enhanced
cellular
uptake
internalization
SOR/DTX
HepG2
cells
through
FA
CD44
receptor-mediated
endocytosis.
Compared
free
or
mono-targeted
liposomal
system
(FA@SDLP),
presented
higher
potency
against
regarding
pro-apoptosis,
anti-proliferation,
anti-metastasis
(migration
invasion).
Moreover,
more
satisfactory
antitumor
efficacy
observed
for
pulmonary
HCC
mouse
model.
summary,
synergistically
treat
recurrence
metastasis,
providing
new
approach
clinically
accurate
treatment
Pharmaceutics,
Год журнала:
2024,
Номер
17(1), С. 2 - 2
Опубликована: Дек. 24, 2024
Background/Objectives:
Averrhoa
carambola,
or
star
fruit,
is
a
shrub
known
for
its
medicinal
properties,
especially
due
to
bioactive
metabolites
identified
in
roots
and
fruit
with
anti-cancer
activity.
However,
the
biological
effects
of
leaves
remain
unexplored.
This
study
aimed
assess
ethanolic
extract
from
A.
carambola
on
triple-negative
breast
cancer
(TNBC),
an
aggressive
subtype
lacking
specific
therapy.
Methods:
Phytochemical
analysis
HPLC
profile
additional
cell
line
evaluation
employing
MDA-MB-231
were
carried
out.
Results:
screening
revealed
that
was
rich
flavonoids,
saponins,
steroids,
demonstrating
antioxidant
capacity
45%.
1H
NMR
indicated
presence
terpenes,
glycoside-like
compounds.
Cell
viability
assays
showed
concentration-dependent
decrease
viability,
IC50
value
20.89
μg/mL
at
48
h.
Clonogenic
significant
inhibition
replicative
immortality,
only
2.63%
survival
15
μg/mL.
Migration,
assessed
through
wound
healing
assay,
reduced
3.06%
100
μg/mL,
16.23%
cells
remaining
attached.
An
additive
effect
observed
when
combining
lower
concentrations
doxorubicin,
indicating
potential
synergy.
Conclusions:
These
results
suggest
contains
activity
against
TNBC
cells,
supporting
further
research
into
their
compounds
therapeutic
potential.
Translational Pediatrics,
Год журнала:
2024,
Номер
13(4), С. 596 - 609
Опубликована: Апрель 1, 2024
Background:
Infantile
fibrosarcoma
(IFS)
is
the
most
prevalent
soft
tissue
sarcoma
in
children
under
1
year
old
and
known
for
its
rapid
growth.
The
tumor
lacks
specific
immunohistochemical
marker
a
general
view
of
microenvironment
(TME).
Its
primary
therapeutic
intervention
places
patients
at
risk
disability
or
mutilation.
This
study
aimed
to
elucidate
universal
transcriptional
characteristics
IFS
explore
novel
targets
diagnosis
therapy
using
single-cell
RNA
sequencing
(scRNA-seq).
Methods:
Fresh
samples
scRNA-seq
were
collected
from
four
before
other
treatments
administered.
We
conducted
cell
clustering,
inferring
copy
number
variation
(InferCNV)
analysis,
gene
differential
expression
function
evaluation,
Pearson
correlation
cell-cell
ligand-receptor
interaction
analysis
investigate
distinct
ecosystem
IFS.
Results:
According
resolution
data,
we
depicted
atlas
IFS,
which
comprised
14
populations.
Through
comparison
with
normal
cells,
malignant
cells
distinguished,
potential
markers
(POSTN,
IGFBP2
CTHRC1)
identified.
also
found
various
functional
subtypes,
three
exhibited
cancer
stem
(CSCs)
phenotypes,
investigated
interplay
between
these
subtypes
nonmalignant
TME
Endothelial
macrophages
dominate
communication
landscape
within
microenvironment,
promoting
tumorigenesis
via
multiple
receptor-ligand
interactions.
Conclusions:
provides
comprehensive
characterization
transcriptome
cellular
level,
offering
valuable
insights
clinically
significant
advancements
treatment
Abstract
In
nature,
the
inherent
adaptability
and
responsiveness
of
proteins
play
a
crucial
role
in
survival
reproduction
organisms,
enabling
them
to
adjust
ever‐changing
environments.
A
comprehensive
understanding
protein
structure
function
is
essential
for
unraveling
complex
biological
adaptive
processes,
providing
new
insights
design
protein‐based
materials
advanced
fields.
Recently,
derived
from
with
specific
properties
functions
have
been
engineered.
These
materials,
distinguished
by
their
engineered
responsiveness,
range
nanoscale
macroscale
through
meticulous
control
structure.
First,
review
introduces
natural
encompassing
adhesion
responses
organisms
light,
magnetic
fields,
temperature.
Next,
it
discusses
achievements
protein‐engineered
assembly
nanotechnology,
emphasizing
precise
over
bioactivity.
Finally,
briefly
addresses
application
engineering
techniques
self‐assembly
capabilities
achieve
humidity,
magnetism,
temperature,
other
factors.
We
hope
this
will
foster
multidimensional
thereby
advancing
interdisciplinary
integration
biomedical
science,
biotechnology.
