International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142651 - 142651
Опубликована: Март 1, 2025
Язык: Английский
Discover Oncology, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 21, 2025
Abstract Cancer, one of the deadliest diseases, has remained epicenter biological research for more than seven decades. Yet all efforts a perfect therapeutic cure come with certain limitations. The use medicinal plants and their phytochemicals as therapeutics received much attention in recent years. Silymarin, polyphenolic flavonoid variety anti-cancerous properties, was isolated from plant Silybum marianum . present review centres on function silymarin controlling important signalling pathways related to apoptosis survival, such JAK/STAT pathway, PI3K/Akt/mTOR, Bcl-2/Bax, Fas/FasL. It is emphasised that silymarin's capacity target these key mechanism behind its anticancer effects against malignancies. By upregulating pro-apoptotic downregulating anti-apoptotic proteins, controls series events result tumor suppression cell death cancer types. low bioavailability limited efficacy are improved by application various nano-delivery systems. As efficient carriers, liposomes, polymeric micelles, lipid- metal-based nanoparticles, increase solubility distribution tissues. Lastly, number preclinical studies provide basis upcoming interventions highlighted review, providing encouraging directions additional advancement.
Язык: Английский
Процитировано
1
Molecules, Год журнала: 2024, Номер 29(15), С. 3538 - 3538
Опубликована: Июль 27, 2024
Cancer is the second leading cause of death in world following cardiovascular disease. Its treatment, including radiation therapy and surgical removal tumour, based on pharmacotherapy, which prompts a constant search for new more effective drugs. There are high costs associated with designing, synthesising, marketing substances. Drug repositioning an attractive solution. Fluoroquinolones make up group synthetic antibiotics broad spectrum activity bacterial diseases. Moreover, those compounds particular interest to researchers as result reports their antiproliferative effects cells most lethal cancers. This article presents current progress development fluoroquinolone derivatives potential anticancer cytotoxic activity, well structure-activity relationships, along possible directions further development.
Язык: Английский
Процитировано
7
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Июль 11, 2024
Silybum marianum (L.) Gaertn, a herbaceous plant with long history in traditional medicine for the treatment of hepatobiliary diseases, particularly Europe, which has attracted attention its remarkable therapeutic effect. This review systematically summarizes research progress botany, phytochemistry, pharmacology, comprehensive utilization and synthetic biology S . Up to now, more than 20 types flavonolignan components have been isolated from In addition, rearch on fatty acids triterpenoids is also constantly improving. Among them, silybin most active compound flavonolignans components. Its pharmacological effects vivo vitro include anti-inflammatory, antioxidant, anti-tumour, hypoglycaemic, neuroprotective immunoregulatory properties. The use coniferyl alcohol taxifolin as substrates produce isosilybin under action enzyme catalysis commonly used biosynthetic pathway silymarin, provides support analysis silymarin. addition medicinal use, extracts plants broad application prospects production food, healthcare products, cosmetics other aspects. chemical composition, mechanism S. need be further studied, very important clinical efficacy resource development.
Язык: Английский
Процитировано
6
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142651 - 142651
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0