Therapeutic potential of morin hydrate in methotrexate-induced liver in experimental rats: regulation of organ function and alleviation of oxidative stress

Çukurova medical journal (Online)/Çukurova medical journal, Год журнала: 2025, Номер 50(1), С. 211 - 220

Опубликована: Март 25, 2025

Purpose: Methotrexate (MTX) is an antineoplastic agent with a wide clinical use. However, its complications in tissues cause limitations. The effects of many compounds have been studied reducing the toxicity MTX liver tissue. There are limited studies on elimination this damage morin hydrate (MH) flavonoid. In study, we investigated effect MH MTX-induced hepatoxicity focus oxidative stress. Materials and Methods: experiment, 32 female rats were grouped as Control, MTX, MH, MTX+MH (n=8). On first day 20 mg/kg single dose was administered ip. 100 by gavage for 10 days. 11th day, biochemical histopathological analyses performed from rats. All data presented statistical comparison. Results: Serum AST, ALT LDH levels highest group lower group. increased glutathione peroxidase (GPX), reduced (GSH) total antioxidant capacity (TAC) levels, but had no regulatory superoxide dismutase (SOD) level. Additionally, significantly lowered malondialdehyde (MDA) oxidant (TOC). Histopathological findings included inflammation, congestion, degeneration, mononuclear cell clusters dead cells. Tissue most severe group, whereas these attenuated Conclusion: Our results indicated that may be potential therapeutic acute injury.

Язык: Английский

---

Comparative expression and localization of visfatin, chemerin, and chemerin receptor proteins in a heat-stressed mouse testis

Tissue and Cell, Год журнала: 2024, Номер 88, С. 102374 - 102374

Опубликована: Апрель 6, 2024

Язык: Английский

---

Exploring the mechanism of carbamazepine decreasing testosterone levels based on cAMP/PKA/CREB pathway

3 Biotech, Год журнала: 2024, Номер 14(12)

Опубликована: Ноя. 19, 2024

Язык: Английский

---

Ellagic acid mitigates heat-induced testicular detriment in a mouse model

The Journal of Steroid Biochemistry and Molecular Biology, Год журнала: 2024, Номер 243, С. 106576 - 106576

Опубликована: Июль 9, 2024

Язык: Английский

---