Abstract
Background
Dental
pathogens
play
a
crucial
role
in
oral
health
issues,
including
tooth
decay,
gum
disease,
and
infections,
recent
research
suggests
link
between
these
cancer
initiation
progression.
Innovative
therapeutic
approaches
are
needed
due
to
antibiotic
resistance
concerns
treatment
limitations.
Methods
We
synthesized
analyzed
piperine-coated
zinc
oxide
nanoparticles
(ZnO-PIP
NPs)
using
UV
spectroscopy,
SEM,
XRD,
FTIR,
EDAX.
Antioxidant
antimicrobial
effectiveness
were
evaluated
through
DPPH,
ABTS,
MIC
assays,
while
the
anticancer
properties
assessed
on
KB
squamous
carcinoma
cells.
Results
ZnO-PIP
NPs
exhibited
significant
antioxidant
activity
of
50
µg/mL
against
dental
pathogens,
indicating
strong
properties.
Interaction
analysis
revealed
high
binding
affinity
with
pathogens.
showed
dose-dependent
cells,
upregulating
apoptotic
genes
BCL2,
BAX,
P53.
Conclusions
This
approach
offers
multifaceted
solution
combatting
both
infections
cancer,
showcasing
their
potential
for
advancement
healthcare.
It
is
essential
acknowledge
limitations
challenges
associated
use
ZnO
clinical
applications.
These
may
include
regarding
nanoparticle
toxicity,
biocompatibility,
long-term
safety.
Further
rigorous
testing
warranted
address
issues
ensure
safe
effective
translation
into
practice.
Inflammopharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Across
diverse
cultures,
herbal
remedies
have
been
used
to
alleviate
oral
discomfort
and
maintain
dental
hygiene.
This
review
presents
studies
on
with
remarkable
antimicrobial,
anti-inflammatory,
antioxidant,
anticancer,
anticaries,
analgesic,
healing
properties.
The
manuscripts
demonstrate
the
depth
of
scientific
inquiry
into
for
management
various
health
conditions.
These
include
gingivitis,
ulcers,
mucositis,
periodontitis,
pathogens,
carcinoma,
xerostomia,
caries.
Researchers
investigated
phytochemical
pharmacological
properties
plant-derived
compounds
their
extracts
evaluated
interactions
pathogens
inflammatory
processes.
convergence
traditional
knowledge
rigorous
investigation
offers
a
compelling
narrative,
fostering
deeper
understanding
as
viable
alternatives
conventional
interventions.
work
has
potential
provide
patients
access
gentle,
yet
effective
solutions,
simultaneously
offer
professionals
opportunity
enrich
knowledge,
ability
personalized,
holistic
care.
highlights
symbiotic
relationship
between
medicine
understanding,
emphasizing
importance
disseminating
this
benefit
both
practitioners
patients,
enabling
evidence-based
decision-making
in
exploration
promising
alternative,
potentially
mitigating
some
these
side
effects
while
promoting
more
natural
manner.
Molecules,
Год журнала:
2024,
Номер
29(11), С. 2706 - 2706
Опубликована: Июнь 6, 2024
The
fabrication
of
zinc
oxide-based
nanomaterials
(including
natural
and
synthetic
polymers
like
sulfated
polysaccharide,
chitosan,
polymethyl
methacrylate)
has
potential
to
improve
oral
cancer
treatment
strategies.
This
comprehensive
review
explores
the
diverse
synthesis
methods
employed
fabricate
oxide
tailored
for
applications.
Several
processes,
particularly
sol–gel,
hydrothermal,
chemical
vapor
deposition
approaches,
are
thoroughly
studied,
highlighting
their
advantages
limitations.
also
examines
how
parameters,
such
as
precursor
selection,
reaction
temperature,
growth
conditions,
influence
both
physicochemical
attributes
biological
efficacy
resulting
nanomaterials.
Furthermore,
recent
advancements
in
surface
functionalization
modification
strategies
targeted
at
improving
targeting
specificity
pharmaceutical
effectiveness
therapy
elucidated.
Additionally,
provides
insights
into
existing
issues
prospective
views
field,
emphasizing
need
further
research
optimize
methodologies
elucidate
mechanisms
underlying
nanoparticles
therapy.
BioMedical Engineering OnLine,
Год журнала:
2024,
Номер
23(1)
Опубликована: Июль 25, 2024
Abstract
Nanotechnology
has
contributed
important
innovations
to
medicine
and
dentistry,
also
offered
various
applications
the
field
of
orthodontics.
Intraoral
appliances
must
function
in
a
complex
environment
that
includes
digestive
enzymes,
diverse
microbiome,
mechanical
stress,
fluctuations
pH
temperature.
can
improve
performance
orthodontic
brackets
archwires
by
reducing
friction,
inhibiting
bacterial
growth
biofilm
formation,
optimizing
tooth
remineralization,
improving
corrosion
resistance
biocompatibility
metal
substrates,
accelerating
or
decelerating
movement
through
application
novel
nanocoatings,
nanoelectromechanical
systems,
nanorobots.
This
comprehensive
review
systematically
explores
nanotechnology,
particularly
its
impacts
on
movement,
antibacterial
activity,
friction
reduction,
resistance.
A
search
across
PubMed,
Web
Science
Core
Collection,
Google
Scholar
yielded
261
papers,
which
28
met
our
inclusion
criteria.
These
selected
studies
highlight
significant
benefits
nanotechnology
devices.
Recent
clinical
trials
demonstrate
advancements
brought
may
facilitate
future
delivery
more
effective
comfortable
care.
Wound
healing
is
a
complex
physiological
process
essential
for
the
restoration
of
tissue
integrity
and
function.
Novel
therapeutic
approaches
are
urgently
needed
to
enhance
wound-healing
outcomes.
Nanotechnology,
particularly
zinc
oxide
nanoparticles,
has
shown
promise
due
its
antimicrobial,
anti-inflammatory,
regenerative
properties.
β-chitosan,
derived
from
squid
pens,
possesses
superior
solubility
bioactivity
compared
α-chitosan,
making
it
valuable
biomaterial
biomedical
applications.
Through
integration
β-chitosan
this
study
seeks
use
complementary
properties
both
substances
overcome
present
constraints
in
wound
care
treatments.
Artificial Cells Nanomedicine and Biotechnology,
Год журнала:
2024,
Номер
52(1), С. 512 - 528
Опубликована: Окт. 25, 2024
Oral
squamous
cell
carcinoma
(OSCC)
is
a
disease
of
significant
concern
with
higher
mortality
rates.
Conventional
treatment
approaches
have
several
drawbacks,
leading
to
the
opening
new
research
avenues
in
field
nanoparticle-based
cancer
therapeutics.
The
study
aimed
at
synthesis
gold
nanoparticles
(Pm-AuNPs)
from
aqueous
bark
extract
Pterocarpus
marsupium,
followed
by
its
characterization
and
vitro
anticancer
evaluation
against
OSCC.
synthesized
Pm-AuNPs
were
characterized
using
UV–visible
spectroscopy,
particle
size
analyser,
zeta
potential,
FTIR
SEM
techniques.
potential
was
evaluated
OSCC
lines
(SCC29b,
SSC154
OECM-1)
through
assays.
IC50
value
found
be
25
±
1.2,
45
1.5
75
2.1
µg/mL
for
three
lines,
elucidating
cytotoxic
effects
mechanism
action.
Intracellular
ROS
SOX
detection,
mitochondrial
transmembrane
analysis
apoptosis
detection
used
confirm
activity
Acute
toxicity
studies
on
Wistar
rats
confirmed
non-toxic
nature
dose
concentration
up
2000
mg/kg
body
weight.
findings
underscore
as
promising
candidates
future
therapeutics,
providing
insights
into
their
action
therapeutic
efficacy
