Tissue and Cell, Год журнала: 2024, Номер 93, С. 102687 - 102687
Опубликована: Дек. 18, 2024
Язык: Английский
Biomolecules, Год журнала: 2024, Номер 14(9), С. 1055 - 1055
Опубликована: Авг. 25, 2024
This comprehensive review investigates the pivotal role of reactive oxygen species (ROS) in cataract formation and evaluates potential antioxidant therapies mitigating this ocular condition. By elucidating mechanisms oxidative stress, article examines how ROS contribute to deterioration lens proteins lipids, leading characteristic aggregation, cross-linking, light scattering observed cataracts. The provides a thorough assessment various strategies aimed at preventing managing cataracts, such as dietary antioxidants (i.e., vitamins C E, lutein, zeaxanthin), well pharmacological agents with antioxidative properties. Furthermore, explores innovative therapeutic approaches, including gene therapy nanotechnology-based delivery systems, designed bolster defenses tissues. Concluding critical analysis current research, offers evidence-based recommendations for optimizing therapies. literature on use prevent is sparse. There lack conclusions; further clinical studies are needed endorse patients cataractogenesis. However, personalized treatment plans considering individual patient factors disease stages can be applied. serves valuable resource, providing insights into alleviate burden
Язык: Английский
Процитировано
7
Molecular Biotechnology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
European Journal of Ophthalmology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 21, 2025
Introduction Myopia is a refractive error where distant objects are not clearly seen and appear blurred. Goal of this study was to evaluate long-term effectiveness Repeated Low-Level Red Light (RLRL) therapy for children with myopia, which primarily focused on Axial length (AL) Spherical Equivalent Refraction (SER) as primary endpoints. Methods The research compared outcomes between RLRL treatment Single Vision Spectacles (SVS) childhood myopia management. We performed systematic literature search in the PubMed, Embase Cochrane databases using “Myopia” “ “. Mean differences (MD) were estimated effects therapies measured. Publication bias heterogeneity analysis carried out by Inverted Precision Effect Test-Precision Estimate Standard Error (PET-PEESE) (and subsequent Search Sequential Analysis) Tau test. Bayesian meta-analysis Jaffrey Amazing Statistical Package (JASP). Results This comprised 1,714 participants: 824 890 SVS group. Pooled effect size AL reduction 0.953 ± 0.294, (95% credible interval (CI) 0.775 0.980). SER 1.521 0.662 CI 0.102 2.736). PET-PEESE revealed no significant publication ( p-value 0.407). Random models employed presence (3.9 5.7 AL; SER), alongside degree variation (0.828 & 1.665) (τ), estimates between-study variance. Conclusion Long-term observations indicate that significantly influences management, leading considerable reductions both SER. Additional essential investigate potential rebound effects.
Язык: Английский
Процитировано
0
Trends in Food Science & Technology, Год журнала: 2025, Номер 159, С. 104944 - 104944
Опубликована: Фев. 26, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2174 - 2174
Опубликована: Фев. 28, 2025
Metabolic syndrome (MetS)-a cluster of conditions including obesity, hypertension, dyslipidemia, and insulin resistance-is increasingly recognized as a key risk factor for the development various eye diseases. The metabolic dysfunctions associated with this contribute to vascular neurodegenerative damage within eye, influencing disease onset progression. Understanding these links highlights importance early diagnosis management prevent vision loss improve ocular health outcomes. This review explores intricate interplay between syndrome, chronic low-grade inflammation, diseases such diabetic retinopathy, age-related macular degeneration, glaucoma, dry syndrome. It how inflammatory mediators, oxidative damage, dysregulation converge compromise structures, retina, optic nerve, surface. We discuss molecular cellular mechanisms underpinning associations examine evidence from clinical experimental studies. Given rising global prevalence addressing connection is crucial improving overall patient outcomes quality life. Future research should focus on delineating precise linking well exploring targeted interventions that address both health.
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2024, Номер 12(7), С. 1579 - 1579
Опубликована: Июль 16, 2024
This review article delves into the intricate roles of reactive oxygen species (ROS) in pathogenesis age-related macular degeneration (AMD). It presents a detailed analysis oxidative stress mechanisms that contribute to development and progression these diseases. The systematically explores dual nature ROS ocular physiology pathology, underscoring their essential cellular signaling detrimental effects when excess. In context AMD, focus is on impairment retinal pigment epithelium Bruch's membrane, culminating deterioration health. Central this evaluation various antioxidant strategies prevention management AMD. encompasses wide spectrum antioxidants, ranging from dietary nutrients like vitamins C E, lutein, zeaxanthin pharmacological agents with antioxidative properties. also addresses novel therapeutic approaches, including gene therapy nanotechnology-based delivery systems, aiming enhance defense tissues. concludes by synthesizing current research findings, clinical trial data, meta-analyses provide evidence-based recommendations. underscores need for further optimize therapies, considering individual patient factors disease stages. comprehensive thus serves as valuable resource clinicians, researchers, healthcare professionals ophthalmology, offering insights potential antioxidants mitigating burden
Язык: Английский
Процитировано
1
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 23, 2024
Abstract Posterior uveitis is a leading cause of vision impairment and blindness globally due to its detrimental effects on the choroid retina. The condition worsened by oxidative stress, which heightens inflammation perpetuates cycle damage that current treatments only temporarily relieve. To address this, novel treatment involving in situ crystallization ultrasmall cerium oxide nanoparticles (≈3 nm) mesenchymal stem cell (MSC) extracellular vesicles (EVs) for management primed mycobacterial (PMU) developed. This nanohybrid leverages individual synergistic components comprehensive therapeutic approach. act as nanozyme reduce scavenge excessive reactive oxygen species (ROS), while MSC EVs, with their biocompatibility, modulate inflammatory infiltration alleviate tissue damage. system offers promising new strategy ocular diseases characterized stress inflammation.
Язык: Английский
Процитировано
1
Experimental Eye Research, Год журнала: 2024, Номер 249, С. 110124 - 110124
Опубликована: Окт. 11, 2024
Язык: Английский
Процитировано
0
Investigative Ophthalmology & Visual Science, Год журнала: 2024, Номер 65(13), С. 11 - 11
Опубликована: Ноя. 6, 2024
Purpose: This study aims to investigate the effect of quercetin (QUE) on scleral remodeling by inhibiting PERK-EIF2α signaling pathway and evaluate its potential role in slowing myopia. Methods: Lens-induced myopia (LIM) guinea pigs were obtained treated with QUE. After 4 6 weeks treatments, ocular biological measurements conducted. Hematoxylin eosin (H&E) staining was used observe changes morphology thickness, Masson examine collagen fiber arrangement. Quantitative PCR (qPCR) Western bolt utilized detect mRNA protein expression PERK, EIF2α, MMP-2, TIMP-2, I tissues. Calcium ion flow each group measured using noninvasive micro-test technology, reactive oxygen species levels detected cytometry. Results: Compared LIM group, showed that refractive errors axial length eyes significantly reduced + QUE (P < 0.01). H&E sclera thickened, dense, gap reduced. In MMP-2 decreased, whereas TIMP-2 increased. release (ROS) decreased. Conclusions: Quercetin ameliorates myopic pathway, thereby alleviating progression These findings provide new experimental evidence for application prevention treatment.
Язык: Английский
Процитировано
0
Tissue and Cell, Год журнала: 2024, Номер 93, С. 102687 - 102687
Опубликована: Дек. 18, 2024
Язык: Английский
Процитировано
0