Natural Products and Health Care Functions of Inonotus obliquus
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(4), С. 269 - 269
Опубликована: Апрель 10, 2025
With
the
increasing
attention
of
modern
medicine
to
natural
medicinal
agents,
Inonotus
obliquus
(chaga),
a
macrofungus
with
remarkable
value,
has
gradually
garnered
widespread
academic
interest.
This
paper
reviews
primary
bioactive
components
I.
in
recent
years,
including
polysaccharides,
phenolic
compounds,
and
triterpenoids,
which
exhibit
diverse
pharmacological
effects
such
as
antioxidant,
anti-inflammatory,
immunomodulatory,
antitumor
activities.
It
further
discusses
how
these
enhance
human
health
disease
resistance
through
distinct
biological
mechanisms,
activation
antioxidant
systems,
regulation
immune
responses,
modulation
apoptosis
pathways.
Additionally,
article
explores
biosynthetic
pathways
metabolites
their
relevance.
Finally,
we
summarize
potential
resource
envisage
its
future
applications
clinical
drug
development.
review
aims
provide
novel
perspectives
for
cultivation,
utilization,
industrial-scale
exploitation
obliquus.
Язык: Английский
Research Progress and Application of Miniature CRISPR-Cas12 System in Gene Editing
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12686 - 12686
Опубликована: Ноя. 26, 2024
CRISPR-Cas
system,
a
natural
acquired
immune
system
in
prokaryotes
that
defends
against
exogenous
DNA
invasion
because
of
its
simple
structure
and
easy
operation,
has
been
widely
used
many
research
fields
such
as
synthetic
biology,
crop
genetics
breeding,
precision
medicine,
so
on.
The
miniature
CRISPR-Cas12
an
emerging
genome
editing
tool
recent
years.
Compared
to
the
commonly
CRISPR-Cas9
CRISPR-Cas12a,
unique
advantages,
rich
PAM
sites,
higher
specificity,
smaller
volume,
cytotoxicity.
However,
application
Cas12
proteins
methods
improve
efficiency
have
not
systematically
summarized.
In
this
review,
we
introduce
classification
summarize
structural
characteristics
type
V
cleavage
mechanism
five
proteins.
gene
animals,
plants,
microorganisms
is
summarized,
strategies
are
discussed,
aiming
provide
reference
for
further
understanding
functional
engineering
modification
system.
Язык: Английский