Advances in Understanding the Pathogenesis of Sensorineural Hearing Loss: Treatment Strategies and Implications for Auditory Protection DOI Creative Commons
Lin Yan,

Yuhua Zhang,

Yongjie Wei

и другие.

Опубликована: Апрель 20, 2025

ABSTRACT Sensorineural hearing loss (SNHL) is a prevalent multifactorial condition affecting over 1.5 billion people worldwide. Its etiology includes genetic mutations, environmental factors, and age‐related degeneration, leading to irreversible damage the cochlear hair cells auditory neurons. Although conventional interventions, such as aids implants, provide partial relief, they do not restore natural function. Recent advances in understanding of molecular mechanisms underlying SNHL, including oxidative stress, autophagy, apoptosis, ferroptosis, pyroptosis, have provided novel insights into potential therapeutic targets. Emerging treatment strategies include gene therapy, which aims correct defects through replacement editing; exosome‐based facilitates cellular repair protection; stem cell promotes neurons regeneration; nanomedicine, enables targeted drug delivery protection. Despite these promising developments, challenges remain translating therapies from preclinical research clinical applications, owing safety, efficiency, long‐term efficacy concerns. This review summarizes latest progress SNHL research, highlights key pathophysiological mechanisms, explores strategies. Understanding essential develop effective interventions prevent, potentially reverse ultimately improving quality life affected individuals.

Язык: Английский

Advances in Understanding the Pathogenesis of Sensorineural Hearing Loss: Treatment Strategies and Implications for Auditory Protection DOI Creative Commons
Lin Yan,

Yuhua Zhang,

Yongjie Wei

и другие.

Опубликована: Апрель 20, 2025

ABSTRACT Sensorineural hearing loss (SNHL) is a prevalent multifactorial condition affecting over 1.5 billion people worldwide. Its etiology includes genetic mutations, environmental factors, and age‐related degeneration, leading to irreversible damage the cochlear hair cells auditory neurons. Although conventional interventions, such as aids implants, provide partial relief, they do not restore natural function. Recent advances in understanding of molecular mechanisms underlying SNHL, including oxidative stress, autophagy, apoptosis, ferroptosis, pyroptosis, have provided novel insights into potential therapeutic targets. Emerging treatment strategies include gene therapy, which aims correct defects through replacement editing; exosome‐based facilitates cellular repair protection; stem cell promotes neurons regeneration; nanomedicine, enables targeted drug delivery protection. Despite these promising developments, challenges remain translating therapies from preclinical research clinical applications, owing safety, efficiency, long‐term efficacy concerns. This review summarizes latest progress SNHL research, highlights key pathophysiological mechanisms, explores strategies. Understanding essential develop effective interventions prevent, potentially reverse ultimately improving quality life affected individuals.

Язык: Английский

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